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PMC:7102591 / 10237-13583 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
333 833-835 Gene denotes CS Gene:1431
334 1208-1210 Gene denotes CS Gene:1431
335 974-976 Gene denotes CS Gene:1431
336 652-654 Gene denotes CS Gene:1431
337 323-325 Gene denotes CS Gene:1431
338 89-91 Gene denotes CS Gene:1431
339 697-705 Species denotes patients Tax:9606
340 811-819 Species denotes patients Tax:9606
341 955-963 Species denotes patients Tax:9606
342 1191-1198 Species denotes patient Tax:9606
343 109-111 Disease denotes RA MESH:D001172
344 292-294 Disease denotes RA MESH:D001172
345 358-370 Disease denotes inflammation MESH:D007249
346 378-380 Disease denotes RA MESH:D001172
347 504-514 Disease denotes infections MESH:D007239
348 592-601 Disease denotes infection MESH:D007239
349 680-690 Disease denotes infections MESH:D007239
350 694-696 Disease denotes RA MESH:D001172
351 794-804 Disease denotes infections MESH:D007239
352 808-810 Disease denotes RA MESH:D001172
353 952-954 Disease denotes RA MESH:D001172
354 1019-1035 Disease denotes viral infections MESH:D001102
355 1127-1144 Disease denotes Zoster infections MESH:D006562
371 1866-1868 Gene denotes CS Gene:1431
372 1242-1244 Gene denotes CS Gene:1431
373 1591-1593 Gene denotes CS Gene:1431
374 1650-1659 Species denotes MERS)-CoV Tax:1335626
375 1669-1677 Species denotes SARS-CoV Tax:694009
376 1445-1456 Species denotes respiratory Tax:12814
377 2017-2026 Species denotes influenza Tax:11309
378 1421-1437 Disease denotes viral infections MESH:D001102
379 1492-1503 Disease denotes lung damage MESH:D008171
380 1522-1526 Disease denotes ARDS MESH:D012128
381 1616-1648 Disease denotes Middle East respiratory syndrome MESH:D018352
382 1731-1748 Disease denotes lung inflammation MESH:D011014
383 1761-1776 Disease denotes alveolar damage MESH:D055370
384 1903-1912 Disease denotes infection MESH:D007239
385 2046-2055 Disease denotes mortality MESH:D003643
399 2598-2600 Gene denotes CS Gene:1431
400 2313-2315 Gene denotes CS Gene:1431
401 2784-2786 Gene denotes CS Gene:1431
402 2481-2483 Gene denotes CS Gene:1431
403 2294-2302 Species denotes patients Tax:9606
404 2414-2422 Species denotes patients Tax:9606
405 2547-2555 Species denotes patients Tax:9606
406 2135-2164 Disease denotes bacterial or fungal infection MESH:D001424
407 2366-2370 Disease denotes ARDS MESH:D012128
408 2561-2569 Disease denotes COVID-19 MESH:C000657245
409 2570-2579 Disease denotes infection MESH:D007239
410 2738-2746 Disease denotes COVID-19 MESH:C000657245
411 2747-2756 Disease denotes infection MESH:D007239
424 2969-2973 Gene denotes ACE2 Gene:302668
425 2996-3000 Species denotes rats Tax:10116
426 3134-3142 Species denotes patients Tax:9606
427 2906-2915 Chemical denotes Ibuprofen MESH:D007052
428 3189-3202 Chemical denotes acetaminophen MESH:D000082
429 2865-2881 Disease denotes viral infections MESH:D001102
430 2987-2995 Disease denotes diabetic MESH:D003920
431 3104-3112 Disease denotes COVID-19 MESH:C000657245
432 3113-3122 Disease denotes infection MESH:D007239
433 3245-3255 Disease denotes fever rise MESH:D005334
434 3263-3271 Disease denotes COVID-19 MESH:C000657245
435 3336-3345 Disease denotes infection MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T49 89-91 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T50 323-325 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T51 652-654 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T52 833-835 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T53 974-976 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T54 1208-1210 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T55 1242-1244 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T56 1256-1260 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T57 1349-1353 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T58 1445-1462 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T59 1492-1496 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T60 1591-1593 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T61 1731-1735 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T62 1761-1769 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T63 1866-1868 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T64 2313-2315 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T65 2481-2483 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T66 2598-2600 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T67 2784-2786 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T16 1256-1260 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T17 1349-1353 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T18 1445-1462 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T19 1492-1496 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 1731-1735 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51590s23 3042-3050 PosReg denotes increase

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T139 109-111 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T141 292-294 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T143 358-370 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T144 378-380 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T146 504-514 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T147 592-601 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T148 680-693 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T149 694-696 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T151 794-807 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T152 808-810 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T154 903-913 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T155 952-954 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T157 1019-1035 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T158 1127-1133 Disease denotes Zoster http://purl.obolibrary.org/obo/MONDO_0005609
T159 1134-1144 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T160 1421-1437 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T161 1522-1526 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T162 1669-1677 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T163 1736-1748 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T164 1903-1912 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T165 2017-2026 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T166 2148-2164 Disease denotes fungal infection http://purl.obolibrary.org/obo/MONDO_0002041
T167 2155-2164 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T168 2366-2370 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T169 2561-2569 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 2570-2579 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T171 2738-2746 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 2747-2756 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T173 2865-2881 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T174 3104-3112 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T175 3113-3122 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T176 3263-3271 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 3336-3345 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T81 35-38 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T82 216-219 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T83 306-308 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T84 720-722 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T85 850-851 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 985-986 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 1052-1053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 1492-1496 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T89 1492-1496 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T90 1679-1681 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T91 1731-1735 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T92 1731-1735 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T93 1831-1832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 1914-1915 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T95 1967-1970 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T96 2178-2182 http://purl.obolibrary.org/obo/CLO_0037048 denotes CI 1
T97 2332-2333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 2399-2400 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 2495-2497 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T100 2916-2919 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T101 3228-3229 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 3286-3287 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69 25-31 Chemical denotes NSAIDs http://purl.obolibrary.org/obo/CHEBI_35475
T70 72-87 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T71 89-91 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T73 109-111 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T74 292-294 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T75 323-325 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T77 378-380 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T78 652-654 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T80 694-696 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T81 808-810 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T82 833-835 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T84 952-954 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T85 974-976 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T87 1208-1210 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T89 1242-1244 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T91 1591-1593 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T93 1866-1868 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T95 2069-2071 Chemical denotes RR http://purl.obolibrary.org/obo/CHEBI_73811
T96 2166-2168 Chemical denotes RR http://purl.obolibrary.org/obo/CHEBI_73811
T97 2313-2315 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T99 2481-2483 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T101 2598-2600 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T103 2784-2786 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462|http://purl.obolibrary.org/obo/CHEBI_50858
T105 2841-2847 Chemical denotes NSAIDs http://purl.obolibrary.org/obo/CHEBI_35475
T106 2906-2915 Chemical denotes Ibuprofen http://purl.obolibrary.org/obo/CHEBI_5855
T107 3178-3184 Chemical denotes NSAIDs http://purl.obolibrary.org/obo/CHEBI_35475

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T15 358-370 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T16 1019-1035 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T17 1261-1288 http://purl.obolibrary.org/obo/GO_0050777 denotes inhibit the immune response
T18 1273-1288 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T19 1377-1398 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T20 1421-1437 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T21 1736-1748 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T22 2865-2881 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T54 0-31 Sentence denotes 4.1 Corticosteroids and NSAIDs
T55 32-310 Sentence denotes It has now been more than 70 years that corticosteroids (CS) are pivotal for RA management and their role as remission inducer and bridging therapy for the management of disease flare has recently been renewed by the latest update of EULAR recommendations for RA treatment [36].
T56 311-610 Sentence denotes Even though CS efficacy in rapidly suppressing inflammation during RA initial course or flares is well recognized [37], their downside is the broad spectrum of adverse events, including severe infections and the high risk of developing comorbidities further increasing the risk of infection [27,38].
T57 611-880 Sentence denotes Although RCTs conducted in the past with CS showed no higher risk of infections in RA patients [[39], [40], [41]], cohort and case-control studies reported increased rates of overall infections in RA patients treated with CS, according to a dose-dependent fashion [42].
T58 881-1036 Sentence denotes The majority of these infectious events are of bacterial etiology, but RA patients receiving CS exhibit a greater risk of developing even viral infections.
T59 1037-1235 Sentence denotes As an example, a 2012 retrospective cohort-study demonstrated an increased risk of Herpes Zoster infections with an incidence rate of 8.54 cases per 1000 patient-years in CS treated population [29].
T60 1236-1532 Sentence denotes Thus, CS on the one hand inhibit the immune response and delay the clearance of the pathogen, while on the other hand they suppress the host inflammatory response, which in the case of viral infections of the respiratory tract is the major responsible for lung damage and occurrence of ARDS [43].
T61 1533-1782 Sentence denotes The latter represented the rational for the widely use of CS for the management of Middle East respiratory syndrome (MERS)-CoV [44] and SARS-CoV [45] outbreaks, both histologically characterized by lung inflammation and diffuse alveolar damage [46].
T62 1783-1913 Sentence denotes However, evidence from the literature points to a predominantly negative effect of CS in the management of this type of infection.
T63 1914-2106 Sentence denotes A 2019 systematic review and meta-analysis including ten observational studies (n = 6548) conducted in influenza reported increased mortality (risk ratio [RR] 1.75, 95% CI 1.3–2.4; p = .0002),
T64 2107-2321 Sentence denotes increased rate of secondary bacterial or fungal infection (RR 2·0, 95% CI 1·0–3·8; p = .04), and longer stay in an intensive care unit (mean difference 2.1, 95% CI 1.2–3.1; p < .0001) in patients receiving CS [47].
T65 2322-2499 Sentence denotes Moreover, a review exploring treatments for ARDS, including six studies with a total of 574 patients, concluded that insufficient evidence exists to recommend CS treatment [48].
T66 2500-2668 Sentence denotes Overall, no clear reason exists to expect that patients with COVID-19 infection will benefit from CS, and they might be more likely to be harmed with such therapy [49].
T67 2669-2828 Sentence denotes In fact, current interim guidance from WHO on clinical management of COVID-19 infection advises against the use of CS unless indicated for another reason [10].
T68 2829-2905 Sentence denotes The role of NSAIDs in the course of viral infections is still controversial.
T69 2906-3148 Sentence denotes Ibuprofen has been demonstrated to induce an overexpression of ACE2 when used in diabetic rats [50] and this effect might theoretically increase the susceptibility and worsen the clinical course of COVID-19 infection in treated patients [15].
T70 3149-3346 Sentence denotes In addition, the use of both NSAIDs and acetaminophen could be associated with a masking of the fever rise during COVID-19, resulting in a delay in diagnosis and proper management of the infection.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T50 109-111 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T51 292-294 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T52 378-380 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T53 497-514 Phenotype denotes severe infections http://purl.obolibrary.org/obo/HP_0032169
T54 694-696 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T55 808-810 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T56 952-954 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T57 1753-1776 Phenotype denotes diffuse alveolar damage http://purl.obolibrary.org/obo/HP_0033006
T58 3245-3250 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945

2_test

Id Subject Object Predicate Lexical cue
32205186-31396235-4826883 426-428 31396235 denotes 37
32205186-23192911-4826884 603-605 23192911 denotes 27
32205186-17870034-4826885 606-608 17870034 denotes 38
32205186-9251634-4826886 708-710 9251634 denotes 39
32205186-22393128-4826887 720-722 22393128 denotes 41
32205186-21884589-4826888 876-878 21884589 denotes 42
32205186-16195357-4826889 1528-1530 16195357 denotes 43
32205186-30917856-4826890 2317-2319 30917856 denotes 47
32205186-25896805-4826891 3002-3004 25896805 denotes 50