PMC:7105881 / 39590-39875 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1197","span":{"begin":136,"end":140},"obj":"Gene"},{"id":"1203","span":{"begin":49,"end":57},"obj":"Species"},{"id":"1209","span":{"begin":28,"end":33},"obj":"Mutation"}],"attributes":[{"id":"A1197","pred":"tao:has_database_id","subj":"1197","obj":"Gene:59272"},{"id":"A1203","pred":"tao:has_database_id","subj":"1203","obj":"Tax:694009"},{"id":"A1209","pred":"tao:has_standard_notation","subj":"1209","obj":"p.R441A"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p63110s15","span":{"begin":58,"end":67},"obj":"NegReg"},{"id":"p63110s18","span":{"begin":78,"end":99},"obj":"MPA"},{"id":"p63110s21","span":{"begin":104,"end":140},"obj":"MPA"},{"id":"p63110s29","span":{"begin":147,"end":157},"obj":"NegReg"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T225","span":{"begin":49,"end":57},"obj":"Disease"}],"attributes":[{"id":"A225","pred":"mondo_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T516","span":{"begin":9,"end":10},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T517","span":{"begin":258,"end":265},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T227","span":{"begin":0,"end":285},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T708","span":{"begin":49,"end":57},"obj":"SP_10"},{"id":"T709","span":{"begin":91,"end":99},"obj":"BV_9"},{"id":"T710","span":{"begin":121,"end":126},"obj":"NCBITaxon:10239"},{"id":"T711","span":{"begin":136,"end":140},"obj":"G_3;PG_10;PR:000003622"},{"id":"T712","span":{"begin":172,"end":186},"obj":"BV_15"},{"id":"T713","span":{"begin":234,"end":244},"obj":"GO:0042571"},{"id":"T714","span":{"begin":258,"end":265},"obj":"NCBITaxon:33208"},{"id":"T88864","span":{"begin":49,"end":57},"obj":"SP_10"},{"id":"T91081","span":{"begin":91,"end":99},"obj":"BV_9"},{"id":"T20227","span":{"begin":121,"end":126},"obj":"NCBITaxon:10239"},{"id":"T95863","span":{"begin":136,"end":140},"obj":"G_3;PG_10;PR:000003622"},{"id":"T94059","span":{"begin":172,"end":186},"obj":"BV_15"},{"id":"T73841","span":{"begin":234,"end":244},"obj":"GO:0042571"},{"id":"T65342","span":{"begin":258,"end":265},"obj":"NCBITaxon:33208"}],"text":"Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b)."}