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PMC:7102553 / 74-1409 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
7 38-55 Species denotes novel coronavirus Tax:2697049
8 164-177 Species denotes coronaviruses Tax:11118
9 57-65 Disease denotes COVID-19 MESH:C000657245
15 347-352 Gene denotes GRP78 Gene:3309
16 317-324 Chemical denotes Glucose MESH:D005947
17 259-267 Disease denotes COVID-19 MESH:C000657245
18 445-453 Disease denotes COVID-19 MESH:C000657245
19 506-510 Disease denotes SARS MESH:D045169
24 787-792 Gene denotes GRP78 Gene:3309
25 885-890 Gene denotes GRP78 Gene:3309
26 930-941 Species denotes coronavirus Tax:11118
27 673-685 Chemical denotes cyclic Pep42
31 1138-1143 Gene denotes GRP78 Gene:3309
32 1185-1190 Gene denotes GRP78 Gene:3309
33 1326-1334 Disease denotes COVID-19 MESH:C000657245

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 317-324 https://glytoucan.org/Structures/Glycans/G15021LG denotes Glucose

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 80-84 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T3 153-160 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 213-217 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 294-306 Body_part denotes cell-surface http://purl.org/sig/ont/fma/fma67653
T6 294-298 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T7 317-324 Body_part denotes Glucose http://purl.org/sig/ont/fma/fma82743
T8 335-342 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T9 460-467 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 687-694 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T11 695-702 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T12 948-955 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 983-987 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 1120-1127 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 57-65 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 259-267 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 445-453 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 506-510 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T6 1326-1334 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T2 9-19 http://purl.obolibrary.org/obo/BFO_0000030 denotes Objectives
T3 80-84 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 213-217 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 294-298 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 728-732 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T7 983-987 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 153-160 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 317-324 Chemical denotes Glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_42758
T5 335-342 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T6 460-467 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7 687-694 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T8 695-702 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 948-955 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 1092-1094 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T11 1120-1127 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 1152-1154 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 80-96 http://purl.obolibrary.org/obo/GO_0008037 denotes cell recognition
T2 213-229 http://purl.obolibrary.org/obo/GO_0008037 denotes cell recognition
T3 959-982 http://purl.obolibrary.org/obo/GO_0044405 denotes recognition of the host

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-7 Sentence denotes Summary
T4 9-19 Sentence denotes Objectives
T5 20-142 Sentence denotes Understanding the novel coronavirus (COVID-19) mode of host cell recognition may help to fight the disease and save lives.
T6 143-230 Sentence denotes The spike protein of coronaviruses is the main driving force for host cell recognition.
T7 232-239 Sentence denotes Methods
T8 240-440 Sentence denotes In this study, the COVID-19 spike binding site to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78)) is predicted using combined molecular modeling docking and structural bioinformatics.
T9 441-517 Sentence denotes The COVID-19 spike protein is modeled using its counterpart, the SARS spike.
T10 519-526 Sentence denotes Results
T11 527-686 Sentence denotes Sequence and structural alignments show that four regions, in addition to its cyclic nature have sequence and physicochemical similarities to the cyclic Pep42.
T12 687-827 Sentence denotes Protein-protein docking was performed to test the four regions of the spike that fit tightly in the GRP78 Substrate Binding Domain β (SBDβ).
T13 828-997 Sentence denotes The docking pose revealed the involvement of the SBDβ of GRP78 and the receptor-binding domain of the coronavirus spike protein in recognition of the host cell receptor.
T14 999-1010 Sentence denotes Conclusions
T15 1011-1144 Sentence denotes We reveal that the binding is more favorable between regions III (C391-C525) and IV (C480-C488) of the spike protein model and GRP78.
T16 1145-1252 Sentence denotes Region IV is the main driving force for GRP78 binding with the predicted binding affinity of -9.8 kcal/mol.
T17 1253-1335 Sentence denotes These nine residues can be used to develop therapeutics specific against COVID-19.