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PMC:7102591 / 21223-23181 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
633 5-35 Chemical denotes Chloroquine/hydroxychloroquine
640 460-476 Species denotes SARS coronavirus Tax:694009
641 36-47 Chemical denotes Chloroquine MESH:D002738
642 52-70 Chemical denotes hydroxychloroquine MESH:D006886
643 257-268 Chemical denotes chloroquine MESH:D002738
644 191-222 Disease denotes immuno-rheumatological diseases MESH:D000163
645 233-235 Disease denotes RA MESH:D001172
657 835-840 Gene denotes ACE 2 Gene:59272
658 1338-1346 Species denotes patients Tax:9606
659 640-651 Chemical denotes chloroquine MESH:D002738
660 1059-1070 Chemical denotes chloroquine MESH:D002738
661 1370-1381 Chemical denotes chloroquine MESH:D002738
662 1623-1641 Chemical denotes hydroxychloroquine MESH:D006886
663 1695-1706 Chemical denotes chloroquine MESH:D002738
664 1021-1039 Disease denotes SARS CoV infection MESH:C000657245
665 1210-1218 Disease denotes COVID-19 MESH:C000657245
666 1486-1495 Disease denotes pneumonia MESH:D011014
667 1932-1952 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T77 676-685 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T78 708-712 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T79 1432-1436 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 1432-1436 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51644s32 787-809 MPA denotes terminal glycosylation
p51645s8 915-932 MPA denotes -receptor binding

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T245 233-235 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T247 460-464 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 1021-1025 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 1030-1039 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T250 1210-1218 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T251 1486-1495 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T252 1932-1940 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 1943-1952 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T144 301-304 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T145 441-448 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T146 702-707 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 708-712 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T148 755-763 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T149 910-915 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T150 947-948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T151 1044-1045 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 1071-1074 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T153 1182-1188 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T154 1432-1436 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T155 1432-1436 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T156 1507-1508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T157 1509-1514 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T158 1824-1825 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T169 5-16 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T170 17-35 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T171 36-47 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T172 52-70 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T173 101-106 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T174 233-235 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T175 257-268 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T176 375-379 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T177 640-651 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T178 973-977 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T179 1059-1070 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T180 1275-1280 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T181 1370-1381 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T182 1623-1641 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T183 1695-1706 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T40 410-416 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T41 708-719 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T42 708-719 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T43 708-719 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T44 708-719 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T45 746-763 http://purl.obolibrary.org/obo/GO_0038024 denotes receptor activity
T46 787-809 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T47 796-809 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T119 0-35 Sentence denotes 5.1 Chloroquine/hydroxychloroquine
T120 36-241 Sentence denotes Chloroquine and hydroxychloroquine are widely used anti-malarial drugs with well-known immunomodulatory properties that have extended their use to several immuno-rheumatological diseases including RA [83].
T121 242-342 Sentence denotes The ability of chloroquine to produce an anti-viral effect has been known since the late 1960s [84].
T122 343-599 Sentence denotes Several mechanisms by which the drug is able to interfere with the growth and spread of different viruses (including SARS coronavirus) have been demonstrated in in vitro studies [85], even though the subsequent in vivo experience was controversial [86,87].
T123 600-860 Sentence denotes At clinically admissible concentrations chloroquine is able to increase the endosomal pH required for virus/cell fusion, to inhibit the toll-like receptor activity, and to interfere with terminal glycosylation of the cellular receptor ACE 2 [[88], [89], [90]].
T124 861-1040 Sentence denotes All these functions may negatively influence the virus-receptor binding, resulting in a potential effect of the drug on both entry and post-entry stages of the SARS CoV infection.
T125 1041-1302 Sentence denotes As a consequence, chloroquine has recently been included in at least 10 randomized controlled trials currently ongoing in China, where it is tested for the treatment of COVID-19 under various combination protocols with the anti-viral drugs mentioned above [91].
T126 1303-1607 Sentence denotes Interim results from more than 100 patients have demonstrated that chloroquine is superior to the control treatment in improving lung imaging findings, inhibiting the exacerbation of pneumonia, promoting a virus negative conversion, and shortening the disease course at different levels of severity [92].
T127 1608-1767 Sentence denotes More recently, hydroxychloroquine was demonstrated to be more 3-times more potent than chloroquine in an in vitro study based on pharmacokinetic models (PBPK).
T128 1768-1958 Sentence denotes An oral loading dose of 400 mg twice daily, followed by a maintenance dose of 200 mg given twice daily for 4 days seems to be the best option for the management of SARS-CoV-2 infection [93].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T72 233-235 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T73 1486-1495 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32205186-32034323-4826913 237-239 32034323 denotes 83
32205186-4306296-4826914 338-340 4306296 denotes 84
32205186-21550310-4826915 592-594 21550310 denotes 86
32205186-16115318-4826916 843-845 16115318 denotes 88
32205186-16439323-4826917 855-857 16439323 denotes 90