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PMC:7102583 / 16873-18753 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
677 3-12 Chemical denotes Melatonin MESH:D008550
718 281-285 Gene denotes VEGF Gene:7422
719 446-450 Gene denotes VEGF Gene:7422
720 723-728 Gene denotes NLRP3 Gene:114548
721 1084-1088 Gene denotes TLR4 Gene:7099
722 526-534 Species denotes patients Tax:9606
723 944-952 Species denotes patients Tax:9606
724 1603-1611 Species denotes patients Tax:9606
725 1686-1694 Species denotes patients Tax:9606
726 1832-1840 Species denotes patients Tax:9606
727 408-417 Chemical denotes melatonin MESH:D008550
728 673-682 Chemical denotes melatonin MESH:D008550
729 757-766 Chemical denotes melatonin MESH:D008550
730 918-927 Chemical denotes melatonin MESH:D008550
731 1152-1161 Chemical denotes melatonin MESH:D008550
732 1440-1449 Chemical denotes melatonin MESH:D008550
733 1567-1576 Chemical denotes melatonin MESH:D008550
734 1664-1673 Chemical denotes melatonin MESH:D008550
735 157-169 Disease denotes inflammation MESH:D007249
736 304-309 Disease denotes edema MESH:D004487
737 516-524 Disease denotes COVID-19 MESH:C000657245
738 551-555 Disease denotes ARDS MESH:D012128
739 591-597 Disease denotes sepsis MESH:D018805
740 602-616 Disease denotes cardiac arrest MESH:D006323
741 702-714 Disease denotes septic shock MESH:D012772
742 804-810 Disease denotes sepsis MESH:D018805
743 819-831 Disease denotes renal injury MESH:D007674
744 833-854 Disease denotes septic cardiomyopathy MESH:D009202
745 859-871 Disease denotes liver injury MESH:D017093
746 958-979 Disease denotes myocardial infarction MESH:D009203
747 981-995 Disease denotes cardiomyopathy MESH:D009202
748 997-1024 Disease denotes hypertensive heart diseases MESH:D006973
749 1029-1051 Disease denotes pulmonary hypertension MESH:D006976
750 1241-1255 Disease denotes cerebral edema MESH:D001929
751 1406-1415 Disease denotes mortality MESH:D003643
752 1492-1496 Disease denotes pain MESH:D010146
753 1498-1507 Disease denotes agitation MESH:D011595
754 1509-1516 Disease denotes anxiety MESH:D001007
755 1677-1685 Disease denotes COVID-19 MESH:C000657245
756 1738-1747 Disease denotes infection MESH:D007239
757 1756-1777 Disease denotes respiratory disorders MESH:D012131

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T184 3-12 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T185 213-229 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T186 225-229 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T187 346-351 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T188 357-370 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T189 357-362 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T190 408-417 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T191 463-480 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T192 475-480 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T193 673-682 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T194 757-766 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T195 859-864 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T196 918-927 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T197 1010-1015 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T198 1152-1161 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T199 1260-1265 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T200 1266-1271 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T201 1440-1449 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T202 1567-1576 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T203 1664-1673 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T43 357-370 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T44 357-362 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T45 363-370 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T46 859-864 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T47 1010-1015 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T48 1260-1265 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T49 1266-1271 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51344s15 252-262 PosReg denotes increasing
p51344s17 267-277 MPA denotes production
p51344s26 318-331 MPA denotes extravasation

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T177 157-169 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T178 516-524 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 547-550 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T180 551-555 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T181 602-616 Disease denotes cardiac arrest http://purl.obolibrary.org/obo/MONDO_0000745
T182 825-831 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T183 840-854 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T184 865-871 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T185 958-979 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T186 981-995 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T187 997-1024 Disease denotes hypertensive heart diseases http://purl.obolibrary.org/obo/MONDO_0001302
T188 1029-1051 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T189 1039-1051 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T190 1509-1516 Disease denotes anxiety http://purl.obolibrary.org/obo/MONDO_0005618|http://purl.obolibrary.org/obo/MONDO_0011918
T192 1677-1685 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T193 1738-1747 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T194 1756-1777 Disease denotes respiratory disorders http://purl.obolibrary.org/obo/MONDO_0005087

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T223 198-208 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T224 213-229 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T225 346-351 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T226 357-370 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T227 357-370 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T228 463-480 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T229 771-772 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 859-864 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T231 859-864 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T232 1010-1015 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T233 1010-1015 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T234 1010-1015 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T235 1010-1015 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T236 1098-1108 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T237 1260-1265 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T238 1260-1265 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T239 1266-1271 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T240 1266-1271 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T241 1299-1300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 1532-1533 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 1624-1626 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T244 1704-1711 http://purl.obolibrary.org/obo/CLO_0009985 denotes focuses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T172 3-12 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T173 32-40 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T174 408-417 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T175 658-669 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T176 673-682 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T177 757-766 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T178 918-927 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T179 1152-1161 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T180 1425-1436 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T181 1440-1449 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T182 1567-1576 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T183 1664-1673 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T74 157-169 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T75 174-190 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T76 213-239 http://purl.obolibrary.org/obo/GO_0072577 denotes endothelial cell apoptosis
T77 230-239 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T78 230-239 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T79 1218-1239 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T80 1586-1591 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T113 0-48 Sentence denotes 7 Melatonin & other supportive adjuvant effects
T114 49-149 Sentence denotes The integrity of the vascular endothelial barrier is crucial in the immunoregulation within alveoli.
T115 150-371 Sentence denotes Severe inflammation and immune responses induce epithelial and endothelial cell apoptosis, as well as increasing the production of VEGF, which aggravates edema and the extravasation of the immune cells from blood vessels.
T116 372-486 Sentence denotes Experimental evidence suggests that melatonin mediates the suppression of VEGF in vascular endothelial cells [62].
T117 487-621 Sentence denotes Based on clinical reports of COVID-19, patients with severe ALI/ARDS may also have an increased risk of sepsis and cardiac arrest [2].
T118 622-742 Sentence denotes Published reports indicate that the application of melatonin may ameliorate the septic shock via the NLRP3 pathway [63].
T119 743-891 Sentence denotes Specifically, melatonin may a have preventive effect against sepsis-induced renal injury, septic cardiomyopathy and liver injury [[64], [65], [66]].
T120 892-1141 Sentence denotes It was also reported that melatonin had benefits in patients with myocardial infarction, cardiomyopathy, hypertensive heart diseases and pulmonary hypertension, and probably functions via the TLR4/survivor activating factor enhancement pathway [67].
T121 1142-1340 Sentence denotes Moreover, melatonin exerts neurological protection by reducing the cerebral inflammatory response, cerebral edema and brain-blood barrier permeability under a number of experimental conditions [68].
T122 1341-1525 Sentence denotes In the ICU, deep sedation is associated with increased long-term mortality, and the application of melatonin reduces sedation use and the frequency of pain, agitation, anxiety [69,70].
T123 1526-1628 Sentence denotes Also, a recent meta-analysis showed that melatonin improves sleep quality in patients in the ICU [71].
T124 1629-1880 Sentence denotes Thus, the rationale for the use of melatonin in COVID-19 patients not only focuses on the attenuation of the infection-induced respiratory disorders, but also on an overall improvement and prevention of patients' wellbeing and potential complications.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T77 304-309 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969
T78 547-550 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T79 591-597 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T80 602-616 Phenotype denotes cardiac arrest http://purl.obolibrary.org/obo/HP_0001695
T81 709-714 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T82 804-810 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T83 840-854 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T84 958-979 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T85 981-995 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T86 1039-1051 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T87 1241-1255 Phenotype denotes cerebral edema http://purl.obolibrary.org/obo/HP_0002181
T88 1492-1496 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T89 1498-1507 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713
T90 1509-1516 Phenotype denotes anxiety http://purl.obolibrary.org/obo/HP_0000739

2_test

Id Subject Object Predicate Lexical cue
32217117-30569127-66453519 482-484 30569127 denotes 62
32217117-26681113-66453520 738-740 26681113 denotes 63
32217117-31432108-66453521 874-876 31432108 denotes 64
32217117-31535369-66453522 880-882 31535369 denotes 65
32217117-31234024-66453523 886-888 31234024 denotes 66
32217117-26465095-66453524 1137-1139 26465095 denotes 67
32217117-28503116-66453525 1336-1338 28503116 denotes 68
32217117-32074506-66453526 1518-1520 32074506 denotes 69
32217117-25969139-66453527 1521-1523 25969139 denotes 70
32217117-29746721-66453528 1624-1626 29746721 denotes 71