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PMC:7102591 / 29993-31801 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
904 878-880 Gene denotes CS Gene:1431
905 508-516 Species denotes patients Tax:9606
906 711-718 Species denotes patient Tax:9606
907 1011-1020 Species denotes SARS-CoV2 Tax:2697049
908 19-27 Disease denotes COVID-19 MESH:C000657245
909 140-142 Disease denotes RA MESH:D001172
910 167-199 Disease denotes autoimmune inflammatory disorder MESH:D001327
911 201-203 Disease denotes RA MESH:D001172
912 400-410 Disease denotes infections MESH:D007239
913 436-438 Disease denotes RA MESH:D001172
914 505-507 Disease denotes RA MESH:D001172
915 578-586 Disease denotes COVID-19 MESH:C000657245
916 941-956 Disease denotes viral infection MESH:D001102
917 1034-1043 Disease denotes pneumonia MESH:D011014
933 1294-1298 Gene denotes IL-6 Gene:3569
934 1241-1249 Species denotes patients Tax:9606
935 1508-1516 Species denotes patients Tax:9606
936 1633-1642 Species denotes SARS-CoV2 Tax:2697049
937 1045-1056 Chemical denotes Chloroquine MESH:D002738
938 1061-1079 Chemical denotes hydroxychloroquine MESH:D006886
939 1313-1324 Chemical denotes tocilizumab MESH:C502936
940 1328-1337 Chemical denotes sarilumab MESH:C000592401
941 1593-1604 Chemical denotes baricitinib MESH:C000596027
942 1151-1159 Disease denotes COVID-19 MESH:C000657245
943 1160-1170 Disease denotes infections MESH:D007239
944 1228-1237 Disease denotes infection MESH:D007239
945 1255-1257 Disease denotes RA MESH:D001172
946 1418-1427 Disease denotes pneumonia MESH:D011014
947 1792-1807 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T109 878-880 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T110 1670-1686 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T111 1681-1686 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51695s23 920-928 PosReg denotes increase

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T312 19-27 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T313 140-142 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T315 178-199 Disease denotes inflammatory disorder http://purl.obolibrary.org/obo/MONDO_0021166
T316 201-203 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T318 221-231 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T319 400-410 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T320 436-438 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T322 475-485 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T323 505-507 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T325 578-586 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T326 941-956 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T327 947-956 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T328 1011-1015 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T329 1034-1043 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T330 1151-1159 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T331 1160-1170 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T332 1228-1237 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T333 1255-1257 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T335 1418-1427 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T336 1443-1446 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T338 1633-1637 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T339 1792-1807 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T340 1798-1807 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T232 48-49 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 114-115 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 157-158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 212-213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 343-344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 447-455 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T238 1605-1608 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T239 1670-1680 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T240 1681-1686 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T241 1739-1747 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T239 140-142 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T240 201-203 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T241 318-323 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T242 436-438 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T243 505-507 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T244 878-880 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T246 1045-1056 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T247 1061-1079 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T248 1255-1257 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T249 1294-1296 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T251 1299-1309 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T252 1313-1324 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T75 941-956 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T76 1792-1807 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T164 0-14 Sentence denotes 6 Conclusions
T165 15-153 Sentence denotes The COVID-19 epidemic represents a health emergency that is inevitably affecting the management of a complex disease such as RA [115,116].
T166 154-265 Sentence denotes As a chronic autoimmune inflammatory disorder, RA carries a higher infectious risk than the general population.
T167 266-498 Sentence denotes The use of synthetic and biologic disease-modifying drugs is associated with a potential further increase in the incidence of serious infections, but the poor control of RA disease activity is an even greater infectious risk factor.
T168 499-596 Sentence denotes Thus, RA patients should be encouraged to continue their treatment even during COVID-19 outbreak.
T169 597-786 Sentence denotes In our opinion, this strategy is reasonable as it aims to prevent disease flares that can contributes to increase patient burden, disability, poor quality of life, and healthcare use [117].
T170 787-1044 Sentence denotes In addition, the discontinuation of ongoing treatments could lead to the need to introduce CS as bridging therapy, which may further increase the risk of viral infection, as well as being inappropriate for the management of SARS-CoV2 interstitial pneumonia.
T171 1045-1282 Sentence denotes Chloroquine and hydroxychloroquine are currently included in the treatment protocol for the management of COVID-19 infections and might be useful to prevent or mitigate the course of infection in patients with RA taking them as csDMARDs.
T172 1283-1574 Sentence denotes The use of IL-6 inhibitors as tocilizumab or sarilumab seems to be promising for the management of most critical cases of interstitial pneumonia complicated by CRS, but the identification of definite criteria to discriminate patients to be treated with these compounds is still under debate.
T173 1575-1808 Sentence denotes Finally, although baricitinib has the potential to affect SARS-CoV2 penetration into pulmonary epithelial cells, major concerns remain about the inhibition of IFNs activity which could be detrimental in the course of viral infection.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T87 140-142 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T88 201-203 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T89 436-438 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T90 505-507 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T91 1034-1043 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T92 1255-1257 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T93 1418-1427 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32205186-31059844-4826927 144-147 31059844 denotes 115
32205186-29037899-4826928 148-151 29037899 denotes 116
32205186-31639516-4826929 781-784 31639516 denotes 117