PMC:7105343 / 54191-55644 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T350","span":{"begin":261,"end":269},"obj":"Body_part"},{"id":"T351","span":{"begin":300,"end":309},"obj":"Body_part"},{"id":"T352","span":{"begin":310,"end":314},"obj":"Body_part"},{"id":"T353","span":{"begin":310,"end":312},"obj":"Body_part"},{"id":"T354","span":{"begin":316,"end":318},"obj":"Body_part"},{"id":"T355","span":{"begin":325,"end":330},"obj":"Body_part"},{"id":"T356","span":{"begin":325,"end":327},"obj":"Body_part"},{"id":"T357","span":{"begin":418,"end":421},"obj":"Body_part"}],"attributes":[{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A352","pred":"fma_id","subj":"T352","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A353","pred":"fma_id","subj":"T353","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A354","pred":"fma_id","subj":"T354","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A355","pred":"fma_id","subj":"T355","obj":"http://purl.org/sig/ont/fma/fma86579"},{"id":"A356","pred":"fma_id","subj":"T356","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A357","pred":"fma_id","subj":"T357","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T416","span":{"begin":49,"end":53},"obj":"Disease"},{"id":"T417","span":{"begin":124,"end":141},"obj":"Disease"},{"id":"T418","span":{"begin":220,"end":224},"obj":"Disease"},{"id":"T419","span":{"begin":495,"end":514},"obj":"Disease"},{"id":"T420","span":{"begin":628,"end":632},"obj":"Disease"},{"id":"T421","span":{"begin":1118,"end":1153},"obj":"Disease"},{"id":"T422","span":{"begin":1124,"end":1153},"obj":"Disease"},{"id":"T423","span":{"begin":1381,"end":1393},"obj":"Disease"},{"id":"T424","span":{"begin":1428,"end":1446},"obj":"Disease"},{"id":"T426","span":{"begin":1448,"end":1451},"obj":"Disease"}],"attributes":[{"id":"A416","pred":"mondo_id","subj":"T416","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A417","pred":"mondo_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A418","pred":"mondo_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A419","pred":"mondo_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A420","pred":"mondo_id","subj":"T420","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A421","pred":"mondo_id","subj":"T421","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A422","pred":"mondo_id","subj":"T422","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A423","pred":"mondo_id","subj":"T423","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A424","pred":"mondo_id","subj":"T424","obj":"http://purl.obolibrary.org/obo/MONDO_0005380"},{"id":"A425","pred":"mondo_id","subj":"T424","obj":"http://purl.obolibrary.org/obo/MONDO_0018373"},{"id":"A426","pred":"mondo_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/MONDO_0018373"},{"id":"A427","pred":"mondo_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/MONDO_0005380"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T447","span":{"begin":405,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T71865","span":{"begin":0,"end":24},"obj":"Chemical"},{"id":"T21462","span":{"begin":270,"end":280},"obj":"Chemical"},{"id":"T42606","span":{"begin":310,"end":312},"obj":"Chemical"},{"id":"T82866","span":{"begin":316,"end":318},"obj":"Chemical"},{"id":"T13903","span":{"begin":325,"end":327},"obj":"Chemical"},{"id":"T57","span":{"begin":760,"end":775},"obj":"Chemical"},{"id":"T87887","span":{"begin":784,"end":786},"obj":"Chemical"},{"id":"T21113","span":{"begin":787,"end":801},"obj":"Chemical"},{"id":"T25389","span":{"begin":805,"end":823},"obj":"Chemical"},{"id":"T11548","span":{"begin":892,"end":907},"obj":"Chemical"},{"id":"T86768","span":{"begin":1042,"end":1056},"obj":"Chemical"},{"id":"T36508","span":{"begin":1083,"end":1097},"obj":"Chemical"},{"id":"T73649","span":{"begin":1168,"end":1182},"obj":"Chemical"}],"attributes":[{"id":"A4621","pred":"chebi_id","subj":"T71865","obj":"http://purl.obolibrary.org/obo/CHEBI_67079"},{"id":"A86378","pred":"chebi_id","subj":"T21462","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A16941","pred":"chebi_id","subj":"T42606","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A53486","pred":"chebi_id","subj":"T42606","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A33952","pred":"chebi_id","subj":"T82866","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A7305","pred":"chebi_id","subj":"T82866","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A39352","pred":"chebi_id","subj":"T13903","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A5087","pred":"chebi_id","subj":"T13903","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1529","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A86526","pred":"chebi_id","subj":"T87887","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A26214","pred":"chebi_id","subj":"T21113","obj":"http://purl.obolibrary.org/obo/CHEBI_17650"},{"id":"A86301","pred":"chebi_id","subj":"T25389","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"},{"id":"A40933","pred":"chebi_id","subj":"T11548","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A38415","pred":"chebi_id","subj":"T86768","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A32032","pred":"chebi_id","subj":"T36508","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A57976","pred":"chebi_id","subj":"T73649","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T111","span":{"begin":1204,"end":1219},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T112","span":{"begin":1438,"end":1446},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T113","span":{"begin":1438,"end":1446},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T114","span":{"begin":1438,"end":1446},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T115","span":{"begin":1438,"end":1446},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T387","span":{"begin":877,"end":1246},"obj":"Sentence"},{"id":"T388","span":{"begin":1247,"end":1453},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T99","span":{"begin":1124,"end":1144},"obj":"Phenotype"},{"id":"T100","span":{"begin":1381,"end":1393},"obj":"Phenotype"},{"id":"T101","span":{"begin":1395,"end":1423},"obj":"Phenotype"},{"id":"T102","span":{"begin":1428,"end":1446},"obj":"Phenotype"},{"id":"T103","span":{"begin":1448,"end":1451},"obj":"Phenotype"}],"attributes":[{"id":"A99","pred":"hp_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A100","pred":"hp_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A101","pred":"hp_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/HP_0002239"},{"id":"A102","pred":"hp_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/HP_0010885"},{"id":"A103","pred":"hp_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/HP_0010885"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1787","span":{"begin":310,"end":314},"obj":"Gene"},{"id":"1788","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"1789","span":{"begin":325,"end":330},"obj":"Gene"},{"id":"1841","span":{"begin":225,"end":233},"obj":"Species"},{"id":"1842","span":{"begin":738,"end":746},"obj":"Species"},{"id":"1866","span":{"begin":787,"end":801},"obj":"Chemical"},{"id":"1867","span":{"begin":805,"end":823},"obj":"Chemical"},{"id":"1912","span":{"begin":124,"end":141},"obj":"Disease"},{"id":"1913","span":{"begin":495,"end":514},"obj":"Disease"},{"id":"1914","span":{"begin":527,"end":545},"obj":"Disease"},{"id":"1915","span":{"begin":945,"end":970},"obj":"Disease"},{"id":"1917","span":{"begin":1351,"end":1379},"obj":"Disease"},{"id":"1918","span":{"begin":1381,"end":1393},"obj":"Disease"},{"id":"1919","span":{"begin":1395,"end":1423},"obj":"Disease"},{"id":"1920","span":{"begin":1428,"end":1446},"obj":"Disease"}],"attributes":[{"id":"A1787","pred":"tao:has_database_id","subj":"1787","obj":"Gene:3552"},{"id":"A1788","pred":"tao:has_database_id","subj":"1788","obj":"Gene:3569"},{"id":"A1789","pred":"tao:has_database_id","subj":"1789","obj":"Gene:107653060"},{"id":"A1841","pred":"tao:has_database_id","subj":"1841","obj":"Tax:9606"},{"id":"A1842","pred":"tao:has_database_id","subj":"1842","obj":"Tax:9606"},{"id":"A1866","pred":"tao:has_database_id","subj":"1866","obj":"MESH:D006854"},{"id":"A1867","pred":"tao:has_database_id","subj":"1867","obj":"MESH:D008775"},{"id":"A1912","pred":"tao:has_database_id","subj":"1912","obj":"MESH:D008171"},{"id":"A1913","pred":"tao:has_database_id","subj":"1913","obj":"MESH:D012140"},{"id":"A1914","pred":"tao:has_database_id","subj":"1914","obj":"MESH:D012140"},{"id":"A1915","pred":"tao:has_database_id","subj":"1915","obj":"MESH:D009422"},{"id":"A1917","pred":"tao:has_database_id","subj":"1917","obj":"MESH:D007008"},{"id":"A1918","pred":"tao:has_database_id","subj":"1918","obj":"MESH:D006973"},{"id":"A1919","pred":"tao:has_database_id","subj":"1919","obj":"MESH:D006471"},{"id":"A1920","pred":"tao:has_database_id","subj":"1920","obj":"MESH:D010020"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T316","span":{"begin":49,"end":53},"obj":"SP_10"},{"id":"T319","span":{"begin":647,"end":746},"obj":"NCBITaxon:9606"},{"id":"T320","span":{"begin":892,"end":907},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T321","span":{"begin":1232,"end":1237},"obj":"NCBITaxon:10239"},{"id":"T322","span":{"begin":1385,"end":1423},"obj":"UBERON:0001004"}],"text":"Anti-inflammatory agents heavily utilised during SARS outbreak as it was believed that the development and worsening of the pulmonary disease had inflammatory aetiology and pathogenesis.Immunopathological analysis of 20 SARS patients demonstrated increased Th1 cytokine interferon y and inflammatory cytokines IL-1, IL-6 and IL-12 for \u003e 2 weeks following onset of symptoms.Also observed decrease in viral activity and IgG seroconversion during 2nd week of illness despite general progression of respiratory disease- suggesting respiratory damage is secondary to immune-mediated inflammatory response.Corticosteroids used during SARS outbreak for their ability to module variety of involved cytokines.Numerous papers published outcomes of patients administered corticosteroids (mostly IV hydrocortisone or methylprednisolone) in either early low-dose or pulsed-dose strategies. Most concluded corticosteroids appeared to be effective in reducing immunopathological damage (resulting in improved and rapid resolution of symptoms).Opposition to corticosteroid use centred around use of corticosteroid use in treatment of acute respiratory distress syndrome- concern that corticosteroid treatment may weaken immune response and promote viral rebound. Reports also add evidence to theory.Further opposition includes association with adverse events such as hyperglycaemia, hypokalaemia, hypertension, gastrointestinal haemorrhage and avascular necrosis (AVN)."}