PMC:7105881 / 40080-40670 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1216","span":{"begin":479,"end":484},"obj":"Gene"},{"id":"1217","span":{"begin":244,"end":252},"obj":"Species"},{"id":"1218","span":{"begin":383,"end":391},"obj":"Species"},{"id":"1219","span":{"begin":428,"end":432},"obj":"Chemical"},{"id":"1220","span":{"begin":438,"end":451},"obj":"Chemical"},{"id":"1221","span":{"begin":551,"end":555},"obj":"Chemical"}],"attributes":[{"id":"A1216","pred":"tao:has_database_id","subj":"1216","obj":"Gene:668478"},{"id":"A1217","pred":"tao:has_database_id","subj":"1217","obj":"Tax:694009"},{"id":"A1218","pred":"tao:has_database_id","subj":"1218","obj":"Tax:694009"},{"id":"A1219","pred":"tao:has_database_id","subj":"1219","obj":"MESH:C041524"},{"id":"A1221","pred":"tao:has_database_id","subj":"1221","obj":"MESH:C041524"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T241","span":{"begin":262,"end":270},"obj":"Body_part"},{"id":"T242","span":{"begin":485,"end":493},"obj":"Body_part"}],"attributes":[{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T227","span":{"begin":60,"end":64},"obj":"Disease"},{"id":"T228","span":{"begin":244,"end":252},"obj":"Disease"},{"id":"T229","span":{"begin":383,"end":391},"obj":"Disease"}],"attributes":[{"id":"A227","pred":"mondo_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A228","pred":"mondo_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A229","pred":"mondo_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T520","span":{"begin":152,"end":154},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T521","span":{"begin":152,"end":154},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T522","span":{"begin":259,"end":261},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T523","span":{"begin":353,"end":355},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T524","span":{"begin":353,"end":355},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T525","span":{"begin":381,"end":382},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T526","span":{"begin":461,"end":462},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T527","span":{"begin":498,"end":514},"obj":"http://purl.obolibrary.org/obo/PR_000000017"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T252","span":{"begin":114,"end":123},"obj":"Chemical"},{"id":"T253","span":{"begin":152,"end":154},"obj":"Chemical"},{"id":"T254","span":{"begin":262,"end":270},"obj":"Chemical"},{"id":"T255","span":{"begin":353,"end":355},"obj":"Chemical"},{"id":"T256","span":{"begin":442,"end":451},"obj":"Chemical"},{"id":"T257","span":{"begin":498,"end":508},"obj":"Chemical"},{"id":"T258","span":{"begin":509,"end":514},"obj":"Chemical"}],"attributes":[{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T76","span":{"begin":523,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"2_test","denotations":[{"id":"32265848-16919855-36511169","span":{"begin":146,"end":150},"obj":"16919855"},{"id":"32265848-23573979-36511170","span":{"begin":163,"end":167},"obj":"23573979"},{"id":"32265848-23573979-36511171","span":{"begin":364,"end":368},"obj":"23573979"},{"id":"32265848-16919855-36511172","span":{"begin":584,"end":588},"obj":"16919855"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T229","span":{"begin":0,"end":169},"obj":"Sentence"},{"id":"T230","span":{"begin":170,"end":370},"obj":"Sentence"},{"id":"T231","span":{"begin":371,"end":590},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T717","span":{"begin":42,"end":56},"obj":"BV_15"},{"id":"T718","span":{"begin":60,"end":64},"obj":"SP_10"},{"id":"T719","span":{"begin":114,"end":123},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T720","span":{"begin":195,"end":205},"obj":"GO:0042571"},{"id":"T721","span":{"begin":244,"end":252},"obj":"SP_10"},{"id":"T722","span":{"begin":383,"end":391},"obj":"SP_10"},{"id":"T723","span":{"begin":412,"end":422},"obj":"MOP:0000779"},{"id":"T724","span":{"begin":442,"end":451},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T725","span":{"begin":485,"end":493},"obj":"GO:0042571"},{"id":"T726","span":{"begin":498,"end":514},"obj":"PR:000000017"},{"id":"T727","span":{"begin":516,"end":521},"obj":"PR:000000017"},{"id":"T57205","span":{"begin":42,"end":56},"obj":"BV_15"},{"id":"T14723","span":{"begin":60,"end":64},"obj":"SP_10"},{"id":"T90462","span":{"begin":114,"end":123},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T1050","span":{"begin":195,"end":205},"obj":"GO:0042571"},{"id":"T33718","span":{"begin":244,"end":252},"obj":"SP_10"},{"id":"T51268","span":{"begin":383,"end":391},"obj":"SP_10"},{"id":"T8909","span":{"begin":412,"end":422},"obj":"MOP:0000779"},{"id":"T83455","span":{"begin":442,"end":451},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T17832","span":{"begin":485,"end":493},"obj":"GO:0042571"},{"id":"T54895","span":{"begin":498,"end":514},"obj":"PR:000000017"},{"id":"T18175","span":{"begin":516,"end":521},"obj":"PR:000000017"}],"text":"Other factors that potentially affect the immunogenicity of SARS subunit vaccines include immunization routes and adjuvants (Zakhartchouk et al., 2007; Li et al., 2013). Significantly high-titer antibodies were induced by monomeric or trimeric SARS-CoV S and S1 proteins through the intramuscular (I.M.) route compared to the subcutaneous (S.C.) route (Li et al., 2013). Moreover, a SARS-CoV RBD subunit vaccine conjugated with Alum plus CpG adjuvants elicited a higher level of IgG2a antibody and interferon gamma (IFN-γ) secretion than the RBD with Alum alone (Zakhartchouk et al., 2007)."}