PMC:7102556 / 17196-18672
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 315 | 78-82 | Species | denotes | CoVs | Tax:11118 |
| 316 | 511-516 | Species | denotes | human | Tax:9606 |
| 317 | 623-627 | Species | denotes | mice | Tax:10090 |
| 318 | 752-767 | Species | denotes | transgenic mice | Tax:10090 |
| 319 | 804-809 | Species | denotes | human | Tax:9606 |
| 320 | 896-901 | Species | denotes | human | Tax:9606 |
| 321 | 1131-1139 | Species | denotes | SARS-CoV | Tax:694009 |
| 322 | 1461-1467 | Species | denotes | humans | Tax:9606 |
| 323 | 703-708 | Species | denotes | mouse | Tax:10090 |
| 324 | 998-1003 | Species | denotes | human | Tax:9606 |
| 325 | 1149-1167 | Disease | denotes | MERS-CoV infection | MESH:D018352 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T88 | 64-71 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T89 | 131-138 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T90 | 219-229 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T91 | 689-696 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T92 | 885-890 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T93 | 956-964 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T94 | 1382-1389 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p50311s20 | 193-196 | MPA | denotes | off |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T67 | 303-306 | Disease | denotes | ADE | http://purl.obolibrary.org/obo/MONDO_0019383 |
| T68 | 1131-1139 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T69 | 1158-1167 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T190 | 72-74 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T191 | 72-74 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T192 | 128-130 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T193 | 140-142 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T194 | 140-142 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T195 | 509-510 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T196 | 511-516 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T197 | 531-540 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humanized |
| T198 | 703-708 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T199 | 725-734 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humanized |
| T200 | 804-809 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T201 | 883-890 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T202 | 896-901 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T203 | 998-1003 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T204 | 1261-1262 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T205 | 1375-1376 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T206 | 1461-1467 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T112 | 64-71 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T113 | 72-74 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T114 | 131-138 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T115 | 140-142 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T116 | 219-229 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T117 | 219-224 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T118 | 225-229 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T119 | 689-696 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T120 | 1382-1389 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T107 | 0-83 | Sentence | denotes | So far, most neutralizing antibodies recognize the RBD in the S protein S2 of CoVs. |
| T108 | 84-312 | Sentence | denotes | Compared with the high mutation rate in the S1 protein, S2 is much more conservative, thereby decreasing the off-target risk caused by amino acid replacement [62], and also bypassing the special epitopes that may cause ADE [63]. |
| T109 | 313-458 | Sentence | denotes | This means that the cocktail of monoclonal antibodies binding to different epitopes of RBD would be more desirable for therapeutic purposes [64]. |
| T110 | 459-599 | Sentence | denotes | For treatment, the monoclonal antibodies are from a human source or are humanized antibodies, isolated or generated with various approaches. |
| T111 | 600-697 | Sentence | denotes | For example, wild-type mice were immunized with soluble recombinant RBD containing the S protein. |
| T112 | 698-848 | Sentence | denotes | Then mouse antibodies were humanized and isolated, or transgenic mice were directly immunized, to express human versions of the antibodies [50,65,66]. |
| T113 | 849-1015 | Sentence | denotes | However, direct cloning of single B cells from human survivors, used in combination with the phage-display antibody library, could provide authentic human antibodies. |
| T114 | 1016-1179 | Sentence | denotes | Until now, it should be noted that many neutralizing antibodies have been successfully discovered for treatment of SARS-CoV [67] and MERS-CoV infection [45,68,69]. |
| T115 | 1180-1260 | Sentence | denotes | These antibodies have all been described favorably in the literature [29,70,71]. |
| T116 | 1261-1476 | Sentence | denotes | A similar approach is known as single chain fragment variable (scFv) library screening, whereby the use of RBD as a bait protein allows some neutralizing antibodies to be screened out from non-immune humans [72,73]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32017984-15210961-69697770 | 243-245 | 15210961 | denotes | 62 |
| 32017984-7682252-69697771 | 308-310 | 7682252 | denotes | 63 |
| 32017984-15994800-69697772 | 454-456 | 15994800 | denotes | 64 |
| 32017984-15814718-69697773 | 838-840 | 15814718 | denotes | 50 |
| 32017984-27312105-69697774 | 841-843 | 27312105 | denotes | 65 |
| 32017984-26124093-69697775 | 844-846 | 26124093 | denotes | 66 |
| 32017984-15247913-69697776 | 1141-1143 | 15247913 | denotes | 67 |
| 32017984-29514901-69697777 | 1169-1171 | 29514901 | denotes | 45 |
| 32017984-26216974-69697778 | 1172-1174 | 26216974 | denotes | 68 |
| 32017984-28472421-69697779 | 1175-1177 | 28472421 | denotes | 69 |
| 32017984-30646569-69697780 | 1250-1252 | 30646569 | denotes | 29 |
| 32017984-21905149-69697781 | 1256-1258 | 21905149 | denotes | 71 |
| 32017984-24778221-69697782 | 1469-1471 | 24778221 | denotes | 72 |
| 32017984-18989460-69697783 | 1472-1474 | 18989460 | denotes | 73 |