PMC:7105881 / 36525-36969 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1150","span":{"begin":142,"end":146},"obj":"Gene"},{"id":"1151","span":{"begin":151,"end":156},"obj":"Gene"},{"id":"1152","span":{"begin":376,"end":381},"obj":"Gene"},{"id":"1154","span":{"begin":45,"end":53},"obj":"Species"},{"id":"1155","span":{"begin":200,"end":204},"obj":"Species"},{"id":"1156","span":{"begin":222,"end":229},"obj":"Species"},{"id":"1157","span":{"begin":400,"end":404},"obj":"Species"},{"id":"1162","span":{"begin":266,"end":282},"obj":"Chemical"}],"attributes":[{"id":"A1150","pred":"tao:has_database_id","subj":"1150","obj":"Gene:16017"},{"id":"A1151","pred":"tao:has_database_id","subj":"1151","obj":"Gene:668478"},{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"Gene:668478"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"Tax:694009"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"Tax:10090"},{"id":"A1156","pred":"tao:has_database_id","subj":"1156","obj":"Tax:562"},{"id":"A1157","pred":"tao:has_database_id","subj":"1157","obj":"Tax:10090"},{"id":"A1162","pred":"tao:has_database_id","subj":"1162","obj":"MESH:C477385"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T209","span":{"begin":56,"end":63},"obj":"Body_part"},{"id":"T210","span":{"begin":116,"end":119},"obj":"Body_part"},{"id":"T211","span":{"begin":242,"end":249},"obj":"Body_part"},{"id":"T212","span":{"begin":287,"end":295},"obj":"Body_part"},{"id":"T213","span":{"begin":306,"end":313},"obj":"Body_part"},{"id":"T214","span":{"begin":347,"end":350},"obj":"Body_part"}],"attributes":[{"id":"A209","pred":"fma_id","subj":"T209","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A210","pred":"fma_id","subj":"T210","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A211","pred":"fma_id","subj":"T211","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A212","pred":"fma_id","subj":"T212","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma82775"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T204","span":{"begin":45,"end":53},"obj":"Disease"}],"attributes":[{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T477","span":{"begin":27,"end":28},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T478","span":{"begin":369,"end":370},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T217","span":{"begin":56,"end":63},"obj":"Chemical"},{"id":"T218","span":{"begin":89,"end":97},"obj":"Chemical"},{"id":"T219","span":{"begin":242,"end":249},"obj":"Chemical"},{"id":"T220","span":{"begin":287,"end":295},"obj":"Chemical"},{"id":"T221","span":{"begin":296,"end":305},"obj":"Chemical"},{"id":"T225","span":{"begin":306,"end":313},"obj":"Chemical"},{"id":"T226","span":{"begin":320,"end":329},"obj":"Chemical"}],"attributes":[{"id":"A217","pred":"chebi_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A218","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A222","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A223","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A224","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"},{"id":"A225","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_16235"},{"id":"A226","pred":"chebi_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T66","span":{"begin":171,"end":196},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T67","span":{"begin":171,"end":196},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T68","span":{"begin":171,"end":196},"obj":"http://purl.obolibrary.org/obo/GO_0002443"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"2_test","denotations":[{"id":"32265848-16494977-36511156","span":{"begin":418,"end":422},"obj":"16494977"},{"id":"32265848-19523911-36511157","span":{"begin":438,"end":442},"obj":"19523911"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T213","span":{"begin":0,"end":444},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T624","span":{"begin":29,"end":34},"obj":"NCBITaxon:3193"},{"id":"T625","span":{"begin":35,"end":44},"obj":"GO:0010467"},{"id":"T626","span":{"begin":45,"end":53},"obj":"SP_10"},{"id":"T627","span":{"begin":54,"end":63},"obj":"PG_4"},{"id":"T628","span":{"begin":64,"end":74},"obj":"MOP:0000779"},{"id":"T629","span":{"begin":89,"end":97},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T630","span":{"begin":116,"end":130},"obj":"GO:0071743"},{"id":"T631","span":{"begin":171,"end":179},"obj":"GO:0006955"},{"id":"T632","span":{"begin":180,"end":186},"obj":"GO:0006955;UBERON:0002405"},{"id":"T633","span":{"begin":187,"end":196},"obj":"GO:0006955"},{"id":"T634","span":{"begin":200,"end":204},"obj":"NCBITaxon:10088"},{"id":"T635","span":{"begin":222,"end":229},"obj":"NCBITaxon:562"},{"id":"T636","span":{"begin":230,"end":239},"obj":"GO:0010467"},{"id":"T637","span":{"begin":240,"end":249},"obj":"PG_4"},{"id":"T638","span":{"begin":250,"end":260},"obj":"MOP:0000779"},{"id":"T639","span":{"begin":320,"end":329},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T640","span":{"begin":347,"end":361},"obj":"GO:0071743"},{"id":"T641","span":{"begin":371,"end":374},"obj":"PR:000008439"},{"id":"T642","span":{"begin":400,"end":404},"obj":"NCBITaxon:10088"},{"id":"T87341","span":{"begin":29,"end":34},"obj":"NCBITaxon:3193"},{"id":"T13171","span":{"begin":35,"end":44},"obj":"GO:0010467"},{"id":"T69689","span":{"begin":45,"end":53},"obj":"SP_10"},{"id":"T47501","span":{"begin":54,"end":63},"obj":"PG_4"},{"id":"T27582","span":{"begin":64,"end":74},"obj":"MOP:0000779"},{"id":"T40355","span":{"begin":89,"end":97},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T25023","span":{"begin":116,"end":130},"obj":"GO:0071743"},{"id":"T95568","span":{"begin":171,"end":179},"obj":"GO:0006955"},{"id":"T40799","span":{"begin":180,"end":186},"obj":"GO:0006955;UBERON:0002405"},{"id":"T32990","span":{"begin":187,"end":196},"obj":"GO:0006955"},{"id":"T32822","span":{"begin":200,"end":204},"obj":"NCBITaxon:10088"},{"id":"T55834","span":{"begin":222,"end":229},"obj":"NCBITaxon:562"},{"id":"T49090","span":{"begin":230,"end":239},"obj":"GO:0010467"},{"id":"T20679","span":{"begin":240,"end":249},"obj":"PG_4"},{"id":"T37882","span":{"begin":250,"end":260},"obj":"MOP:0000779"},{"id":"T74947","span":{"begin":320,"end":329},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T35300","span":{"begin":347,"end":361},"obj":"GO:0071743"},{"id":"T87273","span":{"begin":371,"end":374},"obj":"PR:000008439"},{"id":"T44979","span":{"begin":400,"end":404},"obj":"NCBITaxon:10088"}],"text":"Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009)."}