PMC:7103696 / 9593-10742 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7103696","sourcedb":"PMC","sourceid":"7103696","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7103696","text":"Currently, there have been more than 330 laboratory-confirmed adult cases of COVID-19 in Shanghai [7]. Most patients (\u003e90%) are in mild or moderate states, and more than 90% of them have been cured and discharged by now. Because no specific drugs have been shown with clear effectiveness in helping the human body to clear the SARS-CoV-2 viruses, the disease severity rate in Shanghai (26 cases, around 9–10%) actually objectively reflected the natural history of the disease, and was comparable with the severity rate at other places outside Hubei Province. All critically ill patients received invasive mechanical ventilation, and six patients received extracorporeal membrane oxygenation (ECMO). We found that in addition to the involvement of the respiratory system, critically ill patients often had systemic involvement of multiple organs, including the heart, kidney, and coagulation system in the early disease course. Sometimes multiple system involvement was observed even at the time of initial hospital admission. Therefore, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very 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