PMC:7102662 / 6824-7278 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T17","span":{"begin":51,"end":56},"obj":"Body_part"},{"id":"T18","span":{"begin":172,"end":177},"obj":"Body_part"},{"id":"T19","span":{"begin":182,"end":187},"obj":"Body_part"},{"id":"T20","span":{"begin":248,"end":257},"obj":"Body_part"},{"id":"T21","span":{"begin":436,"end":440},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma7161"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":172,"end":177},"obj":"Body_part"},{"id":"T10","span":{"begin":436,"end":440},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T67","span":{"begin":19,"end":25},"obj":"Disease"},{"id":"T68","span":{"begin":27,"end":35},"obj":"Disease"},{"id":"T69","span":{"begin":332,"end":340},"obj":"Disease"},{"id":"T70","span":{"begin":441,"end":447},"obj":"Disease"}],"attributes":[{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T39","span":{"begin":45,"end":56},"obj":"http://purl.obolibrary.org/obo/CLO_0053065"},{"id":"T40","span":{"begin":111,"end":112},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T41","span":{"begin":113,"end":121},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T42","span":{"begin":172,"end":177},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T43","span":{"begin":172,"end":177},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T44","span":{"begin":172,"end":177},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T45","span":{"begin":172,"end":177},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T46","span":{"begin":182,"end":187},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T47","span":{"begin":248,"end":257},"obj":"http://purl.obolibrary.org/obo/UBERON_0004535"},{"id":"T48","span":{"begin":384,"end":393},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T49","span":{"begin":436,"end":440},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T50","span":{"begin":436,"end":440},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":71,"end":82},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":234,"end":244},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T11","span":{"begin":384,"end":402},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T12","span":{"begin":384,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T61","span":{"begin":1,"end":188},"obj":"Sentence"},{"id":"T62","span":{"begin":189,"end":316},"obj":"Sentence"},{"id":"T63","span":{"begin":317,"end":454},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T122","span":{"begin":8,"end":18},"obj":"UBERON:0002349"},{"id":"T123","span":{"begin":27,"end":37},"obj":"SP_7"},{"id":"T124","span":{"begin":45,"end":50},"obj":"SP_6;NCBITaxon:9606"},{"id":"T125","span":{"begin":71,"end":102},"obj":"PG_10;PR:000003622"},{"id":"T126","span":{"begin":104,"end":108},"obj":"G_3;PG_10;PR:000003622"},{"id":"T127","span":{"begin":113,"end":121},"obj":"GO:0016020"},{"id":"T128","span":{"begin":159,"end":168},"obj":"GO:0010467"},{"id":"T129","span":{"begin":172,"end":177},"obj":"UBERON:0000948"},{"id":"T130","span":{"begin":182,"end":187},"obj":"UBERON:0000170"},{"id":"T131","span":{"begin":189,"end":193},"obj":"G_3;PG_10;PR:000003622"},{"id":"T132","span":{"begin":234,"end":244},"obj":"GO:0065007"},{"id":"T133","span":{"begin":248,"end":250},"obj":"UBERON:0001017"},{"id":"T134","span":{"begin":332,"end":342},"obj":"SP_7"},{"id":"T135","span":{"begin":346,"end":350},"obj":"G_3;PG_10;PR:000003622"},{"id":"T136","span":{"begin":379,"end":383},"obj":"G_3;PG_10;PR:000003622"},{"id":"T137","span":{"begin":421,"end":431},"obj":"UBERON:0002349"},{"id":"T138","span":{"begin":436,"end":440},"obj":"UBERON:0002048"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"192","span":{"begin":71,"end":102},"obj":"Gene"},{"id":"193","span":{"begin":104,"end":108},"obj":"Gene"},{"id":"194","span":{"begin":189,"end":193},"obj":"Gene"},{"id":"195","span":{"begin":346,"end":350},"obj":"Gene"},{"id":"196","span":{"begin":379,"end":383},"obj":"Gene"},{"id":"197","span":{"begin":27,"end":37},"obj":"Species"},{"id":"198","span":{"begin":45,"end":50},"obj":"Species"},{"id":"199","span":{"begin":332,"end":342},"obj":"Species"},{"id":"200","span":{"begin":8,"end":25},"obj":"Disease"},{"id":"201","span":{"begin":436,"end":447},"obj":"Disease"}],"attributes":[{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Gene:59272"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"Gene:59272"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Gene:59272"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Gene:59272"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Gene:59272"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"Tax:2697049"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Tax:9606"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Tax:2697049"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"MESH:D009202"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D055370"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]."}