PMC:7102591 / 11473-12343 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"371","span":{"begin":630,"end":632},"obj":"Gene"},{"id":"372","span":{"begin":6,"end":8},"obj":"Gene"},{"id":"373","span":{"begin":355,"end":357},"obj":"Gene"},{"id":"374","span":{"begin":414,"end":423},"obj":"Species"},{"id":"375","span":{"begin":433,"end":441},"obj":"Species"},{"id":"376","span":{"begin":209,"end":220},"obj":"Species"},{"id":"377","span":{"begin":781,"end":790},"obj":"Species"},{"id":"378","span":{"begin":185,"end":201},"obj":"Disease"},{"id":"379","span":{"begin":256,"end":267},"obj":"Disease"},{"id":"380","span":{"begin":286,"end":290},"obj":"Disease"},{"id":"381","span":{"begin":380,"end":412},"obj":"Disease"},{"id":"382","span":{"begin":495,"end":512},"obj":"Disease"},{"id":"383","span":{"begin":525,"end":540},"obj":"Disease"},{"id":"384","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"385","span":{"begin":810,"end":819},"obj":"Disease"}],"attributes":[{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"Gene:1431"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"Gene:1431"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"Gene:1431"},{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"Tax:1335626"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Tax:694009"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Tax:12814"},{"id":"A377","pred":"tao:has_database_id","subj":"377","obj":"Tax:11309"},{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"MESH:D001102"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"MESH:D008171"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"MESH:D012128"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"MESH:D018352"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"MESH:D011014"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"MESH:D055370"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"MESH:D007239"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T55","span":{"begin":6,"end":8},"obj":"Body_part"},{"id":"T56","span":{"begin":20,"end":24},"obj":"Body_part"},{"id":"T57","span":{"begin":113,"end":117},"obj":"Body_part"},{"id":"T58","span":{"begin":209,"end":226},"obj":"Body_part"},{"id":"T59","span":{"begin":256,"end":260},"obj":"Body_part"},{"id":"T60","span":{"begin":355,"end":357},"obj":"Body_part"},{"id":"T61","span":{"begin":495,"end":499},"obj":"Body_part"},{"id":"T62","span":{"begin":525,"end":533},"obj":"Body_part"},{"id":"T63","span":{"begin":630,"end":632},"obj":"Body_part"}],"attributes":[{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma284995"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":20,"end":24},"obj":"Body_part"},{"id":"T17","span":{"begin":113,"end":117},"obj":"Body_part"},{"id":"T18","span":{"begin":209,"end":226},"obj":"Body_part"},{"id":"T19","span":{"begin":256,"end":260},"obj":"Body_part"},{"id":"T20","span":{"begin":495,"end":499},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T160","span":{"begin":185,"end":201},"obj":"Disease"},{"id":"T161","span":{"begin":286,"end":290},"obj":"Disease"},{"id":"T162","span":{"begin":433,"end":441},"obj":"Disease"},{"id":"T163","span":{"begin":500,"end":512},"obj":"Disease"},{"id":"T164","span":{"begin":667,"end":676},"obj":"Disease"},{"id":"T165","span":{"begin":781,"end":790},"obj":"Disease"}],"attributes":[{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A165","pred":"mondo_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T88","span":{"begin":256,"end":260},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T89","span":{"begin":256,"end":260},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T90","span":{"begin":443,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T91","span":{"begin":495,"end":499},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T92","span":{"begin":495,"end":499},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T93","span":{"begin":595,"end":596},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T94","span":{"begin":678,"end":679},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T95","span":{"begin":731,"end":734},"obj":"http://purl.obolibrary.org/obo/CLO_0050884"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T89","span":{"begin":6,"end":8},"obj":"Chemical"},{"id":"T91","span":{"begin":355,"end":357},"obj":"Chemical"},{"id":"T93","span":{"begin":630,"end":632},"obj":"Chemical"},{"id":"T95","span":{"begin":833,"end":835},"obj":"Chemical"}],"attributes":[{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A90","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A92","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A94","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_73811"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T17","span":{"begin":25,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0050777"},{"id":"T18","span":{"begin":37,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T19","span":{"begin":141,"end":162},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T20","span":{"begin":185,"end":201},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T21","span":{"begin":500,"end":512},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-sentences","denotations":[{"id":"T60","span":{"begin":0,"end":296},"obj":"Sentence"},{"id":"T61","span":{"begin":297,"end":546},"obj":"Sentence"},{"id":"T62","span":{"begin":547,"end":677},"obj":"Sentence"},{"id":"T63","span":{"begin":678,"end":870},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T57","span":{"begin":517,"end":540},"obj":"Phenotype"}],"attributes":[{"id":"A57","pred":"hp_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/HP_0033006"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}

{"project":"2_test","denotations":[{"id":"32205186-16195357-4826889","span":{"begin":292,"end":294},"obj":"16195357"}],"text":"Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43]. The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46]. However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection. A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),"}