PMC:7103735 / 42366-45706
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T154 | 12-16 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T155 | 86-94 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T156 | 295-304 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T157 | 312-335 | Body_part | denotes | lower respiratory tract | http://purl.org/sig/ont/fma/fma45662 |
| T158 | 346-353 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T159 | 393-402 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T160 | 414-425 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T161 | 426-432 | Body_part | denotes | (IL) 1 | http://purl.org/sig/ont/fma/fma86583 |
| T162 | 427-429 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T163 | 469-477 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T164 | 492-507 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T165 | 502-507 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T166 | 512-518 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T167 | 546-550 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T168 | 546-548 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T169 | 601-605 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T170 | 601-603 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T171 | 753-758 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T172 | 922-926 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T173 | 922-924 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T174 | 968-972 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T175 | 968-970 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T176 | 1090-1097 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T177 | 1135-1139 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T178 | 1135-1137 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T179 | 1305-1309 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T180 | 1305-1307 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T181 | 1498-1505 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T182 | 2032-2036 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T183 | 2032-2034 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T184 | 2071-2079 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T185 | 2133-2141 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T186 | 2154-2158 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T187 | 2154-2156 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T188 | 2217-2226 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T189 | 2264-2266 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T190 | 2625-2629 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T191 | 2625-2627 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T192 | 2696-2700 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T193 | 2696-2698 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T194 | 2801-2809 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T195 | 3065-3069 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T196 | 3065-3067 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T197 | 3109-3116 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T198 | 3171-3175 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T199 | 3171-3173 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T200 | 3177-3190 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
| T201 | 3197-3216 | Body_part | denotes | lipopolysaccharides | http://purl.org/sig/ont/fma/fma82785 |
| T202 | 3264-3271 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T33 | 312-335 | Body_part | denotes | lower respiratory tract | http://purl.obolibrary.org/obo/UBERON_0001558 |
| T34 | 318-335 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T35 | 512-518 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p59914s16 | 1090-1097 | Protein | denotes | protein |
| p59916s1 | 1241-1251 | PosReg | denotes | stimulates |
| p59916s10 | 1287-1297 | PosReg | denotes | activation |
| p59916s12 | 1301-1307 | MPA | denotes | pro-IL |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T395 | 158-166 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T396 | 158-162 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T397 | 212-216 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T398 | 451-459 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T399 | 451-455 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T400 | 790-793 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T401 | 1011-1015 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T402 | 1487-1495 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T403 | 1487-1491 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T404 | 1597-1605 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T405 | 1597-1601 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T406 | 1667-1675 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T407 | 1667-1671 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T408 | 1765-1768 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T409 | 1790-1798 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T410 | 1790-1794 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T411 | 2050-2058 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T412 | 2050-2054 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T413 | 2397-2405 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T414 | 2490-2498 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T415 | 2490-2494 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T416 | 2532-2540 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T417 | 2532-2536 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T418 | 2881-2884 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T419 | 3072-3075 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T420 | 3130-3134 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T471 | 12-16 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T472 | 68-69 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T473 | 312-335 | http://purl.obolibrary.org/obo/UBERON_0001558 | denotes | lower respiratory tract |
| T474 | 355-357 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
| T475 | 469-477 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T476 | 486-491 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T477 | 492-507 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T478 | 625-635 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T479 | 671-672 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T480 | 727-734 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signals |
| T481 | 753-758 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T482 | 769-778 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T483 | 839-849 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T484 | 866-874 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T485 | 880-887 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signals |
| T486 | 943-949 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T487 | 975-981 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T488 | 1076-1084 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T489 | 1121-1131 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T490 | 1213-1221 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T491 | 1227-1234 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signals |
| T492 | 1256-1257 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T493 | 1258-1268 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T494 | 1287-1297 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T495 | 1430-1440 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T496 | 1455-1461 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T497 | 1475-1483 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T498 | 1634-1644 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T499 | 1819-1820 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T500 | 1870-1878 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T501 | 2471-2472 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T502 | 2520-2530 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T503 | 2545-2553 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T504 | 2559-2565 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T505 | 2582-2588 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T506 | 2592-2602 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T507 | 2664-2665 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T508 | 2666-2676 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T509 | 2966-2975 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T510 | 2983-2993 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T511 | 3128-3129 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T512 | 3161-3162 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T513 | 3177-3190 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
| T514 | 3285-3286 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T149 | 427-429 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T151 | 546-548 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T153 | 601-603 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T155 | 922-924 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T157 | 968-970 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T159 | 1064-1067 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T160 | 1090-1097 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T161 | 1135-1137 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T163 | 1252-1254 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T166 | 1305-1307 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T168 | 1463-1466 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T169 | 1498-1505 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T170 | 1821-1830 | Chemical | denotes | potassium | http://purl.obolibrary.org/obo/CHEBI_26216 |
| T171 | 1848-1851 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T172 | 2032-2034 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T174 | 2071-2079 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T175 | 2154-2156 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T177 | 2264-2266 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T179 | 2290-2298 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T180 | 2299-2309 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T181 | 2625-2627 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T183 | 2660-2662 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T186 | 2696-2698 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T188 | 2753-2762 | Chemical | denotes | potassium | http://purl.obolibrary.org/obo/CHEBI_26216 |
| T189 | 2763-2766 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T190 | 2801-2809 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T191 | 3065-3067 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T193 | 3109-3116 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T194 | 3171-3173 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T196 | 3192-3195 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T199 | 3197-3216 | Chemical | denotes | lipopolysaccharides | http://purl.obolibrary.org/obo/CHEBI_16412 |
| T200 | 3264-3271 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T201 | 3281-3283 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 12-22 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T80 | 32-42 | http://purl.obolibrary.org/obo/GO_0070269 | denotes | pyroptosis |
| T81 | 658-667 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T82 | 928-941 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T83 | 1064-1084 | http://purl.obolibrary.org/obo/GO_0005216 | denotes | ion channel activity |
| T84 | 1068-1084 | http://purl.obolibrary.org/obo/GO_0015267 | denotes | channel activity |
| T85 | 1156-1165 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T86 | 1311-1324 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T87 | 1463-1483 | http://purl.obolibrary.org/obo/GO_0005216 | denotes | ion channel activity |
| T88 | 1467-1483 | http://purl.obolibrary.org/obo/GO_0015267 | denotes | channel activity |
| T89 | 1848-1859 | http://purl.obolibrary.org/obo/GO_0022831 | denotes | ion channel |
| T90 | 2019-2028 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T91 | 2242-2250 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T92 | 2242-2250 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T93 | 2242-2250 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T94 | 2242-2250 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T95 | 2631-2644 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T96 | 2767-2773 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
| T97 | 2767-2773 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
| T98 | 3077-3086 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T99 | 3077-3086 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T100 | 3322-3330 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T101 | 3322-3330 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T102 | 3322-3330 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T103 | 3322-3330 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T350 | 0-180 | Sentence | denotes | One form of cell death known as pyroptosis is one of the results of a proinflammatory cytokine storm, which drives at least in part the high pathogenicity of SARS-CoV and MERS-CoV. |
| T351 | 181-359 | Sentence | denotes | Poor outcomes of patients with SARS and MERS are often associated with exceedingly high levels of proinflammatory cytokines in the lower respiratory tract and other tissues [71]. |
| T352 | 360-531 | Sentence | denotes | The upregulation of inflammatory cytokines, including interleukin (IL) 1β, was observed in SARS-CoV-infected monocyte-derived human dendritic cells and tissue models [72]. |
| T353 | 532-714 | Sentence | denotes | Maturation of IL-1β is generated through proteolytic cleavage of pro-IL-1β by caspase 1, the activation of which requires the formation of a multiprotein complex termed inflammasome. |
| T354 | 715-829 | Sentence | denotes | When danger signals are sensed in the cells, NLRP3 is activated to recruit ASC and facilitate its oligomerization. |
| T355 | 830-998 | Sentence | denotes | For full activation of inflammasome activity, two signals that, respectively, stimulate pro-IL-1β transcription (signal 1) and cleave pro-IL-1β (signal 2) are required. |
| T356 | 999-1174 | Sentence | denotes | Recombinant SARS-CoVs with either deletion of ORF3a or defective ion channel activity of E protein are compromised in the activation of IL-1β maturation and secretion [73,74]. |
| T357 | 1175-1235 | Sentence | denotes | Mechanistically, both ORF3a and E can activate both signals. |
| T358 | 1236-1333 | Sentence | denotes | Both stimulates NF-κB activation, resulting in the activation of pro-IL-1β transcription [73,75]. |
| T359 | 1334-1421 | Sentence | denotes | In particular, ORF3a achieves this through TRAF3-dependent ubiquitination of p105 [73]. |
| T360 | 1422-1551 | Sentence | denotes | For the activation of the second signal, ion channel activity of SARS-CoV E protein promotes assembly of NLRP3 inflammasome [76]. |
| T361 | 1552-1645 | Sentence | denotes | Different mechanisms have been suggested for SARS-CoV ORF3a-mediated inflammasome activation. |
| T362 | 1646-1774 | Sentence | denotes | We demonstrated that SARS-CoV ORF3a promotes NLRP3 inflammasome assembly through TRAF3-dependent K63 ubiquitination of ASC [73]. |
| T363 | 1775-1918 | Sentence | denotes | Alternatively, SARS-CoV ORF3a might provide a potassium flux through its ion channel domain to activate NEK7-dependent NLRP3 inflammasome [77]. |
| T364 | 1919-1995 | Sentence | denotes | Further investigations are required to resolve the discrepancies (Figure 2). |
| T365 | 1996-2277 | Sentence | denotes | Nevertheless, enhanced secretion of IL-1β mediated by SARS-CoV E and ORF3a proteins might contribute to the induction of proinflammatory cytokine storm since IL-1β further promotes the expression of other proinflammatory cytokines such as tumour necrosis factor α and IL-6 [74,75]. |
| T366 | 2278-2406 | Sentence | denotes | Thus, small-molecule inhibitors of NLRP3 inflammasomes such as MCC950 and INF58 might prove useful in the treatment of COVID-19. |
| T367 | 2407-2460 | Sentence | denotes | This merits further preclinical and clinical studies. |
| T368 | 2461-2470 | Sentence | denotes | Figure 2. |
| T369 | 2471-2531 | Sentence | denotes | A working model of SARS-CoV-induced inflammasome activation. |
| T370 | 2532-2604 | Sentence | denotes | SARS-CoV can activate both signal 1 (priming) and signal 2 (activation). |
| T371 | 2605-2677 | Sentence | denotes | Upregulation of pro-IL-1β transcription is achieved by NF-κB activation. |
| T372 | 2678-2732 | Sentence | denotes | Two mechanisms of IL-1β maturation have been proposed. |
| T373 | 2733-2850 | Sentence | denotes | In the first model, potassium ion efflux is promoted by ORF3a and E proteins, leading to NLRP3 inflammasome assembly. |
| T374 | 2851-2940 | Sentence | denotes | Alternatively, ORF3a promotes ASC ubiquitination and consequent assembly of inflammasome. |
| T375 | 2941-2982 | Sentence | denotes | ORG8b interacts with and activates NLRP3. |
| T376 | 2983-3071 | Sentence | denotes | Activation of inflammasome leads to proteolytic cleavage of pro-caspase 1 and pro-IL-1β. |
| T377 | 3072-3135 | Sentence | denotes | ASC, apoptosis-associated speck-like protein containing a CARD. |
| T378 | 3136-3153 | Sentence | denotes | CASP1, caspase 1. |
| T379 | 3154-3170 | Sentence | denotes | IKK, IκB kinase. |
| T380 | 3171-3191 | Sentence | denotes | IL-1, interleukin-1. |
| T381 | 3192-3217 | Sentence | denotes | LPS, lipopolysaccharides. |
| T382 | 3218-3274 | Sentence | denotes | NLRP3, NACHT, LRR, and PYD domains-containing protein 3. |
| T383 | 3275-3307 | Sentence | denotes | NEMO, NF-κB essential modulator. |
| T384 | 3308-3340 | Sentence | denotes | TNF-α, tumour necrosis factor α. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T30 | 86-100 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T31 | 2133-2147 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T32 | 2235-2241 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
| T33 | 3315-3321 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-17031779-27782277 | 355-357 | 17031779 | denotes | 71 |
| 32172672-15858003-27782278 | 527-529 | 15858003 | denotes | 72 |
| 32172672-31034780-27782279 | 1167-1169 | 31034780 | denotes | 73 |
| 32172672-24788150-27782280 | 1170-1172 | 24788150 | denotes | 74 |
| 32172672-31034780-27782281 | 1326-1328 | 31034780 | denotes | 73 |
| 32172672-24198408-27782282 | 1329-1331 | 24198408 | denotes | 75 |
| 32172672-31034780-27782283 | 1417-1419 | 31034780 | denotes | 73 |
| 32172672-26331680-27782284 | 1547-1549 | 26331680 | denotes | 76 |
| 32172672-31034780-27782285 | 1770-1772 | 31034780 | denotes | 73 |
| 32172672-30761102-27782286 | 1914-1916 | 30761102 | denotes | 77 |
| 32172672-24788150-27782287 | 2270-2272 | 24788150 | denotes | 74 |
| 32172672-24198408-27782288 | 2273-2275 | 24198408 | denotes | 75 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1224 | 2621-2630 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1225 | 2660-2665 | Gene | denotes | NF-κB | Gene:4790 |
| 1226 | 2696-2701 | Gene | denotes | IL-1β | Gene:3552 |
| 1227 | 2822-2827 | Gene | denotes | NLRP3 | Gene:114548 |
| 1228 | 2976-2981 | Gene | denotes | NLRP3 | Gene:114548 |
| 1229 | 3061-3070 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1230 | 3072-3075 | Gene | denotes | ASC | Gene:29108 |
| 1231 | 3077-3134 | Gene | denotes | apoptosis-associated speck-like protein containing a CARD | Gene:29108 |
| 1232 | 3136-3141 | Gene | denotes | CASP1 | Gene:834 |
| 1233 | 3143-3152 | Gene | denotes | caspase 1 | Gene:834 |
| 1234 | 3154-3157 | Gene | denotes | IKK | Gene:8517 |
| 1235 | 3171-3175 | Gene | denotes | IL-1 | Gene:3552 |
| 1236 | 3177-3190 | Gene | denotes | interleukin-1 | Gene:3552 |
| 1237 | 3218-3223 | Gene | denotes | NLRP3 | Gene:114548 |
| 1238 | 3225-3273 | Gene | denotes | NACHT, LRR, and PYD domains-containing protein 3 | Gene:114548 |
| 1239 | 3275-3279 | Gene | denotes | NEMO | Gene:8517 |
| 1240 | 3281-3286 | Gene | denotes | NF-κB | Gene:4790 |
| 1241 | 3308-3313 | Gene | denotes | TNF-α | Gene:7124 |
| 1242 | 2490-2498 | Species | denotes | SARS-CoV | Tax:694009 |
| 1243 | 2532-2540 | Species | denotes | SARS-CoV | Tax:694009 |
| 1244 | 2881-2884 | Gene | denotes | ASC | Gene:29108 |
| 1245 | 2753-2762 | Chemical | denotes | potassium | MESH:D011188 |
| 1246 | 3197-3216 | Chemical | denotes | lipopolysaccharides | MESH:D008070 |
| 1247 | 3315-3330 | Disease | denotes | tumour necrosis | MESH:D009336 |
| 1285 | 414-433 | Gene | denotes | interleukin (IL) 1β | Gene:3552 |
| 1286 | 546-551 | Gene | denotes | IL-1β | Gene:3552 |
| 1287 | 597-606 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1288 | 610-619 | Gene | denotes | caspase 1 | Gene:834 |
| 1289 | 760-765 | Gene | denotes | NLRP3 | Gene:114548 |
| 1290 | 790-793 | Gene | denotes | ASC | Gene:29108 |
| 1291 | 918-927 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1292 | 964-973 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1293 | 1135-1140 | Gene | denotes | IL-1β | Gene:3552 |
| 1294 | 1252-1257 | Gene | denotes | NF-κB | Gene:4790 |
| 1295 | 1301-1310 | Gene | denotes | pro-IL-1β | Gene:3553 |
| 1296 | 1377-1382 | Gene | denotes | TRAF3 | Gene:7187 |
| 1297 | 1411-1415 | Gene | denotes | p105 | Gene:4790 |
| 1298 | 1527-1532 | Gene | denotes | NLRP3 | Gene:114548 |
| 1299 | 1691-1696 | Gene | denotes | NLRP3 | Gene:114548 |
| 1300 | 1727-1732 | Gene | denotes | TRAF3 | Gene:7187 |
| 1301 | 1765-1768 | Gene | denotes | ASC | Gene:29108 |
| 1302 | 1879-1883 | Gene | denotes | NEK7 | Gene:140609 |
| 1303 | 1894-1899 | Gene | denotes | NLRP3 | Gene:114548 |
| 1304 | 2032-2037 | Gene | denotes | IL-1β | Gene:3552 |
| 1305 | 2154-2159 | Gene | denotes | IL-1β | Gene:3552 |
| 1306 | 2264-2268 | Gene | denotes | IL-6 | Gene:3569 |
| 1307 | 2313-2318 | Gene | denotes | NLRP3 | Gene:114548 |
| 1308 | 158-166 | Species | denotes | SARS-CoV | Tax:694009 |
| 1309 | 171-179 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1310 | 198-206 | Species | denotes | patients | Tax:9606 |
| 1311 | 486-491 | Species | denotes | human | Tax:9606 |
| 1312 | 1011-1020 | Species | denotes | SARS-CoVs | Tax:694009 |
| 1313 | 1487-1495 | Species | denotes | SARS-CoV | Tax:694009 |
| 1314 | 1597-1605 | Species | denotes | SARS-CoV | Tax:694009 |
| 1315 | 1667-1675 | Species | denotes | SARS-CoV | Tax:694009 |
| 1316 | 1790-1798 | Species | denotes | SARS-CoV | Tax:694009 |
| 1317 | 2050-2058 | Species | denotes | SARS-CoV | Tax:694009 |
| 1318 | 1821-1830 | Chemical | denotes | potassium | MESH:D011188 |
| 1319 | 451-468 | Disease | denotes | SARS-CoV-infected | MESH:C000657245 |
| 1320 | 2235-2250 | Disease | denotes | tumour necrosis | MESH:D009336 |
| 1321 | 2397-2405 | Disease | denotes | COVID-19 | MESH:C000657245 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-17031779-27782277 | 355-357 | 17031779 | denotes | 71 |
| 32172672-15858003-27782278 | 527-529 | 15858003 | denotes | 72 |
| 32172672-31034780-27782279 | 1167-1169 | 31034780 | denotes | 73 |
| 32172672-24788150-27782280 | 1170-1172 | 24788150 | denotes | 74 |
| 32172672-31034780-27782281 | 1326-1328 | 31034780 | denotes | 73 |
| 32172672-24198408-27782282 | 1329-1331 | 24198408 | denotes | 75 |
| 32172672-31034780-27782283 | 1417-1419 | 31034780 | denotes | 73 |
| 32172672-26331680-27782284 | 1547-1549 | 26331680 | denotes | 76 |
| 32172672-31034780-27782285 | 1770-1772 | 31034780 | denotes | 73 |
| 32172672-30761102-27782286 | 1914-1916 | 30761102 | denotes | 77 |
| 32172672-24788150-27782287 | 2270-2272 | 24788150 | denotes | 74 |
| 32172672-24198408-27782288 | 2273-2275 | 24198408 | denotes | 75 |