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PMC:7102591 / 1247-4151 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
52 119-129 Species denotes SARS-CoV-2 Tax:2697049
53 156-169 Species denotes coronavirus 2 Tax:2697049
54 325-333 Species denotes SARS-CoV Tax:694009
55 363-373 Species denotes SARS-CoV-2 Tax:2697049
56 540-548 Species denotes patients Tax:9606
57 144-155 Species denotes respiratory Tax:12814
58 47-56 Disease denotes pneumonia MESH:D011014
59 394-403 Disease denotes dry cough MESH:D003371
60 405-410 Disease denotes fever MESH:D005334
61 412-419 Disease denotes dyspnea MESH:D004417
62 424-431 Disease denotes fatigue MESH:D005221
63 448-459 Disease denotes lymphopenia MESH:D008231
64 531-539 Disease denotes infected MESH:D007239
65 619-628 Disease denotes pneumonia MESH:D011014
66 634-649 Disease denotes alveolar damage MESH:D055370
67 687-722 Disease denotes Acute Respiratory Distress Syndrome MESH:D012128
68 724-728 Disease denotes ARDS MESH:D012128
69 739-744 Disease denotes death MESH:D003643
70 911-919 Disease denotes COVID-19 MESH:C000657245
71 1190-1196 Disease denotes deaths MESH:D003643
88 2194-2207 Gene denotes interleukin 6 Gene:3569
89 2209-2213 Gene denotes IL-6 Gene:3569
90 1322-1330 Species denotes patients Tax:9606
91 1521-1529 Species denotes patients Tax:9606
92 2013-2024 Chemical denotes Chloroquine MESH:D002738
93 2029-2047 Chemical denotes hydroxychloroquine MESH:D006886
94 1283-1291 Disease denotes COVID-19 MESH:C000657245
95 1314-1321 Disease denotes fragile MESH:D005600
96 1832-1852 Disease denotes SARS-CoV-2 infection MESH:C000657245
97 1928-1948 Disease denotes rheumatoid arthritis MESH:D001172
98 1950-1952 Disease denotes RA MESH:D001172
99 2003-2011 Disease denotes COVID-19 MESH:C000657245
100 2145-2163 Disease denotes COVID-19 pneumonia MESH:C000657245
101 2345-2356 Disease denotes lung damage MESH:D008171
102 2376-2380 Disease denotes ARDS MESH:D012128
103 2426-2444 Disease denotes SARS-CoV infection MESH:C000657245
108 2541-2549 Species denotes patients Tax:9606
109 2750-2758 Species denotes patients Tax:9606
110 2513-2521 Disease denotes COVID-19 MESH:C000657245
111 2747-2749 Disease denotes RA MESH:D001172

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 300-310 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T3 634-642 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T4 1412-1416 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T5 1778-1782 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T6 2194-2207 Body_part denotes interleukin 6 http://purl.org/sig/ont/fma/fma264829
T7 2194-2205 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T8 2285-2293 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T9 2345-2349 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 1412-1416 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T3 1778-1782 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T4 2345-2349 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T23 47-56 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T24 119-127 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 325-333 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 363-371 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 448-459 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T28 619-628 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T29 687-722 Disease denotes Acute Respiratory Distress Syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T30 693-722 Disease denotes Respiratory Distress Syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T31 724-728 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T32 911-919 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 1283-1291 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 1585-1595 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T35 1832-1840 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 1843-1852 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 1928-1948 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T38 1939-1948 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T39 1950-1952 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T41 2003-2011 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 2145-2153 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T43 2154-2163 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T44 2376-2380 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T45 2426-2444 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T46 2435-2444 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 2513-2521 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 2728-2738 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T49 2747-2749 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 70-71 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 272-273 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 284-289 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 462-468 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4
T10 791-794 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T11 799-800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 858-870 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T13 920-921 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 996-997 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 2194-2207 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin 6
T16 2345-2349 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T17 2345-2349 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T18 2446-2448 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T19 2765-2766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 2778-2783 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T9 300-310 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T10 1659-1683 Chemical denotes immunosuppressive agents http://purl.obolibrary.org/obo/CHEBI_35705
T11 1692-1707 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T12 1754-1759 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T13 1887-1892 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T14 1950-1952 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T15 2013-2024 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T16 2029-2047 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T17 2094-2109 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T18 2094-2103 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T19 2104-2109 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T20 2209-2211 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T22 2747-2749 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T23 2847-2867 Chemical denotes anti-rheumatic drugs http://purl.obolibrary.org/obo/CHEBI_35842
T24 2862-2867 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1816-1828 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T9 0-15 Sentence denotes 1 Introduction
T10 16-223 Sentence denotes In December 2019 a new type of pneumonia supported by a novel member of the coronoviridae family named SARS-CoV-2 (severe acute respiratory coronavirus 2 syndrome) developed from Wuhan Province in China [1].
T11 224-340 Sentence denotes Phylogenetic analysis demonstrated that this is a different virus with ~80% nucleotide identity with SARS-CoV-1 [2].
T12 341-481 Sentence denotes The disease caused by SARS-CoV-2 is characterized by dry cough, fever, dyspnea and fatigue, accompanied by lymphopenia [[3], [4], [5], [6]].
T13 482-749 Sentence denotes In more severe cases (apparently up to 15–20% of infected patients) the picture may become more complicated by the onset of interstitial pneumonia with alveolar damage, which clinically can lead to severe Acute Respiratory Distress Syndrome (ARDS) and even death [7].
T14 750-1026 Sentence denotes Since the initial outbreak, the epidemic has had a rapid global spread worldwide which led the World Health Organization (WHO) to declare the disease now called COVID-19 a Public Health Emergency of International Concern on 30th January 2020 and a pandemic on 11th March 2020.
T15 1027-1201 Sentence denotes The epidemiological picture is constantly evolving, and data updated as of March 17th count 159 countries involved with more than 185,000 cases and 7500 confirmed deaths [8].
T16 1202-1400 Sentence denotes In this context of growing health emergency, clarifying the relationship between COVID-19 and the population of fragile patients suffering from immune-rheumatological diseases is absolutely crucial.
T17 1401-1764 Sentence denotes On the one hand, the rapid and uncontrolled spread of the epidemic can clearly generate even more concerns in rheumatic patients, which are intrinsically characterized by an increased infectious risk due to the disease itself and to the iatrogenic effect of immunosuppressive agents such as corticosteroids and synthetic or biological disease-modifying drugs [9].
T18 1765-2012 Sentence denotes On the other hand, the growing knowledge about the pathogenesis of SARS-CoV-2 infection is leading to the introduction of drugs commonly used for the treatment of rheumatoid arthritis (RA) even for the management of more complex cases of COVID-19.
T19 2013-2169 Sentence denotes Chloroquine and hydroxychloroquine have now been permanently included, alongside antiviral drugs, in protocols for the treatment of COVID-19 pneumonia [10].
T20 2170-2450 Sentence denotes In addition, the use of interleukin 6 (IL-6) blockers seems to be very promising for the management of the massive cytokine storm associated to the development of the typical lung damage and the consequent ARDS occurring in the most aggressive patterns of SARS-CoV infection [11].
T21 2451-2665 Sentence denotes Therefore, waiting for observational data on the incidence of COVID-19 in rheumatological patients, the best strategy to manage immune-rheumatological diseases during this emergency period is still far to be clear.
T22 2666-2904 Sentence denotes The purpose of this review is to provide an overview on viral infectious risk in RA patients, with a particular focus on the knowledge about the current new pandemic and the use of anti-rheumatic drugs in this context of health emergency.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 47-56 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T8 394-403 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T9 405-410 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 412-419 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T11 424-431 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T12 448-459 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T13 619-628 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 693-713 Phenotype denotes Respiratory Distress http://purl.obolibrary.org/obo/HP_0002098
T15 1928-1948 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T16 1950-1952 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T17 2154-2163 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 2285-2299 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T19 2747-2749 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370

2_test

Id Subject Object Predicate Lexical cue
32205186-32015507-4826866 220-221 32015507 denotes 1
32205186-25172238-4826867 1761-1762 25172238 denotes 9