PMC:7103735 / 49114-50162 JSONTXT

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{"project":"LitCovid-PD-CLO","denotations":[{"id":"T549","span":{"begin":281,"end":286},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T550","span":{"begin":298,"end":305},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T551","span":{"begin":362,"end":369},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T552","span":{"begin":443,"end":444},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T553","span":{"begin":451,"end":456},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T554","span":{"begin":515,"end":516},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T555","span":{"begin":554,"end":559},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"}],"text":"The interplay between SARS-CoV-2 and host antiviral defence is at the core of viral pathogenesis. It also determines the infection outcome and might explain the existence and risk of asymptomatic carriers. SARS-CoV-2 is very similar to SARS-CoV in many aspects. Lessons from other human pathogenic viruses including SARS-CoV, community-acquired HCoVs, influenza viruses, and HIVs are very enlightening and helpful. However, SARS-CoV-2 is also a novel human pathogen that may interact with host antiviral defence in a unique manner. Basic research in the field of SARS-CoV-2-host interaction holds the key to many important questions in disease control and prevention. Many important questions concerning the identity and mechanisms of interferon antagonists encoded by SARS-CoV-2 will be answered in the months and years to come. Particularly, comparative analyses of SARS-CoV-2 and SARS-CoV will advance the understanding of SARS-CoV-2 pathogenesis. The new knowledge gained will guide the development of vaccines and anti-SARS-CoV-2 therapeutics."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T20362","span":{"begin":42,"end":51},"obj":"Chemical"},{"id":"T10849","span":{"begin":196,"end":204},"obj":"Chemical"},{"id":"T27333","span":{"begin":494,"end":503},"obj":"Chemical"},{"id":"T99681","span":{"begin":735,"end":745},"obj":"Chemical"},{"id":"T69450","span":{"begin":746,"end":757},"obj":"Chemical"}],"attributes":[{"id":"A60308","pred":"chebi_id","subj":"T20362","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A26455","pred":"chebi_id","subj":"T10849","obj":"http://purl.obolibrary.org/obo/CHEBI_78059"},{"id":"A38094","pred":"chebi_id","subj":"T27333","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A53257","pred":"chebi_id","subj":"T99681","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A22352","pred":"chebi_id","subj":"T69450","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"}],"text":"The interplay between SARS-CoV-2 and host antiviral defence is at the core of viral pathogenesis. It also determines the infection outcome and might explain the existence and risk of asymptomatic carriers. SARS-CoV-2 is very similar to SARS-CoV in many aspects. Lessons from other human pathogenic viruses including SARS-CoV, community-acquired HCoVs, influenza viruses, and HIVs are very enlightening and helpful. However, SARS-CoV-2 is also a novel human pathogen that may interact with host antiviral defence in a unique manner. Basic research in the field of SARS-CoV-2-host interaction holds the key to many important questions in disease control and prevention. Many important questions concerning the identity and mechanisms of interferon antagonists encoded by SARS-CoV-2 will be answered in the months and years to come. Particularly, comparative analyses of SARS-CoV-2 and SARS-CoV will advance the understanding of SARS-CoV-2 pathogenesis. The new knowledge gained will guide the development of vaccines and anti-SARS-CoV-2 therapeutics."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T140","span":{"begin":84,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T141","span":{"begin":475,"end":493},"obj":"http://purl.obolibrary.org/obo/GO_0051701"},{"id":"T142","span":{"begin":937,"end":949},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"The interplay between SARS-CoV-2 and host antiviral defence is at the core of viral pathogenesis. It also determines the infection outcome and might explain the existence and risk of asymptomatic carriers. SARS-CoV-2 is very similar to SARS-CoV in many aspects. Lessons from other human pathogenic viruses including SARS-CoV, community-acquired HCoVs, influenza viruses, and HIVs are very enlightening and helpful. However, SARS-CoV-2 is also a novel human pathogen that may interact with host antiviral defence in a unique manner. Basic research in the field of SARS-CoV-2-host interaction holds the key to many important questions in disease control and prevention. Many important questions concerning the identity and mechanisms of interferon antagonists encoded by SARS-CoV-2 will be answered in the months and years to come. Particularly, comparative analyses of SARS-CoV-2 and SARS-CoV will advance the understanding of SARS-CoV-2 pathogenesis. The new knowledge gained will guide the development of vaccines and anti-SARS-CoV-2 therapeutics."}

{"project":"LitCovid-sentences","denotations":[{"id":"T408","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"T409","span":{"begin":98,"end":205},"obj":"Sentence"},{"id":"T410","span":{"begin":206,"end":261},"obj":"Sentence"},{"id":"T411","span":{"begin":262,"end":414},"obj":"Sentence"},{"id":"T412","span":{"begin":415,"end":531},"obj":"Sentence"},{"id":"T413","span":{"begin":532,"end":667},"obj":"Sentence"},{"id":"T414","span":{"begin":668,"end":829},"obj":"Sentence"},{"id":"T415","span":{"begin":830,"end":950},"obj":"Sentence"},{"id":"T416","span":{"begin":951,"end":1048},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The interplay between SARS-CoV-2 and host antiviral defence is at the core of viral pathogenesis. It also determines the infection outcome and might explain the existence and risk of asymptomatic carriers. SARS-CoV-2 is very similar to SARS-CoV in many aspects. Lessons from other human pathogenic viruses including SARS-CoV, community-acquired HCoVs, influenza viruses, and HIVs are very enlightening and helpful. However, SARS-CoV-2 is also a novel human pathogen that may interact with host antiviral defence in a unique manner. Basic research in the field of SARS-CoV-2-host interaction holds the key to many important questions in disease control and prevention. Many important questions concerning the identity and mechanisms of interferon antagonists encoded by SARS-CoV-2 will be answered in the months and years to come. Particularly, comparative analyses of SARS-CoV-2 and SARS-CoV will advance the understanding of SARS-CoV-2 pathogenesis. The new knowledge gained will guide the development of vaccines and anti-SARS-CoV-2 therapeutics."}

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