PMC:7105881 / 39579-40083 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7105881","sourcedb":"PMC","sourceid":"7105881","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7105881","text":"formation. Notably, a single mutation (R441A) in the RBD of SARS-CoV disrupted its major neutralizing epitopes and affinity to bind viral receptor ACE2, thus abolishing the vaccine’s immunogenicity, and hence, its ability to induce neutralizing antibodies in immunized animals (He et al., 2006b). Additionally, deletion of a particular amino acid by changing a glycosylation site in the SARS-CoV RBD (RBD219-N1) also resulted in the alteration of subunit vaccine’s immunogenicity (Chen et al., 2014).\nOth","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1197","span":{"begin":147,"end":151},"obj":"Gene"},{"id":"1203","span":{"begin":60,"end":68},"obj":"Species"},{"id":"1204","span":{"begin":387,"end":395},"obj":"Species"},{"id":"1209","span":{"begin":39,"end":44},"obj":"Mutation"}],"attributes":[{"id":"A1197","pred":"tao:has_database_id","subj":"1197","obj":"Gene:59272"},{"id":"A1203","pred":"tao:has_database_id","subj":"1203","obj":"Tax:694009"},{"id":"A1204","pred":"tao:has_database_id","subj":"1204","obj":"Tax:694009"},{"id":"A1209","pred":"tao:has_standard_notation","subj":"1209","obj":"p.R441A"},{"subj":"1197","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1209","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T240","span":{"begin":336,"end":346},"obj":"Body_part"}],"attributes":[{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma82739"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid_AGAC","denotations":[{"id":"p63110s15","span":{"begin":69,"end":78},"obj":"NegReg"},{"id":"p63110s18","span":{"begin":89,"end":110},"obj":"MPA"},{"id":"p63110s21","span":{"begin":115,"end":151},"obj":"MPA"},{"id":"p63110s29","span":{"begin":158,"end":168},"obj":"NegReg"},{"id":"p63112s34","span":{"begin":465,"end":479},"obj":"MPA"}],"attributes":[{"subj":"p63110s15","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p63110s18","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p63110s21","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p63110s29","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p63112s34","pred":"source","obj":"LitCovid_AGAC"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T225","span":{"begin":60,"end":68},"obj":"Disease"},{"id":"T226","span":{"begin":387,"end":395},"obj":"Disease"}],"attributes":[{"id":"A225","pred":"mondo_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A226","pred":"mondo_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T516","span":{"begin":20,"end":21},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T517","span":{"begin":269,"end":276},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T518","span":{"begin":323,"end":324},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T519","span":{"begin":359,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T516","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T517","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T249","span":{"begin":336,"end":346},"obj":"Chemical"},{"id":"T250","span":{"begin":336,"end":341},"obj":"Chemical"},{"id":"T251","span":{"begin":342,"end":346},"obj":"Chemical"}],"attributes":[{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T75","span":{"begin":361,"end":374},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"attributes":[{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"2_test","denotations":[{"id":"32265848-24355931-36511168","span":{"begin":494,"end":498},"obj":"24355931"}],"attributes":[{"subj":"32265848-24355931-36511168","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T227","span":{"begin":11,"end":296},"obj":"Sentence"},{"id":"T228","span":{"begin":297,"end":500},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T227","pred":"source","obj":"LitCovid-sentences"},{"subj":"T228","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T708","span":{"begin":60,"end":68},"obj":"SP_10"},{"id":"T709","span":{"begin":102,"end":110},"obj":"BV_9"},{"id":"T710","span":{"begin":132,"end":137},"obj":"NCBITaxon:10239"},{"id":"T711","span":{"begin":147,"end":151},"obj":"G_3;PG_10;PR:000003622"},{"id":"T712","span":{"begin":183,"end":197},"obj":"BV_15"},{"id":"T713","span":{"begin":245,"end":255},"obj":"GO:0042571"},{"id":"T714","span":{"begin":269,"end":276},"obj":"NCBITaxon:33208"},{"id":"T715","span":{"begin":387,"end":395},"obj":"SP_10"},{"id":"T716","span":{"begin":465,"end":479},"obj":"BV_15"},{"id":"T88864","span":{"begin":60,"end":68},"obj":"SP_10"},{"id":"T91081","span":{"begin":102,"end":110},"obj":"BV_9"},{"id":"T20227","span":{"begin":132,"end":137},"obj":"NCBITaxon:10239"},{"id":"T95863","span":{"begin":147,"end":151},"obj":"G_3;PG_10;PR:000003622"},{"id":"T94059","span":{"begin":183,"end":197},"obj":"BV_15"},{"id":"T73841","span":{"begin":245,"end":255},"obj":"GO:0042571"},{"id":"T65342","span":{"begin":269,"end":276},"obj":"NCBITaxon:33208"},{"id":"T44219","span":{"begin":387,"end":395},"obj":"SP_10"},{"id":"T65405","span":{"begin":465,"end":479},"obj":"BV_15"}],"attributes":[{"subj":"T708","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T709","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T710","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T711","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T712","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T713","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T714","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T715","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T716","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88864","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T91081","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20227","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95863","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T94059","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73841","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65342","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T44219","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65405","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#cc93ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecb2"},{"id":"LitCovid_AGAC","color":"#ec9893"},{"id":"LitCovid-PD-MONDO","color":"#93a7ec"},{"id":"LitCovid-PD-CLO","color":"#c1ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93db"},{"id":"LitCovid-PD-GO-BP","color":"#93ece2"},{"id":"2_test","color":"#ecc893"},{"id":"LitCovid-sentences","color":"#ae93ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ec94"}]}]}}