PMC:7105881 / 34088-34504 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1093","span":{"begin":95,"end":110},"obj":"Species"},{"id":"1094","span":{"begin":284,"end":292},"obj":"Species"},{"id":"1095","span":{"begin":304,"end":308},"obj":"Species"},{"id":"1102","span":{"begin":13,"end":24},"obj":"Species"},{"id":"1104","span":{"begin":215,"end":223},"obj":"Species"},{"id":"1106","span":{"begin":118,"end":121},"obj":"CellLine"}],"attributes":[{"id":"A1093","pred":"tao:has_database_id","subj":"1093","obj":"Tax:10029"},{"id":"A1094","pred":"tao:has_database_id","subj":"1094","obj":"Tax:694009"},{"id":"A1095","pred":"tao:has_database_id","subj":"1095","obj":"Tax:10090"},{"id":"A1102","pred":"tao:has_database_id","subj":"1102","obj":"Tax:575864"},{"id":"A1104","pred":"tao:has_database_id","subj":"1104","obj":"Tax:694009"},{"id":"A1106","pred":"tao:has_database_id","subj":"1106","obj":"CVCL:0213"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T191","span":{"begin":111,"end":116},"obj":"Body_part"},{"id":"T192","span":{"begin":123,"end":128},"obj":"Body_part"},{"id":"T193","span":{"begin":334,"end":337},"obj":"Body_part"}],"attributes":[{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma7209"},{"id":"A192","pred":"fma_id","subj":"T192","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A193","pred":"fma_id","subj":"T193","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T185","span":{"begin":215,"end":223},"obj":"Disease"},{"id":"T186","span":{"begin":284,"end":292},"obj":"Disease"}],"attributes":[{"id":"A185","pred":"mondo_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A186","pred":"mondo_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T446","span":{"begin":103,"end":110},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10026"},{"id":"T447","span":{"begin":111,"end":116},"obj":"http://www.ebi.ac.uk/efo/EFO_0000973"},{"id":"T448","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0002421"},{"id":"T449","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0052479"},{"id":"T450","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0052480"},{"id":"T451","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0052483"},{"id":"T452","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0052484"},{"id":"T453","span":{"begin":118,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0052485"},{"id":"T454","span":{"begin":123,"end":128},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"2_test","denotations":[{"id":"32265848-20374001-36511143","span":{"begin":410,"end":414},"obj":"20374001"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T202","span":{"begin":0,"end":416},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T574","span":{"begin":82,"end":91},"obj":"GO:0010467"},{"id":"T575","span":{"begin":111,"end":116},"obj":"UBERON:0000992"},{"id":"T576","span":{"begin":171,"end":181},"obj":"GO:0042571"},{"id":"T577","span":{"begin":215,"end":223},"obj":"SP_10"},{"id":"T578","span":{"begin":237,"end":247},"obj":"GO:0042571"},{"id":"T579","span":{"begin":284,"end":292},"obj":"SP_10"},{"id":"T580","span":{"begin":304,"end":308},"obj":"NCBITaxon:10088"},{"id":"T581","span":{"begin":328,"end":333},"obj":"NCBITaxon:10239"},{"id":"T582","span":{"begin":380,"end":385},"obj":"NCBITaxon:10239"},{"id":"T76668","span":{"begin":82,"end":91},"obj":"GO:0010467"},{"id":"T74849","span":{"begin":111,"end":116},"obj":"UBERON:0000992"},{"id":"T10182","span":{"begin":171,"end":181},"obj":"GO:0042571"},{"id":"T59383","span":{"begin":215,"end":223},"obj":"SP_10"},{"id":"T51937","span":{"begin":237,"end":247},"obj":"GO:0042571"},{"id":"T92066","span":{"begin":284,"end":292},"obj":"SP_10"},{"id":"T63789","span":{"begin":304,"end":308},"obj":"NCBITaxon:10088"},{"id":"T5217","span":{"begin":328,"end":333},"obj":"NCBITaxon:10239"},{"id":"T50236","span":{"begin":380,"end":385},"obj":"NCBITaxon:10239"}],"text":"In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010)."}