PMC:7102583 / 8687-9359 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7102583","sourcedb":"PMC","sourceid":"7102583","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7102583","text":"Fig. 1 Pathogenesis of COVID-19 and potential adjuvant use of melatonin. We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. ALI: Acute lung injury; ARDS: Acute respiratory distress syndrome.","divisions":[{"label":"label","span":{"begin":0,"end":6}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"331","span":{"begin":110,"end":120},"obj":"Species"},{"id":"332","span":{"begin":556,"end":564},"obj":"Species"},{"id":"333","span":{"begin":62,"end":71},"obj":"Chemical"},{"id":"334","span":{"begin":412,"end":421},"obj":"Chemical"},{"id":"335","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"336","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"337","span":{"begin":156,"end":177},"obj":"Disease"},{"id":"338","span":{"begin":285,"end":289},"obj":"Disease"},{"id":"339","span":{"begin":497,"end":509},"obj":"Disease"},{"id":"340","span":{"begin":574,"end":578},"obj":"Disease"},{"id":"341","span":{"begin":617,"end":628},"obj":"Disease"},{"id":"342","span":{"begin":630,"end":634},"obj":"Disease"},{"id":"343","span":{"begin":636,"end":671},"obj":"Disease"}],"attributes":[{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Tax:2697049"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"Tax:9606"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"MESH:D008550"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"MESH:D008550"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"MESH:C000657245"},{"id":"A336","pred":"tao:has_database_id","subj":"336","obj":"MESH:D007239"},{"id":"A337","pred":"tao:has_database_id","subj":"337","obj":"MESH:D006973"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"MESH:D012128"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"MESH:D007249"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"MESH:D012128"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"MESH:D055370"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"MESH:D012128"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:D012128"},{"subj":"331","pred":"source","obj":"LitCovid-PubTator"},{"subj":"332","pred":"source","obj":"LitCovid-PubTator"},{"subj":"333","pred":"source","obj":"LitCovid-PubTator"},{"subj":"334","pred":"source","obj":"LitCovid-PubTator"},{"subj":"335","pred":"source","obj":"LitCovid-PubTator"},{"subj":"336","pred":"source","obj":"LitCovid-PubTator"},{"subj":"337","pred":"source","obj":"LitCovid-PubTator"},{"subj":"338","pred":"source","obj":"LitCovid-PubTator"},{"subj":"339","pred":"source","obj":"LitCovid-PubTator"},{"subj":"340","pred":"source","obj":"LitCovid-PubTator"},{"subj":"341","pred":"source","obj":"LitCovid-PubTator"},{"subj":"342","pred":"source","obj":"LitCovid-PubTator"},{"subj":"343","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":62,"end":71},"obj":"Body_part"},{"id":"T79","span":{"begin":92,"end":97},"obj":"Body_part"},{"id":"T80","span":{"begin":265,"end":273},"obj":"Body_part"},{"id":"T81","span":{"begin":412,"end":421},"obj":"Body_part"},{"id":"T82","span":{"begin":482,"end":495},"obj":"Body_part"},{"id":"T83","span":{"begin":617,"end":621},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma74644"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma74644"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":482,"end":495},"obj":"Body_part"},{"id":"T22","span":{"begin":617,"end":621},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T103","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"T104","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"T105","span":{"begin":165,"end":177},"obj":"Disease"},{"id":"T106","span":{"begin":281,"end":284},"obj":"Disease"},{"id":"T107","span":{"begin":285,"end":289},"obj":"Disease"},{"id":"T108","span":{"begin":497,"end":509},"obj":"Disease"},{"id":"T109","span":{"begin":570,"end":573},"obj":"Disease"},{"id":"T110","span":{"begin":574,"end":578},"obj":"Disease"},{"id":"T111","span":{"begin":606,"end":609},"obj":"Disease"},{"id":"T112","span":{"begin":611,"end":628},"obj":"Disease"},{"id":"T114","span":{"begin":622,"end":628},"obj":"Disease"},{"id":"T115","span":{"begin":630,"end":634},"obj":"Disease"},{"id":"T116","span":{"begin":636,"end":671},"obj":"Disease"},{"id":"T117","span":{"begin":642,"end":671},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A113","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0015796"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T109","span":{"begin":92,"end":97},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T110","span":{"begin":126,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T111","span":{"begin":247,"end":257},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T112","span":{"begin":316,"end":317},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T113","span":{"begin":431,"end":432},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T114","span":{"begin":482,"end":495},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T115","span":{"begin":617,"end":621},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T116","span":{"begin":617,"end":621},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T109","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T63","span":{"begin":46,"end":54},"obj":"Chemical"},{"id":"T64","span":{"begin":62,"end":71},"obj":"Chemical"},{"id":"T65","span":{"begin":412,"end":421},"obj":"Chemical"},{"id":"T66","span":{"begin":441,"end":449},"obj":"Chemical"}],"attributes":[{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_16796"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_16796"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T38","span":{"begin":7,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T39","span":{"begin":139,"end":154},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T40","span":{"begin":165,"end":177},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T41","span":{"begin":468,"end":478},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T42","span":{"begin":497,"end":509},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T38","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T58","span":{"begin":0,"end":72},"obj":"Sentence"},{"id":"T59","span":{"begin":73,"end":280},"obj":"Sentence"},{"id":"T60","span":{"begin":281,"end":411},"obj":"Sentence"},{"id":"T61","span":{"begin":412,"end":605},"obj":"Sentence"},{"id":"T62","span":{"begin":606,"end":610},"obj":"Sentence"},{"id":"T63","span":{"begin":611,"end":635},"obj":"Sentence"},{"id":"T64","span":{"begin":636,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T47","span":{"begin":265,"end":279},"obj":"Phenotype"},{"id":"T48","span":{"begin":281,"end":284},"obj":"Phenotype"},{"id":"T49","span":{"begin":570,"end":573},"obj":"Phenotype"},{"id":"T50","span":{"begin":606,"end":609},"obj":"Phenotype"},{"id":"T51","span":{"begin":611,"end":628},"obj":"Phenotype"},{"id":"T52","span":{"begin":642,"end":662},"obj":"Phenotype"}],"attributes":[{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93bcec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d6ec93"},{"id":"LitCovid-PD-UBERON","color":"#e893ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecce"},{"id":"LitCovid-PD-CLO","color":"#ecb493"},{"id":"LitCovid-PD-CHEBI","color":"#9a93ec"},{"id":"LitCovid-PD-GO-BP","color":"#a5ec93"},{"id":"LitCovid-sentences","color":"#ec93bf"},{"id":"LitCovid-PD-HP","color":"#93d9ec"}]}]}}