PMC:7102583 / 8694-9359 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"331","span":{"begin":103,"end":113},"obj":"Species"},{"id":"332","span":{"begin":549,"end":557},"obj":"Species"},{"id":"333","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"334","span":{"begin":405,"end":414},"obj":"Chemical"},{"id":"335","span":{"begin":16,"end":24},"obj":"Disease"},{"id":"336","span":{"begin":91,"end":99},"obj":"Disease"},{"id":"337","span":{"begin":149,"end":170},"obj":"Disease"},{"id":"338","span":{"begin":278,"end":282},"obj":"Disease"},{"id":"339","span":{"begin":490,"end":502},"obj":"Disease"},{"id":"340","span":{"begin":567,"end":571},"obj":"Disease"},{"id":"341","span":{"begin":610,"end":621},"obj":"Disease"},{"id":"342","span":{"begin":623,"end":627},"obj":"Disease"},{"id":"343","span":{"begin":629,"end":664},"obj":"Disease"}],"attributes":[{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Tax:2697049"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"Tax:9606"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"MESH:D008550"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"MESH:D008550"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"MESH:C000657245"},{"id":"A336","pred":"tao:has_database_id","subj":"336","obj":"MESH:D007239"},{"id":"A337","pred":"tao:has_database_id","subj":"337","obj":"MESH:D006973"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"MESH:D012128"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"MESH:D007249"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"MESH:D012128"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"MESH:D055370"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"MESH:D012128"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":55,"end":64},"obj":"Body_part"},{"id":"T79","span":{"begin":85,"end":90},"obj":"Body_part"},{"id":"T80","span":{"begin":258,"end":266},"obj":"Body_part"},{"id":"T81","span":{"begin":405,"end":414},"obj":"Body_part"},{"id":"T82","span":{"begin":475,"end":488},"obj":"Body_part"},{"id":"T83","span":{"begin":610,"end":614},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma74644"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma74644"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":475,"end":488},"obj":"Body_part"},{"id":"T22","span":{"begin":610,"end":614},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T103","span":{"begin":16,"end":24},"obj":"Disease"},{"id":"T104","span":{"begin":103,"end":111},"obj":"Disease"},{"id":"T105","span":{"begin":158,"end":170},"obj":"Disease"},{"id":"T106","span":{"begin":274,"end":277},"obj":"Disease"},{"id":"T107","span":{"begin":278,"end":282},"obj":"Disease"},{"id":"T108","span":{"begin":490,"end":502},"obj":"Disease"},{"id":"T109","span":{"begin":563,"end":566},"obj":"Disease"},{"id":"T110","span":{"begin":567,"end":571},"obj":"Disease"},{"id":"T111","span":{"begin":599,"end":602},"obj":"Disease"},{"id":"T112","span":{"begin":604,"end":621},"obj":"Disease"},{"id":"T114","span":{"begin":615,"end":621},"obj":"Disease"},{"id":"T115","span":{"begin":623,"end":627},"obj":"Disease"},{"id":"T116","span":{"begin":629,"end":664},"obj":"Disease"},{"id":"T117","span":{"begin":635,"end":664},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A113","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0015796"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T109","span":{"begin":85,"end":90},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T110","span":{"begin":119,"end":120},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T111","span":{"begin":240,"end":250},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T112","span":{"begin":309,"end":310},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T113","span":{"begin":424,"end":425},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T114","span":{"begin":475,"end":488},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T115","span":{"begin":610,"end":614},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T116","span":{"begin":610,"end":614},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T63","span":{"begin":39,"end":47},"obj":"Chemical"},{"id":"T64","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"T65","span":{"begin":405,"end":414},"obj":"Chemical"},{"id":"T66","span":{"begin":434,"end":442},"obj":"Chemical"}],"attributes":[{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_16796"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_16796"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T38","span":{"begin":0,"end":12},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T39","span":{"begin":132,"end":147},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T40","span":{"begin":158,"end":170},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T41","span":{"begin":461,"end":471},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T42","span":{"begin":490,"end":502},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-sentences","denotations":[{"id":"T59","span":{"begin":66,"end":273},"obj":"Sentence"},{"id":"T60","span":{"begin":274,"end":404},"obj":"Sentence"},{"id":"T61","span":{"begin":405,"end":598},"obj":"Sentence"},{"id":"T62","span":{"begin":599,"end":603},"obj":"Sentence"},{"id":"T63","span":{"begin":604,"end":628},"obj":"Sentence"},{"id":"T64","span":{"begin":629,"end":665},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T47","span":{"begin":258,"end":272},"obj":"Phenotype"},{"id":"T48","span":{"begin":274,"end":277},"obj":"Phenotype"},{"id":"T49","span":{"begin":563,"end":566},"obj":"Phenotype"},{"id":"T50","span":{"begin":599,"end":602},"obj":"Phenotype"},{"id":"T51","span":{"begin":604,"end":621},"obj":"Phenotype"},{"id":"T52","span":{"begin":635,"end":655},"obj":"Phenotype"}],"attributes":[{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome."}