PMC:7102591 / 5960-7205
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 188 | 975-989 | Gene | denotes | interleukin-1β | Gene:3553 |
| 189 | 991-996 | Gene | denotes | IL-1β | Gene:3552 |
| 190 | 999-1003 | Gene | denotes | IL-2 | Gene:3558 |
| 191 | 1005-1009 | Gene | denotes | IL-6 | Gene:3569 |
| 192 | 1011-1015 | Gene | denotes | IL-7 | Gene:3574 |
| 193 | 1017-1021 | Gene | denotes | IL-8 | Gene:3576 |
| 194 | 1023-1046 | Gene | denotes | tumor necrosis factor-α | Gene:7124 |
| 195 | 1048-1051 | Gene | denotes | TNF | Gene:7124 |
| 196 | 1070-1093 | Gene | denotes | CXC-chemokine ligand 10 | Gene:3627 |
| 197 | 1095-1101 | Gene | denotes | CXCL10 | Gene:3627 |
| 198 | 1107-1128 | Gene | denotes | CC-chemokine ligand 2 | Gene:6347 |
| 199 | 1130-1134 | Gene | denotes | CCL2 | Gene:6347 |
| 200 | 811-819 | Species | denotes | patients | Tax:9606 |
| 201 | 218-222 | Disease | denotes | ARDS | MESH:D012128 |
| 202 | 387-432 | Disease | denotes | secondary haemophagocytic lymphohistiocytosis | MESH:D060085 |
| 203 | 481-507 | Disease | denotes | hyperinflammatory syndrome | MESH:D061325 |
| 204 | 545-586 | Disease | denotes | hypercytokinaemia with multiorgan failure | MESH:D009102 |
| 205 | 615-631 | Disease | denotes | viral infections | MESH:D001102 |
| 206 | 692-697 | Disease | denotes | fever | MESH:D005334 |
| 207 | 699-732 | Disease | denotes | hyperferritinaemia and cytopenias | MESH:D006402 |
| 208 | 738-759 | Disease | denotes | pulmonary involvement | MESH:D008171 |
| 209 | 771-775 | Disease | denotes | ARDS | MESH:D012128 |
| 210 | 894-902 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 211 | 903-913 | Disease | denotes | infections | MESH:D007239 |
| 212 | 1226-1234 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 213 | 1235-1244 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T26 | 10-13 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T27 | 14-20 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T28 | 42-51 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T29 | 61-64 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T30 | 190-196 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T31 | 279-288 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T32 | 293-303 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T33 | 314-323 | Body_part | denotes | Cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T34 | 828-836 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T35 | 964-973 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T36 | 975-988 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
| T37 | 991-995 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T38 | 999-1003 | Body_part | denotes | IL-2 | http://purl.org/sig/ont/fma/fma84051 |
| T39 | 1058-1068 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T40 | 1070-1083 | Body_part | denotes | CXC-chemokine | http://purl.org/sig/ont/fma/fma241985 |
| T41 | 1074-1083 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T42 | 1107-1119 | Body_part | denotes | CC-chemokine | http://purl.org/sig/ont/fma/fma241983 |
| T43 | 1169-1177 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T70 | 218-222 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T71 | 342-345 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
| T73 | 387-432 | Disease | denotes | secondary haemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T74 | 434-438 | Disease | denotes | sHLH | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T75 | 452-456 | Disease | denotes | sHLH | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T76 | 568-586 | Disease | denotes | multiorgan failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T77 | 615-631 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T78 | 667-671 | Disease | denotes | sHLH | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T79 | 771-775 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T80 | 856-860 | Disease | denotes | sHLH | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T81 | 894-902 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T82 | 903-913 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T83 | 1023-1028 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T84 | 1226-1234 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T85 | 1235-1244 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T47 | 353-354 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T48 | 525-526 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T49 | 826-827 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T50 | 861-864 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T51 | 952-953 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T52 | 975-988 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
| T53 | 999-1003 | http://purl.obolibrary.org/obo/PR_000001379 | denotes | IL-2 |
| T54 | 1017-1021 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T40 | 991-993 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T42 | 999-1001 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T44 | 1005-1007 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T46 | 1011-1013 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T48 | 1017-1019 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T50 | 1074-1093 | Chemical | denotes | chemokine ligand 10 | http://purl.obolibrary.org/obo/CHEBI_138157 |
| T51 | 1084-1090 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T52 | 1095-1101 | Chemical | denotes | CXCL10 | http://purl.obolibrary.org/obo/CHEBI_138157 |
| T53 | 1107-1109 | Chemical | denotes | CC | http://purl.obolibrary.org/obo/CHEBI_28940 |
| T54 | 1120-1126 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 86-97 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T6 | 123-136 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T7 | 615-631 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T8 | 1029-1037 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T9 | 1029-1037 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T10 | 1029-1037 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T11 | 1029-1037 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T33 | 0-202 | Sentence | denotes | The viral RNA genome is released into the cytoplasm, and the RNA is uncoated to allow translation of the two polyproteins, transcription of the sub-genomic RNAs and replication of the viral genome [17]. |
| T34 | 203-440 | Sentence | denotes | Progression to ARDS is associated with the upregulation of pro-inflammatory cytokines and chemokines, known as Cytokines Release Syndrome (CRS), with a pattern very similar to that of secondary haemophagocytic lymphohistiocytosis (sHLH). |
| T35 | 441-640 | Sentence | denotes | In adults, sHLH is an under-recognized, hyperinflammatory syndrome characterized by a massive and fatal hypercytokinaemia with multiorgan failure, most commonly triggered by viral infections [18,19]. |
| T36 | 641-825 | Sentence | denotes | Main clinical features of sHLH include unremitting fever, hyperferritinaemia and cytopenias, and pulmonary involvement (including ARDS) occurring in approximately 50% of patients [20]. |
| T37 | 826-1145 | Sentence | denotes | A cytokine profile resembling sHLH has been reported in most severe COVID-19 infections, characterized by increased levels of a number of cytokines (interleukin-1β [IL-1β], IL-2, IL-6, IL-7, IL-8, tumor necrosis factor-α [TNF]) and chemokines (CXC-chemokine ligand 10 [CXCL10] and CC-chemokine ligand 2 [CCL2]) [21,22]. |
| T38 | 1146-1245 | Sentence | denotes | The management of this cytokine storm is one of the major unmet needs regarding COVID-19 infection. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 314-340 | Phenotype | denotes | Cytokines Release Syndrome | http://purl.obolibrary.org/obo/HP_0033041 |
| T26 | 692-697 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T27 | 699-717 | Phenotype | denotes | hyperferritinaemia | http://purl.obolibrary.org/obo/HP_0003281 |
| T28 | 1023-1028 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T29 | 1169-1183 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32205186-24290661-4826869 | 636-638 | 24290661 | denotes | 19 |
| 32205186-26836913-4826870 | 821-823 | 26836913 | denotes | 20 |