PMC:7105881 / 36317-37707
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1133 | 0-8 | Species | denotes | SARS-CoV | Tax:694009 |
| 1150 | 350-354 | Gene | denotes | IgG1 | Gene:16017 |
| 1151 | 359-364 | Gene | denotes | IgG2a | Gene:668478 |
| 1152 | 584-589 | Gene | denotes | IgG2a | Gene:668478 |
| 1153 | 111-119 | Species | denotes | SARS-CoV | Tax:694009 |
| 1154 | 253-261 | Species | denotes | SARS-CoV | Tax:694009 |
| 1155 | 408-412 | Species | denotes | mice | Tax:10090 |
| 1156 | 430-437 | Species | denotes | E. coli | Tax:562 |
| 1157 | 608-612 | Species | denotes | mice | Tax:10090 |
| 1158 | 730-737 | Species | denotes | patient | Tax:9606 |
| 1159 | 964-972 | Species | denotes | patients | Tax:9606 |
| 1160 | 987-992 | Species | denotes | mouse | Tax:10090 |
| 1161 | 1066-1073 | Species | denotes | rabbits | Tax:9986 |
| 1162 | 474-490 | Chemical | denotes | Montanide ISA-51 | MESH:C477385 |
| 1163 | 808-826 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1164 | 1252-1270 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1165 | 1371-1389 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T207 | 52-60 | Body_part | denotes | Proteins | http://purl.org/sig/ont/fma/fma67257 |
| T208 | 99-107 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T209 | 264-271 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T210 | 324-327 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T211 | 450-457 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T212 | 495-503 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
| T213 | 514-521 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
| T214 | 555-558 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T215 | 877-884 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T216 | 1048-1051 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T217 | 1323-1330 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T202 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T203 | 111-119 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T204 | 253-261 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T205 | 725-729 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T206 | 808-826 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T207 | 817-826 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T208 | 959-963 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T209 | 1165-1169 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T210 | 1252-1270 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T211 | 1261-1270 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T212 | 1337-1341 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T213 | 1371-1389 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T214 | 1380-1389 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T476 | 160-167 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T477 | 235-236 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T478 | 577-578 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T479 | 791-799 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T480 | 885-893 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T481 | 895-897 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
| T482 | 895-897 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
| T483 | 987-992 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T216 | 99-107 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T217 | 264-271 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T218 | 297-305 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T219 | 450-457 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T220 | 495-503 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
| T221 | 504-513 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T225 | 514-521 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
| T226 | 528-537 | Chemical | denotes | adjuvants | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T227 | 877-884 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T228 | 885-893 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T229 | 895-897 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
| T233 | 1323-1330 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T66 | 379-404 | http://purl.obolibrary.org/obo/GO_0002456 | denotes | cellular immune responses |
| T67 | 379-404 | http://purl.obolibrary.org/obo/GO_0002449 | denotes | cellular immune responses |
| T68 | 379-404 | http://purl.obolibrary.org/obo/GO_0002443 | denotes | cellular immune responses |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32265848-16494977-36511154 | 181-185 | 16494977 | denotes | 2006 |
| 32265848-19523911-36511155 | 201-205 | 19523911 | denotes | 2009 |
| 32265848-16494977-36511156 | 626-630 | 16494977 | denotes | 2006 |
| 32265848-19523911-36511157 | 646-650 | 19523911 | denotes | 2009 |
| 32265848-15878679-36511158 | 840-844 | 15878679 | denotes | 2005 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T211 | 0-60 | Sentence | denotes | SARS-CoV Subunit Vaccines Based on Non-S Structural Proteins |
| T212 | 61-207 | Sentence | denotes | Subunit vaccines based on the N and M proteins of SARS-CoV have shown immunogenicity in vaccinated animals (Liu et al., 2006; Zheng et al., 2009). |
| T213 | 208-652 | Sentence | denotes | Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009). |
| T214 | 653-846 | Sentence | denotes | Although N-specific antibodies have been detected in convalescent-phase SARS patient and immunized rabbit sera, they have no neutralizing activity against SARS-CoV infection (Qiu et al., 2005). |
| T215 | 847-1093 | Sentence | denotes | In addition, immunodominant M protein peptides (M1-31 and M132-161) identified using convalescent-phase sera of SARS patients and immunized mouse and rabbit sera have immunogenicity to elicit specific IgG antibodies in rabbits (He et al., 2005b). |
| T216 | 1094-1271 | Sentence | denotes | In spite of their immunogenicity, it appears that these N- and M-based SARS subunit vaccines have not been investigated for their protective efficacy against SARS-CoV infection. |
| T217 | 1272-1390 | Sentence | denotes | Thus, it is unclear whether these non-S structural protein-based SARS subunit vaccines can prevent SARS-CoV infection. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T620 | 0-8 | SP_10 | denotes | SARS-CoV |
| T621 | 111-119 | SP_10 | denotes | SARS-CoV |
| T622 | 131-145 | BV_15 | denotes | immunogenicity |
| T623 | 160-167 | NCBITaxon:33208 | denotes | animals |
| T624 | 237-242 | NCBITaxon:3193 | denotes | plant |
| T625 | 243-252 | GO:0010467 | denotes | expressed |
| T626 | 253-261 | SP_10 | denotes | SARS-CoV |
| T627 | 262-271 | PG_4 | denotes | N protein |
| T628 | 272-282 | MOP:0000779 | denotes | conjugated |
| T629 | 297-305 | CHEBI:60809;CHEBI:60809 | denotes | adjuvant |
| T630 | 324-338 | GO:0071743 | denotes | IgG antibodies |
| T631 | 379-387 | GO:0006955 | denotes | cellular |
| T632 | 388-394 | GO:0006955;UBERON:0002405 | denotes | immune |
| T633 | 395-404 | GO:0006955 | denotes | responses |
| T634 | 408-412 | NCBITaxon:10088 | denotes | mice |
| T635 | 430-437 | NCBITaxon:562 | denotes | E. coli |
| T636 | 438-447 | GO:0010467 | denotes | expressed |
| T637 | 448-457 | PG_4 | denotes | N protein |
| T638 | 458-468 | MOP:0000779 | denotes | conjugated |
| T639 | 528-537 | CHEBI:60809;CHEBI:60809 | denotes | adjuvants |
| T640 | 555-569 | GO:0071743 | denotes | IgG antibodies |
| T641 | 579-582 | PR:000008439 | denotes | Th1 |
| T642 | 608-612 | NCBITaxon:10088 | denotes | mice |
| T643 | 673-683 | GO:0042571 | denotes | antibodies |
| T644 | 725-729 | SP_10 | denotes | SARS |
| T645 | 752-758 | NCBITaxon:9986 | denotes | rabbit |
| T646 | 759-763 | UBERON:0001977 | denotes | sera |
| T647 | 808-816 | SP_10 | denotes | SARS-CoV |
| T648 | 875-884 | PG_3 | denotes | M protein |
| T649 | 951-955 | UBERON:0001977 | denotes | sera |
| T650 | 959-963 | SP_10 | denotes | SARS |
| T651 | 987-992 | NCBITaxon:10088 | denotes | mouse |
| T652 | 997-1003 | NCBITaxon:9986 | denotes | rabbit |
| T653 | 1004-1008 | UBERON:0001977 | denotes | sera |
| T654 | 1014-1028 | BV_15 | denotes | immunogenicity |
| T655 | 1048-1062 | GO:0071743 | denotes | IgG antibodies |
| T656 | 1066-1073 | NCBITaxon:9986 | denotes | rabbits |
| T657 | 1112-1126 | BV_15 | denotes | immunogenicity |
| T658 | 1165-1169 | SP_10 | denotes | SARS |
| T659 | 1252-1260 | SP_10 | denotes | SARS-CoV |
| T660 | 1337-1341 | SP_10 | denotes | SARS |
| T661 | 1371-1379 | SP_10 | denotes | SARS-CoV |
| T44327 | 0-8 | SP_10 | denotes | SARS-CoV |
| T96623 | 111-119 | SP_10 | denotes | SARS-CoV |
| T62281 | 131-145 | BV_15 | denotes | immunogenicity |
| T78939 | 160-167 | NCBITaxon:33208 | denotes | animals |
| T87341 | 237-242 | NCBITaxon:3193 | denotes | plant |
| T13171 | 243-252 | GO:0010467 | denotes | expressed |
| T69689 | 253-261 | SP_10 | denotes | SARS-CoV |
| T47501 | 262-271 | PG_4 | denotes | N protein |
| T27582 | 272-282 | MOP:0000779 | denotes | conjugated |
| T40355 | 297-305 | CHEBI:60809;CHEBI:60809 | denotes | adjuvant |
| T25023 | 324-338 | GO:0071743 | denotes | IgG antibodies |
| T95568 | 379-387 | GO:0006955 | denotes | cellular |
| T40799 | 388-394 | GO:0006955;UBERON:0002405 | denotes | immune |
| T32990 | 395-404 | GO:0006955 | denotes | responses |
| T32822 | 408-412 | NCBITaxon:10088 | denotes | mice |
| T55834 | 430-437 | NCBITaxon:562 | denotes | E. coli |
| T49090 | 438-447 | GO:0010467 | denotes | expressed |
| T20679 | 448-457 | PG_4 | denotes | N protein |
| T37882 | 458-468 | MOP:0000779 | denotes | conjugated |
| T74947 | 528-537 | CHEBI:60809;CHEBI:60809 | denotes | adjuvants |
| T35300 | 555-569 | GO:0071743 | denotes | IgG antibodies |
| T87273 | 579-582 | PR:000008439 | denotes | Th1 |
| T44979 | 608-612 | NCBITaxon:10088 | denotes | mice |
| T23242 | 673-683 | GO:0042571 | denotes | antibodies |
| T56583 | 725-729 | SP_10 | denotes | SARS |
| T41465 | 752-758 | NCBITaxon:9986 | denotes | rabbit |
| T90816 | 759-763 | UBERON:0001977 | denotes | sera |
| T77614 | 808-816 | SP_10 | denotes | SARS-CoV |
| T24302 | 875-884 | PG_3 | denotes | M protein |
| T54427 | 951-955 | UBERON:0001977 | denotes | sera |
| T52746 | 959-963 | SP_10 | denotes | SARS |
| T53248 | 987-992 | NCBITaxon:10088 | denotes | mouse |
| T10362 | 997-1003 | NCBITaxon:9986 | denotes | rabbit |
| T17284 | 1004-1008 | UBERON:0001977 | denotes | sera |
| T40413 | 1014-1028 | BV_15 | denotes | immunogenicity |
| T48598 | 1048-1062 | GO:0071743 | denotes | IgG antibodies |
| T75144 | 1066-1073 | NCBITaxon:9986 | denotes | rabbits |
| T26328 | 1112-1126 | BV_15 | denotes | immunogenicity |
| T12143 | 1165-1169 | SP_10 | denotes | SARS |
| T46173 | 1252-1260 | SP_10 | denotes | SARS-CoV |
| T70327 | 1337-1341 | SP_10 | denotes | SARS |
| T14585 | 1371-1379 | SP_10 | denotes | SARS-CoV |