PMC:7102662 / 6321-8729
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T14 | 42-45 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T15 | 303-320 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
| T16 | 359-368 | Body_part | denotes | CV system | http://purl.org/sig/ont/fma/fma7161 |
| T17 | 554-559 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T18 | 675-680 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T19 | 685-690 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T20 | 751-760 | Body_part | denotes | CV system | http://purl.org/sig/ont/fma/fma7161 |
| T21 | 939-943 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T22 | 1077-1085 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T23 | 1232-1241 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T24 | 1683-1688 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T25 | 2020-2029 | Body_part | denotes | CV system | http://purl.org/sig/ont/fma/fma7161 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 303-320 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T9 | 675-680 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T10 | 939-943 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T11 | 1132-1138 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T12 | 1683-1688 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T61 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T62 | 131-141 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T63 | 256-260 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T64 | 283-291 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T65 | 347-355 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T66 | 485-493 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T67 | 522-528 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T68 | 530-538 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T69 | 835-843 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T70 | 944-950 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T71 | 971-983 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T72 | 1006-1014 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T73 | 1113-1119 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T74 | 1150-1168 | Disease | denotes | multiorgan failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T75 | 1275-1283 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T76 | 1397-1406 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T77 | 1549-1555 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T78 | 1580-1599 | Disease | denotes | coronary thrombosis | http://purl.obolibrary.org/obo/MONDO_0006716 |
| T79 | 1589-1599 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T80 | 1610-1622 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T81 | 1738-1765 | Disease | denotes | acute myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0004781 |
| T82 | 1744-1765 | Disease | denotes | myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0005068 |
| T83 | 1808-1820 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T84 | 1970-1978 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T85 | 2141-2152 | Disease | denotes | arrhythmias | http://purl.obolibrary.org/obo/MONDO_0007263 |
| T86 | 2239-2250 | Disease | denotes | hypokalemia | http://purl.obolibrary.org/obo/MONDO_0003019 |
| T87 | 2254-2262 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T88 | 2286-2294 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T89 | 2344-2355 | Disease | denotes | Hypokalemia | http://purl.obolibrary.org/obo/MONDO_0003019 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T36 | 24-25 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T37 | 125-130 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T38 | 359-368 | http://purl.obolibrary.org/obo/UBERON_0004535 | denotes | CV system |
| T39 | 548-559 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T40 | 614-615 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T41 | 616-624 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T42 | 675-680 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T43 | 675-680 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T44 | 675-680 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T45 | 675-680 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T46 | 685-690 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T47 | 751-760 | http://purl.obolibrary.org/obo/UBERON_0004535 | denotes | CV system |
| T48 | 887-896 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T49 | 939-943 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T50 | 939-943 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T51 | 1132-1138 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
| T52 | 1683-1688 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T53 | 1683-1688 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T54 | 2020-2029 | http://purl.obolibrary.org/obo/UBERON_0004535 | denotes | CV system |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T5 | 46-50 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T6 | 87-91 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T7 | 574-585 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T8 | 1486-1492 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T9 | 1899-1914 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
| T10 | 1899-1908 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T11 | 1909-1914 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T12 | 1916-1931 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T13 | 2308-2319 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T14 | 2320-2331 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T20 | 1077-1091 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T21 | 1420-1427 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
| T22 | 1444-1463 | Phenotype | denotes | respiratory illness | http://purl.obolibrary.org/obo/HP_0002086 |
| T23 | 1744-1765 | Phenotype | denotes | myocardial infarction | http://purl.obolibrary.org/obo/HP_0001658 |
| T24 | 2141-2152 | Phenotype | denotes | arrhythmias | http://purl.obolibrary.org/obo/HP_0011675 |
| T25 | 2239-2250 | Phenotype | denotes | hypokalemia | http://purl.obolibrary.org/obo/HP_0002900 |
| T26 | 2344-2355 | Phenotype | denotes | Hypokalemia | http://purl.obolibrary.org/obo/HP_0002900 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 737-747 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T11 | 887-905 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T12 | 887-896 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T13 | 971-983 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T14 | 1051-1072 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T15 | 1610-1622 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T16 | 1808-1820 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T57 | 0-63 | Sentence | denotes | SARS-CoV-2 is caused by a novel enveloped RNA beta-coronavirus. |
| T58 | 64-293 | Sentence | denotes | Seven species of these beta-coronaviruses are known to cause human infections, with four mainly causing mild flulike symptoms and the remaining three resulting in potentially fatal illnesses (SARS, MERS and the ongoing COVID-19). |
| T59 | 294-412 | Sentence | denotes | Although respiratory tract is the primary target for SARS-CoV-2, CV system may get involved in several different ways. |
| T60 | 413-502 | Sentence | denotes | Following are the common mechanisms responsible for CV complications in COVID-19 [3,4]-1. |
| T61 | 504-691 | Sentence | denotes | Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs. |
| T62 | 692-819 | Sentence | denotes | ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. |
| T63 | 820-957 | Sentence | denotes | The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4]. |
| T64 | 958-960 | Sentence | denotes | 2. |
| T65 | 962-1169 | Sentence | denotes | Systemic inflammation- More severe forms of COVID-19 are characterized by acute systemic inflammatory response and cytokine storm, which can result in injury to multiple organs leading to multiorgan failure. |
| T66 | 1170-1290 | Sentence | denotes | Studies have shown high circulatory levels of proinflammatory cytokines in patients with severe/critical COVID-19 [5,6]. |
| T67 | 1291-1293 | Sentence | denotes | 3. |
| T68 | 1295-1556 | Sentence | denotes | Altered myocardial demand-supply ratio- Increased cardiometabolic demand associated with the systemic infection coupled with hypoxia caused by acute respiratory illness can impair myocardial oxygen demand-supply relationship and lead to acute myocardial injury. |
| T69 | 1557-1559 | Sentence | denotes | 4. |
| T70 | 1561-1766 | Sentence | denotes | Plaque rupture and coronary thrombosis- Systemic inflammation as well as increased shear stress due to increased coronary blood flow can precipitate plaque rupture resulting in acute myocardial infarction. |
| T71 | 1767-1848 | Sentence | denotes | Prothrombotic milieu created by systemic inflammation further increases the risk. |
| T72 | 1849-1851 | Sentence | denotes | 5. |
| T73 | 1853-2030 | Sentence | denotes | Adverse effects of various therapies- Various antiviral drugs, corticosteroids and other therapies aimed at treating COVID-19 can also have deleterious effects on the CV system. |
| T74 | 2031-2033 | Sentence | denotes | 6. |
| T75 | 2035-2204 | Sentence | denotes | Electrolyte imbalances- Electrolyte imbalances can occur in any critical systemic illness and precipitate arrhythmias, esp. in patients with underlying cardiac disorder. |
| T76 | 2205-2343 | Sentence | denotes | There is particular concern about hypokalemia in COVID-19, due to interaction of SARS-CoV-2 with renin-angiotensin-aldosterone system [7]. |
| T77 | 2344-2408 | Sentence | denotes | Hypokalemia increases vulnerability to various tachyarrhythmias. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T111 | 0-10 | SP_7 | denotes | SARS-CoV-2 |
| T112 | 51-62 | NCBITaxon:11118 | denotes | coronavirus |
| T113 | 70-77 | NCBITaxon:species | denotes | species |
| T114 | 92-105 | NCBITaxon:11118 | denotes | coronaviruses |
| T115 | 125-130 | SP_6;NCBITaxon:9606 | denotes | human |
| T116 | 256-260 | SP_10 | denotes | SARS |
| T117 | 262-266 | SP_9 | denotes | MERS |
| T118 | 283-291 | SP_7 | denotes | COVID-19 |
| T119 | 303-320 | UBERON:0000065 | denotes | respiratory tract |
| T120 | 347-357 | SP_7 | denotes | SARS-CoV-2 |
| T121 | 485-493 | SP_7 | denotes | COVID-19 |
| T122 | 511-521 | UBERON:0002349 | denotes | myocardial |
| T123 | 530-540 | SP_7 | denotes | SARS-CoV-2 |
| T124 | 548-553 | SP_6;NCBITaxon:9606 | denotes | human |
| T125 | 574-605 | PG_10;PR:000003622 | denotes | angiotensin-converting enzyme 2 |
| T126 | 607-611 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T127 | 616-624 | GO:0016020 | denotes | membrane |
| T128 | 662-671 | GO:0010467 | denotes | expressed |
| T129 | 675-680 | UBERON:0000948 | denotes | heart |
| T130 | 685-690 | UBERON:0000170 | denotes | lungs |
| T131 | 692-696 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T132 | 737-747 | GO:0065007 | denotes | regulation |
| T133 | 751-753 | UBERON:0001017 | denotes | CV |
| T134 | 835-845 | SP_7 | denotes | SARS-CoV-2 |
| T135 | 849-853 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T136 | 882-886 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T137 | 924-934 | UBERON:0002349 | denotes | myocardial |
| T138 | 939-943 | UBERON:0002048 | denotes | lung |
| T177 | 1006-1014 | SP_7 | denotes | COVID-19 |
| T178 | 1132-1138 | UBERON:0000062 | denotes | organs |
| T179 | 1150-1160 | UBERON:0000062 | denotes | multiorgan |
| T180 | 1275-1283 | SP_7 | denotes | COVID-19 |
| T181 | 1303-1313 | UBERON:0002349 | denotes | myocardial |
| T182 | 1444-1455 | UBERON:0001004 | denotes | respiratory |
| T183 | 1475-1485 | UBERON:0002349 | denotes | myocardial |
| T184 | 1538-1548 | UBERON:0002349 | denotes | myocardial |
| T185 | 1580-1588 | UBERON:0005985 | denotes | coronary |
| T186 | 1589-1599 | GO:0007596 | denotes | thrombosis |
| T187 | 1674-1682 | UBERON:0005985 | denotes | coronary |
| T188 | 1683-1688 | UBERON:0000178 | denotes | blood |
| T189 | 1744-1754 | UBERON:0002349 | denotes | myocardial |
| T190 | 1767-1780 | GO:0007596 | denotes | Prothrombotic |
| T191 | 1909-1914 | CHEBI:36044;CHEBI:36044 | denotes | drugs |
| T192 | 1916-1931 | CHEBI:50858;CHEBI:50858 | denotes | corticosteroids |
| T193 | 1970-1978 | SP_7 | denotes | COVID-19 |
| T194 | 2187-2194 | UBERON:0000948 | denotes | cardiac |
| T195 | 2254-2262 | SP_7 | denotes | COVID-19 |
| T196 | 2286-2296 | SP_7 | denotes | SARS-CoV-2 |
| T197 | 2302-2307 | PR:000013883 | denotes | renin |
| T90623 | 1502-1510 | SP_7 | denotes | pply rel |
| T3419 | 1556-1564 | UBERON:0000948 | denotes | 4. Pla |
| T78722 | 1812-1820 | SP_7 | denotes | ammation |
| T53635 | 1825-1834 | GO:0007612 | denotes | her incre |
| T94419 | 1854-1865 | NCBITaxon:11118 | denotes | dverse effe |
| T38989 | 1884-1889 | SP_10 | denotes | apies |
| T67414 | 1927-1931 | SP_9 | denotes | oids |
| T60021 | 2161-2169 | SP_7 | denotes | patient |
| T3699 | 2193-2201 | SP_7 | denotes | c disord |
| T86101 | 2208-2219 | NCBITaxon:11118 | denotes | re is parti |
| T88588 | 2252-2259 | UBERON:0000948 | denotes | n COVID |
| T53986 | 2263-2277 | UBERON:0004535 | denotes | due to intera |
| T35855 | 2295-2305 | UBERON:0002349 | denotes | 2 with ren |
| T55568 | 2335-2340 | UBERON:0000948 | denotes | tem [ |
| T45400 | 2404-2408 | SP_10 | denotes | ias. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32247212-31986264-25241178 | 1287-1288 | 31986264 | denotes | 6 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 192 | 574-605 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 193 | 607-611 | Gene | denotes | ACE2 | Gene:59272 |
| 194 | 692-696 | Gene | denotes | ACE2 | Gene:59272 |
| 195 | 849-853 | Gene | denotes | ACE2 | Gene:59272 |
| 196 | 882-886 | Gene | denotes | ACE2 | Gene:59272 |
| 197 | 530-540 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 198 | 548-553 | Species | denotes | human | Tax:9606 |
| 199 | 835-845 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 200 | 511-528 | Disease | denotes | myocardial injury | MESH:D009202 |
| 201 | 939-950 | Disease | denotes | lung injury | MESH:D055370 |
| 206 | 1245-1253 | Species | denotes | patients | Tax:9606 |
| 207 | 971-983 | Disease | denotes | inflammation | MESH:D007249 |
| 208 | 1006-1014 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 209 | 1275-1283 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 215 | 1486-1492 | Chemical | denotes | oxygen | MESH:D010100 |
| 216 | 1388-1406 | Disease | denotes | systemic infection | MESH:D007239 |
| 217 | 1420-1427 | Disease | denotes | hypoxia | MESH:D000860 |
| 218 | 1444-1463 | Disease | denotes | respiratory illness | MESH:D012140 |
| 219 | 1538-1555 | Disease | denotes | myocardial injury | MESH:D009202 |
| 224 | 1580-1599 | Disease | denotes | coronary thrombosis | MESH:D003328 |
| 225 | 1610-1622 | Disease | denotes | inflammation | MESH:D007249 |
| 226 | 1744-1765 | Disease | denotes | myocardial infarction | MESH:D009203 |
| 227 | 1808-1820 | Disease | denotes | inflammation | MESH:D007249 |
| 229 | 1970-1978 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 241 | 2154-2157 | Gene | denotes | esp | Gene:148713 |
| 242 | 2162-2170 | Species | denotes | patients | Tax:9606 |
| 243 | 2286-2296 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 244 | 2320-2331 | Chemical | denotes | aldosterone | MESH:D000450 |
| 245 | 2108-2124 | Disease | denotes | systemic illness | MESH:D002908 |
| 246 | 2141-2152 | Disease | denotes | arrhythmias | MESH:D001145 |
| 247 | 2187-2203 | Disease | denotes | cardiac disorder | MESH:D006331 |
| 248 | 2239-2250 | Disease | denotes | hypokalemia | MESH:D007008 |
| 249 | 2254-2262 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 250 | 2344-2355 | Disease | denotes | Hypokalemia | MESH:D007008 |
| 251 | 2391-2407 | Disease | denotes | tachyarrhythmias | MESH:D013610 |
| 262 | 0-10 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 263 | 46-62 | Species | denotes | beta-coronavirus | Tax:694002 |
| 264 | 87-105 | Species | denotes | beta-coronaviruses | Tax:694002 |
| 265 | 125-130 | Species | denotes | human | Tax:9606 |
| 266 | 347-357 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 267 | 131-141 | Disease | denotes | infections | MESH:D007239 |
| 268 | 173-189 | Disease | denotes | flulike symptoms | MESH:D051271 |
| 269 | 262-266 | Disease | denotes | MERS | MESH:D018352 |
| 270 | 283-291 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 271 | 485-493 | Disease | denotes | COVID-19 | MESH:C000657245 |