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PMC:7103735 / 37531-38809 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T126 171-174 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T127 178-189 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T128 190-193 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T129 245-252 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T130 290-293 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T131 492-500 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T132 540-543 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T133 605-608 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T134 651-654 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T135 1032-1040 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p59868s30 381-394 Protein denotes transcription

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T373 1070-1078 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T374 1070-1074 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T420 67-84 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T421 86-103 http://purl.obolibrary.org/obo/PR_000024990 denotes Type I interferon
T422 118-127 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T423 276-286 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T424 506-507 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T425 552-569 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T426 741-746 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T427 770-787 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T428 854-857 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T429 971-972 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T430 1128-1145 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T431 1199-1207 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T110 74-84 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T111 93-103 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T112 245-252 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 492-500 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T114 559-569 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T115 635-654 Chemical denotes double-stranded RNA http://purl.obolibrary.org/obo/CHEBI_67208
T116 656-661 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T117 777-787 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T118 817-822 Chemical denotes dsRNA http://purl.obolibrary.org/obo/CHEBI_67208
T119 1032-1040 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T120 1135-1145 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T42 5-27 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T43 12-27 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T44 86-114 http://purl.obolibrary.org/obo/GO_0032606 denotes Type I interferon production
T45 93-114 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T46 317-326 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T47 341-345 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T48 366-380 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylates
T49 381-401 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T50 381-394 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T51 429-442 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T52 552-580 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T53 559-580 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T54 770-798 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T55 777-798 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T56 1128-1156 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T57 1135-1156 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T317 0-85 Sentence denotes Host innate immune response is the first-line defence triggered by type I interferon.
T318 86-217 Sentence denotes Type I interferon production is activated through the detection of replicating viral RNA by cytoplasmic RNA sensors RIG-I and MDA5.
T319 218-448 Sentence denotes Oligomerization of adaptor protein MAVS is induced by the activation of RNA sensor, leading to the formation of TRAF3-TANK-TBK1/IKKϵ complex, which phosphorylates transcription factor IRF3 and drives type I IFN transcription [49].
T320 449-617 Sentence denotes Highly pathogenic HCoVs often encode viral proteins with a higher capability to antagonize RNA-induced type I interferon production through perturbation of RNA sensing.
T321 618-804 Sentence denotes For one example, double-stranded RNA (dsRNA)-binding domain of MERS-CoV ORF4a is responsible for the suppression of Sendai virus- or poly (I:C)-induced type I interferon production [60].
T322 805-1003 Sentence denotes The gain of dsRNA-binding ability is observed in bat CoV HKU5 but not HKU4, suggesting that the functional gain of MERS-CoV ORF4a and HKU5 ORF4a might be acquired at a later stage in evolution [60].
T323 1004-1278 Sentence denotes For another example, only M proteins from highly pathogenic CoVs, SARS-CoV and MERS-CoV, were reported to potently suppress type I interferon production [61,62], suggesting that the loss of this activity might have taken place during viral evolution, leading to attenuation.

2_test

Id Subject Object Predicate Lexical cue
32172672-26786772-27782263 444-446 26786772 denotes 49
32172672-24522921-27782264 800-802 24522921 denotes 60
32172672-24522921-27782265 999-1001 24522921 denotes 60
32172672-19380580-27782266 1158-1160 19380580 denotes 61
32172672-27094905-27782267 1161-1163 27094905 denotes 62

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1090 202-207 Gene denotes RIG-I Gene:23586
1091 212-216 Gene denotes MDA5 Gene:64135
1092 253-257 Gene denotes MAVS Gene:57506
1093 330-335 Gene denotes TRAF3 Gene:7187
1094 341-345 Gene denotes TBK1 Gene:29110
1095 402-406 Gene denotes IRF3 Gene:3661
1096 929-934 Gene denotes ORF4a Gene:14254596
1097 944-949 Gene denotes ORF4a Gene:14254596
1098 854-857 Gene denotes bat Gene:570
1099 690-695 Gene denotes ORF4a Gene:14254596
1100 425-428 Gene denotes IFN Gene:3439
1101 681-689 Species denotes MERS-CoV Tax:1335626
1102 734-746 Species denotes Sendai virus Tax:11191
1103 858-861 Species denotes CoV Tax:11118
1104 920-928 Species denotes MERS-CoV Tax:1335626
1105 1064-1068 Species denotes CoVs Tax:11118
1106 1070-1078 Species denotes SARS-CoV Tax:694009
1107 1083-1091 Species denotes MERS-CoV Tax:1335626
1108 751-761 Chemical denotes poly (I:C) MESH:D011070
1109 346-350 Disease denotes IKKϵ

MyTest

Id Subject Object Predicate Lexical cue
32172672-26786772-27782263 444-446 26786772 denotes 49
32172672-24522921-27782264 800-802 24522921 denotes 60
32172672-24522921-27782265 999-1001 24522921 denotes 60
32172672-19380580-27782266 1158-1160 19380580 denotes 61
32172672-27094905-27782267 1161-1163 27094905 denotes 62