PMC:7102551 / 3548-4206 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T124","span":{"begin":38,"end":42},"obj":"GO:0051716"},{"id":"T123","span":{"begin":55,"end":65},"obj":"SP_7"},{"id":"T122","span":{"begin":232,"end":240},"obj":"SP_10"},{"id":"T121","span":{"begin":273,"end":278},"obj":"NCBITaxon:10088"},{"id":"T120","span":{"begin":346,"end":350},"obj":"UBERON:0002048"},{"id":"T119","span":{"begin":389,"end":400},"obj":"UBERON:0001004"},{"id":"T118","span":{"begin":415,"end":426},"obj":"UBERON:0001004"},{"id":"T117","span":{"begin":543,"end":551},"obj":"SP_7"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":346,"end":350},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":346,"end":350},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T33","span":{"begin":55,"end":63},"obj":"Disease"},{"id":"T34","span":{"begin":55,"end":59},"obj":"Disease"},{"id":"T35","span":{"begin":66,"end":75},"obj":"Disease"},{"id":"T36","span":{"begin":121,"end":124},"obj":"Disease"},{"id":"T37","span":{"begin":232,"end":240},"obj":"Disease"},{"id":"T38","span":{"begin":232,"end":236},"obj":"Disease"},{"id":"T39","span":{"begin":292,"end":295},"obj":"Disease"},{"id":"T40","span":{"begin":326,"end":338},"obj":"Disease"},{"id":"T41","span":{"begin":401,"end":407},"obj":"Disease"},{"id":"T42","span":{"begin":409,"end":444},"obj":"Disease"},{"id":"T43","span":{"begin":415,"end":444},"obj":"Disease"},{"id":"T44","span":{"begin":465,"end":477},"obj":"Disease"},{"id":"T45","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T46","span":{"begin":574,"end":577},"obj":"Disease"}],"attributes":[{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24","span":{"begin":76,"end":79},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T25","span":{"begin":185,"end":186},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":265,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T27","span":{"begin":273,"end":278},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T28","span":{"begin":346,"end":350},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T29","span":{"begin":346,"end":350},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T30","span":{"begin":585,"end":586},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":326,"end":338},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T8","span":{"begin":465,"end":477},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-sentences","denotations":[{"id":"T28","span":{"begin":0,"end":199},"obj":"Sentence"},{"id":"T29","span":{"begin":200,"end":365},"obj":"Sentence"},{"id":"T30","span":{"begin":366,"end":560},"obj":"Sentence"},{"id":"T31","span":{"begin":561,"end":658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":415,"end":435},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}

{"project":"LitCovid-PubTator","denotations":[{"id":"88","span":{"begin":232,"end":240},"obj":"Species"},{"id":"89","span":{"begin":273,"end":278},"obj":"Species"},{"id":"90","span":{"begin":55,"end":75},"obj":"Disease"},{"id":"91","span":{"begin":326,"end":338},"obj":"Disease"},{"id":"92","span":{"begin":389,"end":407},"obj":"Disease"},{"id":"93","span":{"begin":409,"end":444},"obj":"Disease"},{"id":"94","span":{"begin":465,"end":477},"obj":"Disease"},{"id":"95","span":{"begin":543,"end":551},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Tax:694009"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:10090"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"MESH:C000657245"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"MESH:D007249"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"MESH:D012131"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"MESH:D012128"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"MESH:D007249"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While the molecular and immunological host response to SARS-CoV-2 infection has not yet been fully elucidated to confirm ADE is occuring, the current clinical evidence suggests this is a possibility. Based on previous studies using SARS-CoV using in vitro studies [11] and mouse models [12], ADE hinders the ability to manage inflammation in the lung and elsewhere. This may lead to acute respiratory injury, acute respiratory distress syndrome, and other observed inflammation-based sequelae as seen in many of the documented cases of severe COVID-19 disease. In addition, ADE offers a viable explanation for the geographic discrepancy in severity of cases."}