PMC:7102662 / 10999-13470
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T27 | 367-377 | Body_part | denotes | troponin I | http://purl.org/sig/ont/fma/fma62340 |
| T28 | 367-375 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
| T29 | 1166-1174 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
| T30 | 1225-1233 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
| T31 | 1416-1425 | Body_part | denotes | troponins | http://purl.org/sig/ont/fma/fma62338 |
| T32 | 1840-1856 | Body_part | denotes | ribonucleic acid | http://purl.org/sig/ont/fma/fma67095 |
| T33 | 1900-1905 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T34 | 2294-2299 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T35 | 2334-2339 | Body_part | denotes | Heart | http://purl.org/sig/ont/fma/fma7088 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T14 | 1900-1905 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T15 | 2294-2299 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T16 | 2334-2339 | Body_part | denotes | Heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T109 | 24-30 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T110 | 48-54 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T111 | 105-113 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T112 | 196-202 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T113 | 513-519 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T114 | 734-740 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T115 | 955-961 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T116 | 1049-1057 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T117 | 1389-1395 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T118 | 1443-1451 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T119 | 1566-1572 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T120 | 1580-1597 | Disease | denotes | viral myocarditis | http://purl.obolibrary.org/obo/MONDO_0023161 |
| T121 | 1586-1597 | Disease | denotes | myocarditis | http://purl.obolibrary.org/obo/MONDO_0004496 |
| T122 | 1624-1636 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T123 | 1771-1775 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T124 | 1795-1799 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T125 | 1956-1962 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T126 | 2017-2059 | Disease | denotes | ST-segment elevation myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0041656 |
| T127 | 2038-2059 | Disease | denotes | myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0005068 |
| T128 | 2063-2071 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T129 | 2294-2307 | Disease | denotes | heart failure | http://purl.obolibrary.org/obo/MONDO_0005252 |
| T130 | 2311-2319 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T131 | 2334-2347 | Disease | denotes | Heart failure | http://purl.obolibrary.org/obo/MONDO_0005252 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 520-523 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T66 | 805-806 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T67 | 962-965 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T68 | 996-997 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T69 | 1234-1237 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T70 | 1501-1504 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T71 | 1714-1715 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T72 | 1810-1812 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T73 | 1873-1875 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T74 | 1894-1899 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T75 | 1900-1905 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T76 | 1900-1905 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T77 | 1900-1905 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T78 | 1900-1905 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T79 | 1970-1975 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T80 | 1986-1989 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T81 | 2017-2019 | http://purl.obolibrary.org/obo/CLO_0009141 | denotes | ST |
| T82 | 2017-2019 | http://purl.obolibrary.org/obo/CLO_0050980 | denotes | ST |
| T83 | 2294-2299 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T84 | 2294-2299 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T85 | 2294-2299 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T86 | 2294-2299 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T87 | 2334-2339 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | Heart |
| T88 | 2334-2339 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | Heart |
| T89 | 2334-2339 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | Heart |
| T90 | 2334-2339 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | Heart |
| T91 | 2364-2366 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T16 | 1840-1856 | Chemical | denotes | ribonucleic acid | http://purl.obolibrary.org/obo/CHEBI_33697 |
| T17 | 1852-1856 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T18 | 2017-2019 | Chemical | denotes | ST | http://purl.obolibrary.org/obo/CHEBI_141393 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T32 | 1586-1597 | Phenotype | denotes | myocarditis | http://purl.obolibrary.org/obo/HP_0012819 |
| T33 | 2017-2037 | Phenotype | denotes | ST-segment elevation | http://purl.obolibrary.org/obo/HP_0012251 |
| T34 | 2038-2059 | Phenotype | denotes | myocardial infarction | http://purl.obolibrary.org/obo/HP_0001658 |
| T35 | 2127-2164 | Phenotype | denotes | left ventricular systolic dysfunction | http://purl.obolibrary.org/obo/HP_0025169 |
| T36 | 2172-2196 | Phenotype | denotes | left ventricular failure | http://purl.obolibrary.org/obo/HP_0005162 |
| T37 | 2201-2218 | Phenotype | denotes | cardiogenic shock | http://purl.obolibrary.org/obo/HP_0030149 |
| T38 | 2294-2307 | Phenotype | denotes | heart failure | http://purl.obolibrary.org/obo/HP_0001635 |
| T39 | 2334-2347 | Phenotype | denotes | Heart failure | http://purl.obolibrary.org/obo/HP_0001635 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 1624-1636 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T93 | 0-30 | Sentence | denotes | 2.2.1 Acute myocardial injury |
| T94 | 31-124 | Sentence | denotes | Acute myocardial injury is the most commonly described CV complication in COVID-19 (Table 1). |
| T95 | 125-316 | Sentence | denotes | Different reports have used different definitions for acute myocardial injury, including rise in cardiac enzymes (different biomarkers and cut-offs) and/or electrocardiographic abnormalities. |
| T96 | 317-473 | Sentence | denotes | However, an elevation of high-sensitivity cardiac troponin I (cTnI) above 99th percentile upper reference limit is the most commonly used definition.Table 1 |
| T97 | 474-634 | Sentence | denotes | The overall incidence of acute cardiac injury has been variable but roughly 8–12% of the positive cases are known to develop significant elevation of cTnI [10]. |
| T98 | 635-904 | Sentence | denotes | The aforementioned meta-analysis of the Chinese studies [4] reported 8% incidence of acute cardiac injury whereas another study including only those patients who had had a definite outcome (death or discharge from hospital) reported 17% incidence of cTnI elevation [5]. |
| T99 | 905-1066 | Sentence | denotes | Regardless of the actual incidence, acute cardiac injury has been consistently shown to be a strong negative prognostic marker in patients with COVID-19 [5,6,8]. |
| T100 | 1067-1185 | Sentence | denotes | The patients admitted to ICU or having severe/fatal illness have several-fold higher likelihood of troponin elevation. |
| T101 | 1186-1324 | Sentence | denotes | In contrast, the incidence of elevated troponin has been very low (only 1–2%) in patients having mild illness not requiring ICU admission. |
| T102 | 1325-1452 | Sentence | denotes | Any of the mechanisms described above can lead to acute cardiac injury and rise in cardiac troponins in patients with COVID-19. |
| T103 | 1453-1677 | Sentence | denotes | The relative role of these different mechanisms has not been described but direct (i.e. non-coronary) myocardial injury due to viral myocarditis or the effect of systemic inflammation appear to be the most common mechanisms. |
| T104 | 1678-1814 | Sentence | denotes | These observations are supported by a previous autopsy study in patients who had died due to SARS during the Toronto SARS outbreak [11]. |
| T105 | 1815-1976 | Sentence | denotes | In this study, the viral ribonucleic acid was detected in 35% of the autopsied human heart samples, providing evidence for direct myocardial injury by the virus. |
| T106 | 1977-2098 | Sentence | denotes | No study has described the incidence of ST-segment elevation myocardial infarction in COVID-19, but it appears to be low. |
| T107 | 2099-2248 | Sentence | denotes | Similarly, the incidence of left ventricular systolic dysfunction, acute left ventricular failure and cardiogenic shock have also not been described. |
| T108 | 2249-2333 | Sentence | denotes | Only one Chinese study reported incidence of heart failure in COVID-19 patients [5]. |
| T109 | 2334-2471 | Sentence | denotes | Heart failure had occurred in 52% of the patients who subsequently died and in 12% of the patients who were discharged from the hospital. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T211 | 13-23 | UBERON:0002349 | denotes | myocardial |
| T212 | 37-47 | UBERON:0002349 | denotes | myocardial |
| T213 | 105-113 | SP_7 | denotes | COVID-19 |
| T214 | 185-195 | UBERON:0002349 | denotes | myocardial |
| T215 | 222-229 | UBERON:0000948 | denotes | cardiac |
| T216 | 359-366 | UBERON:0000948 | denotes | cardiac |
| T217 | 505-512 | UBERON:0000948 | denotes | cardiac |
| T218 | 726-733 | UBERON:0000948 | denotes | cardiac |
| T219 | 825-830 | GO:0016265 | denotes | death |
| T220 | 947-954 | UBERON:0000948 | denotes | cardiac |
| T221 | 1049-1057 | SP_7 | denotes | COVID-19 |
| T222 | 1381-1388 | UBERON:0000948 | denotes | cardiac |
| T223 | 1408-1415 | UBERON:0000948 | denotes | cardiac |
| T224 | 1443-1451 | SP_7 | denotes | COVID-19 |
| T225 | 1545-1553 | UBERON:0001621 | denotes | coronary |
| T226 | 1555-1565 | UBERON:0002349 | denotes | myocardial |
| T227 | 1580-1585 | NCBITaxon:10239 | denotes | viral |
| T228 | 1759-1763 | GO:0016265 | denotes | died |
| T229 | 1771-1775 | SP_10 | denotes | SARS |
| T230 | 1795-1799 | SP_10 | denotes | SARS |
| T231 | 1834-1839 | NCBITaxon:10239 | denotes | viral |
| T232 | 1894-1899 | SP_6;NCBITaxon:9606 | denotes | human |
| T233 | 1900-1905 | UBERON:0000948 | denotes | heart |
| T234 | 1945-1955 | UBERON:0002349 | denotes | myocardial |
| T235 | 1970-1975 | NCBITaxon:10239 | denotes | virus |
| T236 | 2038-2048 | UBERON:0002349 | denotes | myocardial |
| T237 | 2063-2071 | SP_7 | denotes | COVID-19 |
| T238 | 2127-2143 | UBERON:0002084 | denotes | left ventricular |
| T239 | 2172-2188 | UBERON:0002084 | denotes | left ventricular |
| T240 | 2294-2299 | UBERON:0000948 | denotes | heart |
| T241 | 2311-2319 | SP_7 | denotes | COVID-19 |
| T242 | 2334-2339 | UBERON:0000948 | denotes | Heart |
| T243 | 2401-2405 | GO:0016265 | denotes | died |
| T36 | 1381-1388 | UBERON:0000948 | denotes | cardiac |
| T27626 | 1945-1955 | UBERON:0002349 | denotes | myocardial |
| T52612 | 2132-2143 | UBERON:0002082 | denotes | ventricular |
| T27094 | 2172-2188 | UBERON:0002084 | denotes | left ventricular |
| T157 | 40-48 | SP_7 | denotes | cardial |
| T158 | 72-82 | SP_7 | denotes | nly descri |
| T159 | 88-93 | PR:000013883 | denotes | comp |
| T160 | 205-215 | UBERON:0002349 | denotes | ncluding r |
| T161 | 224-234 | SP_7 | denotes | rdiac enzy |
| T162 | 242-247 | SP_6;NCBITaxon:9606 | denotes | feren |
| T163 | 268-301 | PG_10;PR:000003622 | denotes | offs) and/or electrocardiographic |
| T164 | 303-307 | G_3;PG_10;PR:000003622 | denotes | bnor |
| T165 | 312-320 | GO:0016020 | denotes | ies. How |
| T166 | 358-367 | GO:0010467 | denotes | cardiac |
| T167 | 371-376 | UBERON:0000948 | denotes | onin |
| T168 | 381-386 | UBERON:0000170 | denotes | nI) a |
| T169 | 388-392 | G_3;PG_10;PR:000003622 | denotes | ve 9 |
| T170 | 433-443 | GO:0065007 | denotes | he most co |
| T171 | 447-449 | UBERON:0001017 | denotes | ly |
| T172 | 531-541 | SP_7 | denotes | riable but |
| T173 | 545-549 | G_3;PG_10;PR:000003622 | denotes | ghly |
| T174 | 578-582 | G_3;PG_10;PR:000003622 | denotes | are |
| T175 | 620-630 | UBERON:0002349 | denotes | of cTnI [ |
| T176 | 635-639 | UBERON:0002048 | denotes | The |
| T64923 | 705-713 | SP_7 | denotes | % incide |
| T13398 | 830-836 | UBERON:0000062 | denotes | or di |
| T97031 | 848-858 | UBERON:0000062 | denotes | hospital) |
| T12823 | 973-981 | SP_7 | denotes | nsistent |
| T99017 | 1000-1010 | UBERON:0002349 | denotes | rong negat |
| T3576 | 1138-1148 | UBERON:0001004 | denotes | l-fold hig |
| T98428 | 1168-1178 | UBERON:0002349 | denotes | oponin ele |
| T52387 | 1231-1241 | UBERON:0002349 | denotes | in has bee |
| T17293 | 1272-1280 | UBERON:0005985 | denotes | nts havi |
| T14874 | 1281-1291 | GO:0007596 | denotes | g mild ill |
| T22127 | 1366-1374 | UBERON:0005985 | denotes | lead to |
| T81653 | 1375-1380 | UBERON:0000178 | denotes | acute |
| T33438 | 1435-1445 | UBERON:0002349 | denotes | ts with CO |
| T74631 | 1458-1471 | GO:0007596 | denotes | elative role |
| T1706 | 1598-1603 | CHEBI:36044;CHEBI:36044 | denotes | or th |
| T69753 | 1605-1620 | CHEBI:50858;CHEBI:50858 | denotes | effect of syste |
| T40512 | 1658-1666 | SP_7 | denotes | common |
| T95131 | 1874-1881 | UBERON:0000948 | denotes | 5% of t |
| T55330 | 1943-1951 | SP_7 | denotes | t myocar |
| T43403 | 1975-1985 | SP_7 | denotes | . No study |
| T97008 | 1991-1996 | PR:000013883 | denotes | escri |
| T90587 | 2224-2232 | SP_7 | denotes | also not |
| T36067 | 342-350 | SP_7 | denotes | high-sen |
| T8537 | 640-648 | SP_7 | denotes | forement |
| T40400 | 709-716 | UBERON:0000948 | denotes | cidence |
| T31575 | 802-810 | SP_7 | denotes | ad a def |
| T82368 | 1100-1110 | GO:0007567 | denotes | aving seve |
| T24251 | 1117-1124 | UBERON:0000948 | denotes | l illne |
| T24920 | 1191-1199 | SP_7 | denotes | ntrast, |
| T47609 | 1335-1342 | UBERON:0000948 | denotes | mechan |
| T90774 | 1654-1664 | UBERON:0000948 | denotes | most commo |
| T51367 | 1725-1732 | UBERON:0000948 | denotes | autopsy |
| T20059 | 1951-1959 | SP_7 | denotes | dial inj |
| T82666 | 2211-2223 | GO:0042730 | denotes | c shock have |
| T97480 | 2241-2249 | SP_7 | denotes | cribed. |
| T23223 | 2290-2300 | UBERON:0002349 | denotes | of heart |
| T84766 | 2367-2377 | CHEBI:35222;CHEBI:35222 | denotes | of the pa |
| T62908 | 2401-2418 | CHEBI:48561;CHEBI:48561 | denotes | died and in 12% o |
| T65791 | 2444-2452 | SP_7 | denotes | scharged |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32247212-31986264-25241180 | 1061-1062 | 31986264 | denotes | 6 |
| 32247212-19453650-25241181 | 1810-1812 | 19453650 | denotes | 11 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 335 | 13-30 | Disease | denotes | myocardial injury | MESH:D009202 |
| 341 | 359-377 | Gene | denotes | cardiac troponin I | Gene:7137 |
| 342 | 379-383 | Gene | denotes | cTnI | Gene:7137 |
| 343 | 37-54 | Disease | denotes | myocardial injury | MESH:D009202 |
| 344 | 105-113 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 345 | 185-202 | Disease | denotes | myocardial injury | MESH:D009202 |
| 357 | 624-628 | Gene | denotes | cTnI | Gene:7137 |
| 358 | 885-889 | Gene | denotes | cTnI | Gene:7137 |
| 359 | 784-792 | Species | denotes | patients | Tax:9606 |
| 360 | 1035-1043 | Species | denotes | patients | Tax:9606 |
| 361 | 1071-1079 | Species | denotes | patients | Tax:9606 |
| 362 | 1267-1275 | Species | denotes | patients | Tax:9606 |
| 363 | 505-519 | Disease | denotes | cardiac injury | MESH:D006331 |
| 364 | 726-740 | Disease | denotes | cardiac injury | MESH:D006331 |
| 365 | 825-830 | Disease | denotes | death | MESH:D003643 |
| 366 | 947-961 | Disease | denotes | cardiac injury | MESH:D006331 |
| 367 | 1049-1057 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 378 | 1429-1437 | Species | denotes | patients | Tax:9606 |
| 379 | 1742-1750 | Species | denotes | patients | Tax:9606 |
| 380 | 1894-1899 | Species | denotes | human | Tax:9606 |
| 381 | 1381-1404 | Disease | denotes | cardiac injury and rise | MESH:D006331 |
| 382 | 1443-1451 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 383 | 1555-1572 | Disease | denotes | myocardial injury | MESH:D009202 |
| 384 | 1586-1597 | Disease | denotes | myocarditis | MESH:D009205 |
| 385 | 1624-1636 | Disease | denotes | inflammation | MESH:D007249 |
| 386 | 1759-1763 | Disease | denotes | died | MESH:D003643 |
| 387 | 1945-1962 | Disease | denotes | myocardial injury | MESH:D009202 |
| 400 | 2320-2328 | Species | denotes | patients | Tax:9606 |
| 401 | 2375-2383 | Species | denotes | patients | Tax:9606 |
| 402 | 2424-2432 | Species | denotes | patients | Tax:9606 |
| 403 | 2038-2059 | Disease | denotes | myocardial infarction | MESH:D009203 |
| 404 | 2063-2071 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 405 | 2127-2164 | Disease | denotes | left ventricular systolic dysfunction | MESH:D018487 |
| 406 | 2172-2196 | Disease | denotes | left ventricular failure | MESH:D018487 |
| 407 | 2201-2218 | Disease | denotes | cardiogenic shock | MESH:D012770 |
| 408 | 2294-2307 | Disease | denotes | heart failure | MESH:D006333 |
| 409 | 2311-2319 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 410 | 2334-2347 | Disease | denotes | Heart failure | MESH:D006333 |
| 411 | 2401-2405 | Disease | denotes | died | MESH:D003643 |