PMC:7103696 / 4126-5484
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T19 | 299-307 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T20 | 524-529 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T21 | 704-712 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T22 | 834-841 | Body_part | denotes | fingers | http://purl.org/sig/ont/fma/fma9666 |
| T23 | 846-850 | Body_part | denotes | toes | http://purl.org/sig/ont/fma/fma70664 |
| T24 | 887-892 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T25 | 910-915 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T26 | 920-927 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T27 | 1280-1285 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 524-529 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T8 | 834-841 | Body_part | denotes | fingers | http://purl.obolibrary.org/obo/UBERON_0002389 |
| T9 | 887-892 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T10 | 910-915 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T11 | 1280-1285 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T24 | 77-92 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T25 | 450-465 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T26 | 1008-1023 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T27 | 1058-1068 | Disease | denotes | COVID-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T28 | 1148-1166 | Disease | denotes | hypercoagulability | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T29 | 1340-1348 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T38 | 524-529 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T39 | 637-648 | http://purl.obolibrary.org/obo/PR_000007299 | denotes | prothrombin |
| T40 | 727-730 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T41 | 887-892 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T42 | 910-915 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T43 | 910-915 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T44 | 910-915 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T45 | 910-915 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T46 | 920-927 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T47 | 920-927 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T48 | 920-927 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T49 | 1073-1081 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T50 | 1280-1285 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T10 | 655-657 | Chemical | denotes | PT | http://purl.obolibrary.org/obo/CHEBI_141395 |
| T11 | 1033-1036 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 9-20 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T3 | 117-128 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T4 | 257-266 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T5 | 1073-1093 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | activate coagulation |
| T6 | 1082-1093 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T7 | 1200-1208 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | clotting |
| T8 | 1209-1218 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T36 | 0-27 | Sentence | denotes | Abnormal coagulation status |
| T37 | 28-157 | Sentence | denotes | Patients at this phase will begin to develop the hypercoagulable state and D-Dimer-based coagulation factors may appear abnormal. |
| T38 | 158-316 | Sentence | denotes | The use of IVIG at this time may provide patients with effective clinical benefits and inhibit the formation of inflammatory factors storm (“cytokine storm”). |
| T39 | 317-484 | Sentence | denotes | LWMH therapy, suggested by colleagues at the Department of Hematology, Peking Union Medical College Hospital, may also alleviate the hypercoagulable state in patients. |
| T40 | 485-713 | Sentence | denotes | During the development of dyspnoea and chest imaging changes from light to severe, the D-dimer increased from mild to significant, along with prolonged prothrombin time (PT) and gradual decrease of fibrinogen (FBG) and platelet. |
| T41 | 714-941 | Sentence | denotes | Recently, it has been observed that some of the non-survivors suffered from ischaemic changes such as ecchymosis of the fingers and toes (Figure 1), at the same time as the organ functions of the heart and kidneys became worse. |
| T42 | 942-1037 | Sentence | denotes | The above manifestations are consistent with the diagnosis of the hypercoagulable phase of DIC. |
| T43 | 1038-1167 | Sentence | denotes | It is believed that COVID-2019 can activate coagulation cascade through various mechanisms, leading to severe hypercoagulability. |
| T44 | 1168-1300 | Sentence | denotes | Early anticoagulation may block clotting formation and reduce microthrombus, thereby reducing the risk of major organ damages [5,6]. |
| T45 | 1301-1310 | Sentence | denotes | Figure 1. |
| T46 | 1311-1358 | Sentence | denotes | Ecchymosis in severe type of COVID-19 patients. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T6 | 0-20 | Phenotype | denotes | Abnormal coagulation | http://purl.obolibrary.org/obo/HP_0001928 |
| T7 | 299-313 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T8 | 511-519 | Phenotype | denotes | dyspnoea | http://purl.obolibrary.org/obo/HP_0002094 |
| T9 | 627-653 | Phenotype | denotes | prolonged prothrombin time | http://purl.obolibrary.org/obo/HP_0008151 |
| T10 | 655-657 | Phenotype | denotes | PT | http://purl.obolibrary.org/obo/HP_0008151 |
| T11 | 816-826 | Phenotype | denotes | ecchymosis | http://purl.obolibrary.org/obo/HP_0031364 |
| T12 | 1148-1166 | Phenotype | denotes | hypercoagulability | http://purl.obolibrary.org/obo/HP_0100724 |
| T13 | 1311-1321 | Phenotype | denotes | Ecchymosis | http://purl.obolibrary.org/obo/HP_0031364 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 91 | 0-27 | Disease | denotes | Abnormal coagulation status | MESH:D025861 |
| 94 | 1349-1357 | Species | denotes | patients | Tax:9606 |
| 95 | 1340-1348 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 105 | 683-693 | Gene | denotes | fibrinogen | Gene:2244 |
| 106 | 28-36 | Species | denotes | Patients | Tax:9606 |
| 107 | 199-207 | Species | denotes | patients | Tax:9606 |
| 108 | 475-483 | Species | denotes | patients | Tax:9606 |
| 109 | 317-321 | Chemical | denotes | LWMH | |
| 110 | 511-519 | Disease | denotes | dyspnoea | MESH:D004417 |
| 111 | 1033-1036 | Disease | denotes | DIC | MESH:D004211 |
| 112 | 1058-1068 | Disease | denotes | COVID-2019 | MESH:C000657245 |
| 113 | 1148-1166 | Disease | denotes | hypercoagulability | MESH:D019851 |