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PMC:7102583 / 11345-13131 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
477 3-12 Chemical denotes Melatonin MESH:D008550
510 567-571 Gene denotes IL-6 Gene:3569
511 597-617 Gene denotes Toll-like receptor 4 Gene:7099
512 619-623 Gene denotes TLR4 Gene:7099
513 671-675 Gene denotes TLR4 Gene:7099
514 889-893 Gene denotes TLR4 Gene:7099
515 1070-1078 Species denotes patients Tax:9606
516 1127-1135 Species denotes patients Tax:9606
517 1511-1518 Species denotes infants Tax:9606
518 59-68 Chemical denotes melatonin MESH:D008550
519 228-240 Chemical denotes nitric oxide MESH:D009569
520 291-304 Chemical denotes free radicals MESH:D005609
521 321-333 Chemical denotes free radical MESH:D005609
522 760-769 Chemical denotes melatonin MESH:D008550
523 834-843 Chemical denotes melatonin MESH:D008550
524 953-962 Chemical denotes melatonin MESH:D008550
525 1242-1248 Chemical denotes oxygen MESH:D010100
526 1484-1493 Chemical denotes melatonin MESH:D008550
527 1611-1620 Chemical denotes melatonin MESH:D008550
528 1677-1686 Chemical denotes melatonin MESH:D008550
529 351-367 Disease denotes Viral infections MESH:D001102
530 774-788 Disease denotes brain ischemia MESH:D002545
531 790-825 Disease denotes gastritis and periodontitis disease MESH:D010510
532 864-876 Disease denotes inflammation MESH:D007249
533 1015-1021 Disease denotes sepsis MESH:D018805
534 1026-1034 Disease denotes ischemia MESH:D007511
535 1065-1069 Disease denotes ARDS MESH:D012128
536 1181-1193 Disease denotes inflammation MESH:D007249
537 1195-1204 Disease denotes hypoxemia MESH:D000860
538 1418-1426 Disease denotes COVID-19 MESH:C000657245
539 1524-1544 Disease denotes respiratory distress MESH:D012128
540 1726-1738 Disease denotes inflammation MESH:D007249
541 1756-1776 Disease denotes coronavirus infected MESH:D018352

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T111 3-12 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T112 59-68 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T113 485-508 Body_part denotes low density lipoprotein http://purl.org/sig/ont/fma/fma63170
T114 572-592 Body_part denotes alveolar macrophages http://purl.org/sig/ont/fma/fma83023
T115 705-718 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T116 760-769 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T117 774-779 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T118 834-843 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T119 953-962 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T120 1484-1493 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T121 1611-1620 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T122 1628-1632 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T123 1677-1686 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T27 705-718 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T28 774-779 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T29 1628-1632 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51310s37 1285-1303 MPA denotes oxidant generation

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T131 351-367 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T132 434-438 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T133 447-450 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T134 661-664 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T135 774-788 Disease denotes brain ischemia http://purl.obolibrary.org/obo/MONDO_0005299
T136 780-788 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T137 790-799 Disease denotes gastritis http://purl.obolibrary.org/obo/MONDO_0004966
T138 804-825 Disease denotes periodontitis disease http://purl.obolibrary.org/obo/MONDO_0002635
T139 804-817 Disease denotes periodontitis http://purl.obolibrary.org/obo/MONDO_0005076
T140 864-876 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T141 990-993 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T142 1026-1034 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T143 1061-1064 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T144 1065-1069 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T145 1181-1193 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T146 1418-1426 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T147 1726-1738 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T137 432-433 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 509-518 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T139 628-630 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T140 628-630 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T141 631-640 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T142 666-668 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T143 679-680 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 705-718 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T145 735-736 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 774-779 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T147 774-779 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T148 844-847 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T149 894-903 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T150 963-966 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T151 1546-1549 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T152 1628-1632 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T153 1628-1632 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T112 3-12 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T113 59-68 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T114 161-171 Chemical denotes superoxide http://purl.obolibrary.org/obo/CHEBI_18421
T115 228-240 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T116 235-240 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T118 296-304 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T119 321-343 Chemical denotes free radical scavenger http://purl.obolibrary.org/obo/CHEBI_48578
T120 321-333 Chemical denotes free radical http://purl.obolibrary.org/obo/CHEBI_26519
T121 476-508 Chemical denotes oxidized low density lipoprotein http://purl.obolibrary.org/obo/CHEBI_60151
T122 497-508 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T123 567-569 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T125 625-627 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T128 760-769 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T129 834-843 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T130 953-962 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T131 1242-1248 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T132 1285-1292 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T133 1484-1493 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T134 1570-1577 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T135 1611-1620 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T136 1662-1673 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T137 1677-1686 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T48 351-367 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T49 509-541 http://purl.obolibrary.org/obo/GO_0002218 denotes activates innate immune response
T50 519-541 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T51 526-541 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T52 631-640 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T53 698-711 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T54 864-876 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T55 894-903 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 1181-1193 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T57 1726-1738 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T80 0-29 Sentence denotes 4 Melatonin & anti-oxidation
T81 30-350 Sentence denotes The anti-oxidative effect of melatonin cooperates with its anti-inflammatory actions by up-regulating anti-oxidative enzymes (e.g. superoxide dismutase), down-regulating pro-oxidative enzymes (e.g. nitric oxide synthase), and it may also interact directly with free radicals, functioning as free radical scavenger [3,4].
T82 351-428 Sentence denotes Viral infections and their replication constantly generate oxidized products.
T83 429-670 Sentence denotes In a SARS-induced ALI model, the production of oxidized low density lipoprotein activates innate immune response by the overproduction of IL-6 alveolar macrophages via Toll-like receptor 4 (TLR4)/NF-kB signaling, thereby leading to ALI [36].
T84 671-770 Sentence denotes TLR4 is a receptor for the innate immune system, and it is also a therapeutic target for melatonin.
T85 771-923 Sentence denotes In brain ischemia, gastritis and periodontitis disease models, melatonin has documented anti-inflammation actions via TLR4 signaling [[37], [38], [39]].
T86 924-1057 Sentence denotes The anti-oxidative effect of melatonin has also been confirmed in ALI caused by radiation, sepsis and ischemia-reperfusion [4,40,41].
T87 1058-1339 Sentence denotes In ALI/ARDS patients, especially when the disease is advanced and in patients treated in intense care units (ICUs), severe inflammation, hypoxemia and mechanical ventilation with high oxygen concentrations inevitably increases oxidant generation locally and systematically [42,43].
T88 1340-1427 Sentence denotes Accordingly, we speculate that excessive oxidation also is likely involved in COVID-19.
T89 1428-1633 Sentence denotes The extensive studies of Gitto et al. [44,45], who used melatonin to treat newborn infants with respiratory distress, has documented the anti-oxidant and anti-inflammatory actions of melatonin in the lung.
T90 1634-1786 Sentence denotes Thus, it is likely that the application of melatonin would be beneficial in controlling the inflammation and oxidation in coronavirus infected subjects.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T59 447-450 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T60 661-664 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T61 774-788 Phenotype denotes brain ischemia http://purl.obolibrary.org/obo/HP_0002637
T62 790-799 Phenotype denotes gastritis http://purl.obolibrary.org/obo/HP_0005263
T63 804-817 Phenotype denotes periodontitis http://purl.obolibrary.org/obo/HP_0000704
T64 990-993 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T65 1015-1021 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T66 1061-1064 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T67 1195-1204 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T68 1524-1544 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

2_test

Id Subject Object Predicate Lexical cue
32217117-18423196-66453497 666-668 18423196 denotes 36
32217117-31158461-66453498 906-908 31158461 denotes 37
32217117-30173051-66453499 912-914 30173051 denotes 38
32217117-25360211-66453500 1050-1052 25360211 denotes 40
32217117-23733646-66453501 1335-1337 23733646 denotes 43
32217117-16150110-66453502 1467-1469 16150110 denotes 44
32217117-15168319-66453503 1470-1472 15168319 denotes 45