PMC:7105881 / 39221-39589 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1199","span":{"begin":14,"end":22},"obj":"Species"},{"id":"1200","span":{"begin":59,"end":68},"obj":"Species"},{"id":"1201","span":{"begin":191,"end":198},"obj":"Species"},{"id":"1202","span":{"begin":262,"end":271},"obj":"Species"},{"id":"1205","span":{"begin":2,"end":13},"obj":"Species"},{"id":"1208","span":{"begin":32,"end":36},"obj":"CellLine"}],"attributes":[{"id":"A1199","pred":"tao:has_database_id","subj":"1199","obj":"Tax:694009"},{"id":"A1200","pred":"tao:has_database_id","subj":"1200","obj":"Tax:9606"},{"id":"A1201","pred":"tao:has_database_id","subj":"1201","obj":"Tax:562"},{"id":"A1202","pred":"tao:has_database_id","subj":"1202","obj":"Tax:9606"},{"id":"A1205","pred":"tao:has_database_id","subj":"1205","obj":"Tax:575864"},{"id":"A1208","pred":"tao:has_database_id","subj":"1208","obj":"CVCL:0063"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T235","span":{"begin":38,"end":45},"obj":"Body_part"},{"id":"T236","span":{"begin":69,"end":73},"obj":"Body_part"},{"id":"T237","span":{"begin":122,"end":130},"obj":"Body_part"},{"id":"T238","span":{"begin":171,"end":176},"obj":"Body_part"},{"id":"T239","span":{"begin":272,"end":277},"obj":"Body_part"}],"attributes":[{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p63109s23","span":{"begin":109,"end":139},"obj":"MPA"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T224","span":{"begin":14,"end":22},"obj":"Disease"}],"attributes":[{"id":"A224","pred":"mondo_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T506","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T507","span":{"begin":32,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T508","span":{"begin":32,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T509","span":{"begin":32,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T510","span":{"begin":69,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T511","span":{"begin":171,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T512","span":{"begin":182,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0008989"},{"id":"T513","span":{"begin":204,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0002878"},{"id":"T514","span":{"begin":272,"end":277},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T515","span":{"begin":278,"end":281},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T248","span":{"begin":38,"end":45},"obj":"Chemical"}],"attributes":[{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T226","span":{"begin":0,"end":368},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T698","span":{"begin":14,"end":22},"obj":"SP_10"},{"id":"T699","span":{"begin":32,"end":36},"obj":"CL_4"},{"id":"T700","span":{"begin":46,"end":55},"obj":"GO:0010467"},{"id":"T701","span":{"begin":59,"end":68},"obj":"NCBITaxon:40674"},{"id":"T702","span":{"begin":122,"end":130},"obj":"GO:0042571;BV_1"},{"id":"T703","span":{"begin":131,"end":139},"obj":"BV_1"},{"id":"T704","span":{"begin":151,"end":160},"obj":"GO:0010467"},{"id":"T705","span":{"begin":164,"end":170},"obj":"NCBITaxon:6960"},{"id":"T706","span":{"begin":191,"end":198},"obj":"NCBITaxon:562"},{"id":"T707","span":{"begin":262,"end":271},"obj":"NCBITaxon:40674"},{"id":"T69084","span":{"begin":14,"end":22},"obj":"SP_10"},{"id":"T37230","span":{"begin":32,"end":36},"obj":"CL_4"},{"id":"T94323","span":{"begin":46,"end":55},"obj":"GO:0010467"},{"id":"T46234","span":{"begin":59,"end":68},"obj":"NCBITaxon:40674"},{"id":"T3119","span":{"begin":122,"end":130},"obj":"GO:0042571;BV_1"},{"id":"T49376","span":{"begin":131,"end":139},"obj":"BV_1"},{"id":"T69021","span":{"begin":151,"end":160},"obj":"GO:0010467"},{"id":"T5788","span":{"begin":164,"end":170},"obj":"NCBITaxon:6960"},{"id":"T24651","span":{"begin":191,"end":198},"obj":"NCBITaxon:562"},{"id":"T13303","span":{"begin":262,"end":271},"obj":"NCBITaxon:40674"}],"text":"A recombinant SARS-CoV RBD (RBD-293T) protein expressed in mammalian cell system was able to induce stronger neutralizing antibody response than those expressed in insect cells (RBD-Sf9) and E. coli (RBD-Ec) (Du et al., 2009b), suggesting that RBD purified from mammalian cells has preference for further development due to its ability to maintain native conformation."}