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PMC:7102599 / 8235-9727 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
268 20-24 Gene denotes ACE2 Gene:59272
269 188-192 Gene denotes ACE2 Gene:59272
270 194-199 Gene denotes hACE2 Gene:59272
271 337-342 Gene denotes hACE2 Gene:59272
272 362-367 Gene denotes hACE2 Gene:59272
273 518-523 Gene denotes furin Gene:5045
274 39-49 Species denotes SARS-CoV-2 Tax:2697049
275 143-154 Species denotes coronavirus Tax:11118
276 160-170 Species denotes SARS-CoV-2 Tax:2697049
277 182-187 Species denotes human Tax:9606
278 229-237 Species denotes SARS-CoV Tax:694009
279 422-432 Species denotes SARS-CoV-2 Tax:2697049
280 436-442 Species denotes humans Tax:9606
281 464-472 Species denotes SARS-CoV Tax:694009
282 563-573 Species denotes SARS-CoV-2 Tax:2697049
283 660-668 Species denotes SARS-CoV Tax:694009
284 679-683 Species denotes CoVs Tax:11118
285 739-749 Species denotes SARS-CoV-2 Tax:2697049
286 896-913 Species denotes influenza viruses Tax:11308
287 929-952 Species denotes Newcastle disease virus Tax:11176
288 1063-1073 Species denotes SARS-CoV-2 Tax:2697049
289 1195-1203 Species denotes SARS-CoV Tax:694009
290 1210-1218 Species denotes MERS-CoV Tax:1335626
291 1244-1252 Species denotes SARS-CoV Tax:694009
292 1323-1333 Species denotes SARS-CoV-2 Tax:2697049
293 1456-1466 Species denotes SARS-CoV-2 Tax:2697049
294 1468-1476 Species denotes SARS-CoV Tax:694009
295 1482-1491 Species denotes SARSr-CoV Tax:694009
296 1255-1260 Species denotes mouse Tax:10090
297 1129-1131 Chemical denotes SB MESH:D000965

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T30 72-77 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T31 786-791 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 1314-1319 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T46 39-47 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 160-168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 229-237 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 422-430 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 464-472 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 563-571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 660-668 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 739-747 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 890-905 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T55 896-905 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T56 929-946 Disease denotes Newcastle disease http://purl.obolibrary.org/obo/MONDO_0005875
T57 1063-1071 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 1195-1203 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 1244-1252 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 1323-1331 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 1456-1464 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 1468-1476 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T92 72-77 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T93 98-99 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 182-187 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T95 436-442 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T96 545-547 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97 548-550 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T98 548-550 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T99 614-615 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 643-648 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T101 786-791 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T102 841-846 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T103 906-913 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T104 947-952 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T105 1255-1260 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T106 1314-1319 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T107 1348-1355 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T40 548-550 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T41 1041-1043 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T10 601-613 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T11 825-832 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T45 0-155 Sentence denotes We report here that ACE2 could mediate SARS-CoV-2 S-mediated entry into cells, establishing it as a functional receptor for this newly emerged coronavirus.
T46 156-344 Sentence denotes The SARS-CoV-2 SB engages human ACE2 (hACE2) with comparable affinity to SARS-CoV SB from viral isolates associated with the 2002–2003 epidemic (i.e., binding with high affinity to hACE2).
T47 345-473 Sentence denotes Tight binding to hACE2 could partially explain the efficient transmission of SARS-CoV-2 in humans, as was the case for SARS-CoV.
T48 474-684 Sentence denotes We identified the presence of an unexpected furin cleavage site at the S1/S2 boundary of SARS-CoV-2 S, which is cleaved during biosynthesis—a novel feature setting this virus apart from SARS-CoV and SARSr-CoVs.
T49 685-996 Sentence denotes Abrogation of this cleavage motif moderately affected SARS-CoV-2 S-mediated entry into VeroE6 or BHK cells but may contribute to expand the tropism of this virus, as reported for several highly pathogenic avian influenza viruses and pathogenic Newcastle disease virus (Klenk and Garten, 1994, Steinhauer, 1999).
T50 997-1221 Sentence denotes We determined cryoelectron microscopy (cryo-EM) structures of the SARS-CoV-2 S ectodomain trimer and reveal that it adopts multiple SB conformations that are reminiscent of previous reports on both SARS-CoV S and MERS-CoV S.
T51 1222-1356 Sentence denotes Finally, we show that SARS-CoV S mouse polyclonal sera potently inhibited entry into target cells of SARS-CoV-2 S pseudotyped viruses.
T52 1357-1492 Sentence denotes Collectively, these results pave the way for designing vaccines eliciting broad protection against SARS-CoV-2, SARS-CoV, and SARSr-CoV.

2_test

Id Subject Object Predicate Lexical cue
32155444-8162439-131523197 972-976 8162439 denotes 1994
32155444-8162439-131523197 972-976 8162439 denotes 1994
32155444-10329563-131523198 990-994 10329563 denotes 1999
32155444-10329563-131523198 990-994 10329563 denotes 1999
32155444-8162439-20753236 972-976 8162439 denotes 1994
32155444-8162439-20753236 972-976 8162439 denotes 1994
32155444-10329563-20753237 990-994 10329563 denotes 1999
32155444-10329563-20753237 990-994 10329563 denotes 1999