PMC:7103735 / 29769-32111
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T118 | 31-37 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T119 | 1634-1642 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T120 | 1782-1792 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T295 | 54-62 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T296 | 54-58 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T297 | 67-75 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T298 | 67-71 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T299 | 355-363 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T300 | 355-359 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T301 | 465-474 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T302 | 709-717 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T303 | 709-713 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T304 | 774-782 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T305 | 774-778 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T306 | 834-842 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T307 | 834-838 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T308 | 881-889 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T309 | 881-885 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T310 | 993-1001 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T311 | 993-997 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T312 | 1059-1067 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T313 | 1059-1063 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T314 | 1136-1144 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T315 | 1136-1140 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T316 | 1329-1337 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T317 | 1329-1333 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T318 | 1342-1350 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T319 | 1342-1346 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T320 | 1353-1362 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T321 | 1410-1418 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T322 | 1410-1414 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T323 | 1421-1430 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T324 | 1527-1535 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T325 | 1527-1531 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T326 | 1540-1548 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T327 | 1540-1544 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T328 | 1551-1560 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T329 | 1702-1710 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T330 | 1702-1706 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T331 | 1746-1754 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T332 | 1746-1750 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T333 | 2027-2036 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T334 | 2138-2150 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T335 | 2176-2184 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T336 | 2176-2180 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T337 | 2187-2196 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T338 | 2280-2288 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T339 | 2280-2284 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T378 | 38-50 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | organization |
| T379 | 191-194 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T380 | 527-529 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T381 | 669-670 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T382 | 845-848 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T383 | 1069-1071 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T384 | 1489-1490 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T385 | 1616-1617 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T386 | 1681-1687 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T387 | 1888-1889 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T388 | 1905-1915 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T389 | 1961-1962 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T390 | 2119-2120 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T391 | 2264-2270 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T72 | 375-384 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T73 | 1465-1474 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T74 | 1675-1680 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T75 | 1782-1792 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T76 | 1819-1838 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T78 | 1828-1838 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T79 | 1839-1848 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T80 | 1875-1885 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T81 | 1926-1935 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T82 | 1948-1958 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T83 | 2106-2116 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T29 | 1926-1944 | http://purl.obolibrary.org/obo/GO_0051607 | denotes | antiviral response |
| T30 | 2138-2150 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T31 | 2223-2236 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T260 | 0-121 | Sentence | denotes | Comparison of the sequence and genome organization of SARS-CoV and SARS-CoV-2 reveals more similarities than differences. |
| T261 | 122-265 | Sentence | denotes | Overemphasizing the differences in the initial stage of the outbreak has turned out to be counterproductive and very costly in disease control. |
| T262 | 266-410 | Sentence | denotes | The sequence similarities predict that the patterns and modes of the interaction between SARS-CoV-2 and host antiviral defence would be similar. |
| T263 | 411-475 | Sentence | denotes | Indeed, they share many features during the course of infection. |
| T264 | 476-531 | Sentence | denotes | First, they share the same cellular receptor ACE2 [35]. |
| T265 | 532-596 | Sentence | denotes | Second, their transmission routes and patterns are very similar. |
| T266 | 597-689 | Sentence | denotes | While both are transmitted through droplets primarily, close contact is a major risk factor. |
| T267 | 690-791 | Sentence | denotes | The attack rate of SARS-CoV-2 within the family context is even higher than that of SARS-CoV [36,51]. |
| T268 | 792-890 | Sentence | denotes | The faecal–oral route for transmission of SARS-CoV-2 has been reported as in the case of SARS-CoV. |
| T269 | 891-1004 | Sentence | denotes | More studies are required to elucidate the exact role of faecal–oral transmission in the spreading of SARS-CoV-2. |
| T270 | 1005-1294 | Sentence | denotes | Third, superspreading events have been documented for SARS-CoV [52] and are also suspected to have occurred in the transmission of SARS-CoV-2, which could explain the rapid increase in confirmed cases in many places including 691 on the Diamond Princess cruise ship as of 23 February 2020. |
| T271 | 1295-1452 | Sentence | denotes | Fourth, clinical presentations of SARS-CoV and SARS-CoV-2 infection are similar, although symptoms associated with SARS-CoV-2 infection are generally milder. |
| T272 | 1453-1561 | Sentence | denotes | Fifth, host antiviral defence plays a critical role in the course of both SARS-CoV and SARS-CoV-2 infection. |
| T273 | 1562-1665 | Sentence | denotes | For severe cases, immunopathogenesis and induction of a proinflammatory cytokine storm are the culprit. |
| T274 | 1666-1890 | Sentence | denotes | Finally, drugs tested effective for SARS-CoV have been shown to exhibit an anti-SARS-CoV-2 effect; examples include nucleotide analogue Remdesivir [53], protease inhibitors Lopinavir and Ritonavir, as well as interferon α2a. |
| T275 | 1891-2037 | Sentence | denotes | Particularly, activation of innate antiviral response by interferon α2a should have beneficial effects at least in the initial stage of infection. |
| T276 | 2038-2216 | Sentence | denotes | However, cautions should still be observed and the possibility that interferon α2a might exacerbate inflammation during the late phase of SARS-CoV-2 infection cannot be excluded. |
| T277 | 2217-2342 | Sentence | denotes | Other innate immune stimulators should also be tested for anti-SARS-CoV-2 effects in future in vitro and in vivo experiments. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T27 | 1634-1648 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-31986264-27782255 | 784-786 | 31986264 | denotes | 36 |
| 32172672-15030693-27782256 | 1069-1071 | 15030693 | denotes | 52 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 957 | 521-525 | Gene | denotes | ACE2 | Gene:59272 |
| 958 | 1875-1889 | Gene | denotes | interferon α2a | Gene:3440 |
| 959 | 1948-1962 | Gene | denotes | interferon α2a | Gene:3440 |
| 960 | 2106-2120 | Gene | denotes | interferon α2a | Gene:3440 |
| 961 | 54-62 | Species | denotes | SARS-CoV | Tax:694009 |
| 962 | 67-77 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 963 | 355-365 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 964 | 709-719 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 965 | 774-782 | Species | denotes | SARS-CoV | Tax:694009 |
| 966 | 834-844 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 967 | 881-889 | Species | denotes | SARS-CoV | Tax:694009 |
| 968 | 993-1003 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 969 | 1059-1067 | Species | denotes | SARS-CoV | Tax:694009 |
| 970 | 1136-1146 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 971 | 1329-1337 | Species | denotes | SARS-CoV | Tax:694009 |
| 972 | 1527-1535 | Species | denotes | SARS-CoV | Tax:694009 |
| 973 | 1702-1710 | Species | denotes | SARS-CoV | Tax:694009 |
| 974 | 1746-1756 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 975 | 2280-2290 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 976 | 1802-1812 | Chemical | denotes | Remdesivir | MESH:C000606551 |
| 977 | 1839-1848 | Chemical | denotes | Lopinavir | MESH:D061466 |
| 978 | 1853-1862 | Chemical | denotes | Ritonavir | MESH:D019438 |
| 979 | 465-474 | Disease | denotes | infection | MESH:D007239 |
| 980 | 1342-1362 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 981 | 1410-1430 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 982 | 1540-1560 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 983 | 2027-2036 | Disease | denotes | infection | MESH:D007239 |
| 984 | 2138-2150 | Disease | denotes | inflammation | MESH:D007249 |
| 985 | 2176-2196 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32172672-31986264-27782255 | 784-786 | 31986264 | denotes | 36 |
| 32172672-15030693-27782256 | 1069-1071 | 15030693 | denotes | 52 |