PMC:7102662 / 17992-18861 JSON TXT

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LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T162","span":{"begin":141,"end":156},"obj":"Disease"},{"id":"T163","span":{"begin":147,"end":156},"obj":"Disease"}],"attributes":[{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T30","span":{"begin":196,"end":201},"obj":"Chemical"},{"id":"T31","span":{"begin":245,"end":250},"obj":"Chemical"},{"id":"T32","span":{"begin":335,"end":346},"obj":"Chemical"},{"id":"T33","span":{"begin":347,"end":365},"obj":"Chemical"},{"id":"T34","span":{"begin":370,"end":382},"obj":"Chemical"},{"id":"T35","span":{"begin":483,"end":488},"obj":"Chemical"},{"id":"T36","span":{"begin":641,"end":652},"obj":"Chemical"},{"id":"T37","span":{"begin":653,"end":671},"obj":"Chemical"},{"id":"T38","span":{"begin":826,"end":830},"obj":"Chemical"}],"attributes":[{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_2948"},{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T47","span":{"begin":502,"end":521},"obj":"Phenotype"},{"id":"T48","span":{"begin":849,"end":868},"obj":"Phenotype"}],"attributes":[{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0001657"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0001657"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":141,"end":156},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T149","span":{"begin":0,"end":157},"obj":"Sentence"},{"id":"T150","span":{"begin":158,"end":319},"obj":"Sentence"},{"id":"T151","span":{"begin":320,"end":471},"obj":"Sentence"},{"id":"T152","span":{"begin":472,"end":586},"obj":"Sentence"},{"id":"T153","span":{"begin":587,"end":869},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}

LitCovid-PMC-OGER-BB

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"518","span":{"begin":744,"end":747},"obj":"Gene"},{"id":"519","span":{"begin":28,"end":36},"obj":"Species"},{"id":"520","span":{"begin":752,"end":760},"obj":"Species"},{"id":"521","span":{"begin":335,"end":346},"obj":"Chemical"},{"id":"522","span":{"begin":347,"end":365},"obj":"Chemical"},{"id":"523","span":{"begin":370,"end":382},"obj":"Chemical"},{"id":"524","span":{"begin":641,"end":652},"obj":"Chemical"},{"id":"525","span":{"begin":653,"end":671},"obj":"Chemical"},{"id":"526","span":{"begin":141,"end":156},"obj":"Disease"},{"id":"527","span":{"begin":766,"end":794},"obj":"Disease"}],"attributes":[{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Gene:148713"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"Tax:9606"},{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"Tax:9606"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"MESH:D002738"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"MESH:D006886"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"MESH:D001379"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"MESH:D002738"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"MESH:D006886"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"MESH:D001102"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"MESH:D008107"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection. Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done. More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20]. Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents. Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval."}