PMC:7102591 / 13066-13583 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"424","span":{"begin":140,"end":144},"obj":"Gene"},{"id":"425","span":{"begin":167,"end":171},"obj":"Species"},{"id":"426","span":{"begin":305,"end":313},"obj":"Species"},{"id":"427","span":{"begin":77,"end":86},"obj":"Chemical"},{"id":"428","span":{"begin":360,"end":373},"obj":"Chemical"},{"id":"429","span":{"begin":36,"end":52},"obj":"Disease"},{"id":"430","span":{"begin":158,"end":166},"obj":"Disease"},{"id":"431","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"432","span":{"begin":284,"end":293},"obj":"Disease"},{"id":"433","span":{"begin":416,"end":426},"obj":"Disease"},{"id":"434","span":{"begin":434,"end":442},"obj":"Disease"},{"id":"435","span":{"begin":507,"end":516},"obj":"Disease"}],"attributes":[{"id":"A424","pred":"tao:has_database_id","subj":"424","obj":"Gene:302668"},{"id":"A425","pred":"tao:has_database_id","subj":"425","obj":"Tax:10116"},{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Tax:9606"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"MESH:D007052"},{"id":"A428","pred":"tao:has_database_id","subj":"428","obj":"MESH:D000082"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"MESH:D001102"},{"id":"A430","pred":"tao:has_database_id","subj":"430","obj":"MESH:D003920"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"MESH:C000657245"},{"id":"A432","pred":"tao:has_database_id","subj":"432","obj":"MESH:D007239"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:D005334"},{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"MESH:C000657245"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p51590s23","span":{"begin":213,"end":221},"obj":"PosReg"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T173","span":{"begin":36,"end":52},"obj":"Disease"},{"id":"T174","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"T175","span":{"begin":284,"end":293},"obj":"Disease"},{"id":"T176","span":{"begin":434,"end":442},"obj":"Disease"},{"id":"T177","span":{"begin":507,"end":516},"obj":"Disease"}],"attributes":[{"id":"A173","pred":"mondo_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A174","pred":"mondo_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A175","pred":"mondo_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A176","pred":"mondo_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T100","span":{"begin":87,"end":90},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T101","span":{"begin":399,"end":400},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T102","span":{"begin":457,"end":458},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T105","span":{"begin":12,"end":18},"obj":"Chemical"},{"id":"T106","span":{"begin":77,"end":86},"obj":"Chemical"},{"id":"T107","span":{"begin":349,"end":355},"obj":"Chemical"}],"attributes":[{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_35475"},{"id":"A106","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_5855"},{"id":"A107","pred":"chebi_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/CHEBI_35475"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":36,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T68","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T69","span":{"begin":77,"end":319},"obj":"Sentence"},{"id":"T70","span":{"begin":320,"end":517},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T58","span":{"begin":416,"end":421},"obj":"Phenotype"}],"attributes":[{"id":"A58","pred":"hp_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/HP_0001945"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}

{"project":"2_test","denotations":[{"id":"32205186-25896805-4826891","span":{"begin":173,"end":175},"obj":"25896805"}],"text":"The role of NSAIDs in the course of viral infections is still controversial. Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15]. In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection."}