PMC:7100515 / 41284-41721 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T362","span":{"begin":14,"end":19},"obj":"Body_part"},{"id":"T363","span":{"begin":71,"end":79},"obj":"Body_part"}],"attributes":[{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma67180"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T907","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T908","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T909","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T910","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T911","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T912","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T913","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T914","span":{"begin":14,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T915","span":{"begin":126,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T916","span":{"begin":277,"end":278},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T357","span":{"begin":94,"end":103},"obj":"Chemical"},{"id":"T358","span":{"begin":104,"end":109},"obj":"Chemical"},{"id":"T359","span":{"begin":137,"end":146},"obj":"Chemical"},{"id":"T360","span":{"begin":170,"end":193},"obj":"Chemical"},{"id":"T361","span":{"begin":170,"end":177},"obj":"Chemical"},{"id":"T363","span":{"begin":220,"end":230},"obj":"Chemical"},{"id":"T364","span":{"begin":232,"end":253},"obj":"Chemical"},{"id":"T365","span":{"begin":244,"end":253},"obj":"Chemical"},{"id":"T366","span":{"begin":267,"end":288},"obj":"Chemical"},{"id":"T367","span":{"begin":279,"end":288},"obj":"Chemical"},{"id":"T368","span":{"begin":311,"end":320},"obj":"Chemical"},{"id":"T369","span":{"begin":404,"end":413},"obj":"Chemical"}],"attributes":[{"id":"A357","pred":"chebi_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A358","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_31206"},{"id":"A359","pred":"chebi_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A360","pred":"chebi_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/CHEBI_38215"},{"id":"A361","pred":"chebi_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A362","pred":"chebi_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A363","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A364","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_70821"},{"id":"A365","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A366","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_64932"},{"id":"A367","pred":"chebi_id","subj":"T367","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A368","pred":"chebi_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A369","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T80","span":{"begin":80,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0045851"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}

{"project":"LitCovid-sentences","denotations":[{"id":"T294","span":{"begin":0,"end":437},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1654","span":{"begin":8,"end":13},"obj":"Gene"},{"id":"1655","span":{"begin":232,"end":243},"obj":"Gene"},{"id":"1656","span":{"begin":267,"end":278},"obj":"Gene"},{"id":"1657","span":{"begin":0,"end":7},"obj":"CellLine"}],"attributes":[{"id":"A1654","pred":"tao:has_database_id","subj":"1654","obj":"Gene:59272"},{"id":"A1655","pred":"tao:has_database_id","subj":"1655","obj":"Gene:1514"},{"id":"A1656","pred":"tao:has_database_id","subj":"1656","obj":"Gene:1508"},{"id":"A1657","pred":"tao:has_database_id","subj":"1657","obj":"CVCL:0045"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"HEK 293/hACE2 cells were pretreated with either lysosomotropic agents (endosome acidification inhibitor NH4Cl and bafilomycin A; PIKfyve inhibitor apilimod and YM201636; calcium channel blocker tetrandrine) or cathepsin inhibitors (cathepsin L inhibitor SID26881509, cathepsin B inhibitor CA-074, and cathepsin inhibitor E64D) for 1 h at 37 °C, then spin-inoculated with pseudovirions in the presence of inhibitor at 1200 × g for 30 min."}