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PMC:7102591 / 26561-28716 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
829 198-220 Gene denotes numb-associated kinase Gene:29110
830 222-225 Gene denotes NAK Gene:29110
831 243-274 Gene denotes AP2-associated protein kinase 1 Gene:22848
832 276-280 Gene denotes AAK1 Gene:22848
833 286-312 Gene denotes cyclin G-associated kinase Gene:2580
834 314-317 Gene denotes GAK Gene:2580
835 340-344 Gene denotes AAK1 Gene:22848
836 462-466 Gene denotes AAK1 Gene:22848
837 512-516 Gene denotes AAK1 Gene:22848
838 823-826 Gene denotes NAK Gene:29110
839 1051-1055 Gene denotes AAK1 Gene:22848
840 1060-1063 Gene denotes GAK Gene:2580
841 1213-1224 Gene denotes JAK 1 and 2 Gene:3716
842 1337-1341 Gene denotes IL-6 Gene:3569
843 1758-1762 Gene denotes AAK1 Gene:22848
844 1346-1362 Gene denotes interferon gamma Gene:3458
845 35-45 Species denotes SARS-CoV-2 Tax:2697049
846 693-705 Species denotes Dengue virus Tax:12637
847 707-718 Species denotes Ebola virus Tax:205488
848 724-751 Species denotes respiratory syncytial virus Tax:12814
849 959-966 Species denotes patient Tax:9606
850 576-585 Chemical denotes erlotinib MESH:D000069347
851 587-596 Chemical denotes sunitinib MESH:D000077210
852 598-609 Chemical denotes ruxolitinib MESH:C540383
853 615-625 Chemical denotes fedratinib MESH:C528327
854 1008-1019 Chemical denotes baricitinib MESH:C000596027
855 1226-1237 Chemical denotes baricitinib MESH:C000596027
856 1491-1502 Chemical denotes baricitinib MESH:C000596027
857 1655-1674 Chemical denotes lopinavir/ritonavir MESH:C558899
858 1679-1689 Chemical denotes remdesivir MESH:C000606551
859 1712-1723 Chemical denotes tofacitinib MESH:C479163
860 1892-1904 Chemical denotes upadacitinib MESH:C000613732
861 1908-1918 Chemical denotes filgotinib MESH:C584571
862 2124-2135 Chemical denotes ruxolitinib MESH:C540383
863 671-680 Disease denotes infection MESH:D007239
864 1147-1149 Disease denotes RA MESH:D001172
865 1418-1427 Disease denotes pneumonia MESH:D011014
866 1435-1443 Disease denotes COVID-19 MESH:C000657245
867 1880-1882 Disease denotes RA MESH:D001172
868 1935-1956 Disease denotes coronavirus infection MESH:D018352
869 2089-2097 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T100 62-67 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T101 149-157 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T102 258-265 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 383-387 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T104 388-393 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T105 684-689 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T106 1071-1077 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T107 2029-2037 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T28 383-387 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T290 35-43 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T291 671-680 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T292 693-699 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T293 707-712 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T294 1147-1149 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T296 1322-1325 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T298 1418-1427 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T299 1435-1443 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T300 1880-1882 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T302 1947-1956 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T303 2089-2097 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T200 62-67 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T201 314-317 http://purl.obolibrary.org/obo/CLO_0037126 denotes GAK
T202 372-377 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T203 383-387 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T204 383-387 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T205 388-393 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T206 433-438 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T207 450-453 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T208 684-689 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T209 700-705 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T210 713-718 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T211 746-751 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T212 1060-1063 http://purl.obolibrary.org/obo/CLO_0037126 denotes GAK
T213 1071-1077 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T214 1188-1189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 1346-1362 http://purl.obolibrary.org/obo/PR_000000017 denotes interferon gamma
T216 1566-1567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 1869-1875 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T213 258-265 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T214 576-585 Chemical denotes erlotinib http://purl.obolibrary.org/obo/CHEBI_114785
T215 587-596 Chemical denotes sunitinib http://purl.obolibrary.org/obo/CHEBI_38940
T216 598-609 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T217 998-1007 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T218 1147-1149 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T219 1200-1209 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T220 1337-1339 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T222 1346-1356 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T223 1357-1362 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T224 1521-1524 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T225 1525-1529 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T226 1561-1565 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T227 1631-1646 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T228 1631-1640 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T229 1641-1646 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T230 1655-1674 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T231 1655-1664 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T232 1665-1674 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T233 1679-1689 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T234 1712-1723 Chemical denotes tofacitinib http://purl.obolibrary.org/obo/CHEBI_71200
T235 1846-1856 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T236 1880-1882 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T237 2124-2135 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T53 76-105 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T54 94-105 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T55 135-178 http://purl.obolibrary.org/obo/GO_2000369 denotes regulators of clathrin-mediated endocytosis
T56 149-178 http://purl.obolibrary.org/obo/GO_0072583 denotes clathrin-mediated endocytosis
T57 167-178 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T58 286-292 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T59 1293-1314 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T60 2029-2058 http://purl.obolibrary.org/obo/GO_0072583 denotes clathrin-mediated endocytosis
T61 2047-2058 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T147 0-111 Sentence denotes As previously described in detail, SARS-CoV-2 enters targeted cells through receptor-mediated endocytosis [12].
T148 112-325 Sentence denotes Some of the identified regulators of clathrin-mediated endocytosis are members of the numb-associated kinase (NAK) family, such as AP2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) [101].
T149 326-455 Sentence denotes Inhibition of AAK1 may stop the access of the virus into lung cells and also the intracellular assembly of virus particles [102].
T150 456-536 Sentence denotes Of 47 AAK1 blockers approved for medical use, 6 inhibit AAK1 with high affinity.
T151 537-758 Sentence denotes These include oncologic agents such as erlotinib, sunitinib, ruxolitinib, and fedratinib, which have all been demonstrated to inhibit infection of cells by Dengue virus, Ebola virus, and respiratory syncytial virus [103].
T152 759-977 Sentence denotes Unfortunately, all these compounds are able to produce adequate NAK inhibition only at doses significantly higher than those normally used in clinical practice and therefore potentially toxic for the patient [104,105].
T153 978-1174 Sentence denotes Conversely, the JAK inhibitor baricitinib is able to effectively inhibit AAK1 and GAK at the plasma concentration obtained with the approved dosage for the treatment of RA (2 to 4 mg daily) [106].
T154 1175-1454 Sentence denotes Moreover, as a selective inhibitor of JAK 1 and 2, baricitinib is also able to produce an important dampening of host inflammatory response due to CRS (including IL-6 and interferon gamma) responsible for the more severe forms of interstitial pneumonia during COVID-19 [107,108].
T155 1455-1696 Sentence denotes Finally, the minimal interaction of baricitinib with the relevant CYP drug-metabolising enzymes makes the drug a possible candidate for inclusion in combination protocols with antiviral drugs such as lopinavir/ritonavir and remdesivir [109].
T156 1697-1957 Sentence denotes Interestingly, tofacitinib shows no detectable inhibition of AAK1 [104], whereas currently no data are available on the possible effect of other JAK inhibitors approved or tested for RA (such as upadacitinib or filgotinib) in relation to coronavirus infection.
T157 1958-2155 Sentence denotes Unexpectedly, the only clinical trial evaluating the potential role of clathrin-mediated endocytosis blockade in the management of COVID-19 is currently ongoing with ruxolitinib (ChiCTR2000029580).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T83 1147-1149 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T84 1418-1427 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T85 1880-1882 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370

2_test

Id Subject Object Predicate Lexical cue
32205186-28240606-4826922 753-756 28240606 denotes 103
32205186-29753658-4826923 972-975 29753658 denotes 105
32205186-29545548-4826924 1445-1448 29545548 denotes 107
32205186-29649002-4826925 1449-1452 29649002 denotes 108