PMC:7103735 / 34760-35502 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7103735","sourcedb":"PMC","sourceid":"7103735","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7103735","text":"Theoretically, asymptomatic carriers might arise when host antiviral defence is either strong or decoupled. When the immune response effectively limits but could not completely block SARS-CoV-2 replication, asymptomatic shedding might occur. In this scenario, the risk of transmitting to others is relatively low because of a low viral load. Alternatively, if the immune response against SARS-CoV-2 is decoupled from viral replication as in the infection of natural primate hosts with SIVs, the viral load would be higher, posing a higher risk for person-to-person transmission. A careful quantitative analysis of the replication dynamics of SARS-CoV-2 in asymptomatic carriers over time is required to clarify the validity of the two 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