PMC:7100515 / 36118-37386 JSONTXT

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Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

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embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T288","span":{"begin":80,"end":87},"obj":"Chemical"},{"id":"T289","span":{"begin":195,"end":198},"obj":"Chemical"},{"id":"T290","span":{"begin":255,"end":258},"obj":"Chemical"},{"id":"T291","span":{"begin":337,"end":340},"obj":"Chemical"},{"id":"T292","span":{"begin":391,"end":394},"obj":"Chemical"},{"id":"T293","span":{"begin":433,"end":435},"obj":"Chemical"},{"id":"T294","span":{"begin":617,"end":619},"obj":"Chemical"},{"id":"T295","span":{"begin":1066,"end":1076},"obj":"Chemical"},{"id":"T297","span":{"begin":1085,"end":1097},"obj":"Chemical"},{"id":"T299","span":{"begin":1195,"end":1198},"obj":"Chemical"}],"attributes":[{"id":"A288","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A289","pred":"chebi_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A292","pred":"chebi_id","subj":"T292","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_75008"},{"id":"A294","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_73819"},{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_17334"},{"id":"A296","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_51356"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_17076"},{"id":"A298","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_58007"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T76","span":{"begin":638,"end":647},"obj":"http://purl.obolibrary.org/obo/GO_0007565"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":365,"end":374},"obj":"Phenotype"},{"id":"T7","span":{"begin":449,"end":458},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0030731"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0030731"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":78,"end":87},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0020"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-sentences","denotations":[{"id":"T263","span":{"begin":0,"end":442},"obj":"Sentence"},{"id":"T264","span":{"begin":443,"end":588},"obj":"Sentence"},{"id":"T265","span":{"begin":589,"end":685},"obj":"Sentence"},{"id":"T266","span":{"begin":686,"end":968},"obj":"Sentence"},{"id":"T267","span":{"begin":969,"end":1152},"obj":"Sentence"},{"id":"T268","span":{"begin":1153,"end":1268},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1508","span":{"begin":391,"end":396},"obj":"Gene"},{"id":"1509","span":{"begin":736,"end":740},"obj":"Gene"},{"id":"1510","span":{"begin":746,"end":751},"obj":"Gene"},{"id":"1511","span":{"begin":822,"end":825},"obj":"Gene"},{"id":"1512","span":{"begin":831,"end":835},"obj":"Gene"},{"id":"1513","span":{"begin":885,"end":889},"obj":"Gene"},{"id":"1514","span":{"begin":896,"end":901},"obj":"Gene"},{"id":"1515","span":{"begin":1125,"end":1128},"obj":"Gene"},{"id":"1516","span":{"begin":1195,"end":1200},"obj":"Gene"},{"id":"1517","span":{"begin":1264,"end":1267},"obj":"Gene"},{"id":"1518","span":{"begin":0,"end":5},"obj":"Species"},{"id":"1519","span":{"begin":101,"end":106},"obj":"Species"},{"id":"1520","span":{"begin":152,"end":157},"obj":"Species"},{"id":"1521","span":{"begin":205,"end":210},"obj":"Species"},{"id":"1522","span":{"begin":265,"end":285},"obj":"Species"},{"id":"1523","span":{"begin":350,"end":355},"obj":"Species"},{"id":"1524","span":{"begin":443,"end":448},"obj":"Species"},{"id":"1525","span":{"begin":661,"end":680},"obj":"Species"},{"id":"1526","span":{"begin":730,"end":735},"obj":"Species"},{"id":"1527","span":{"begin":759,"end":766},"obj":"Species"},{"id":"1528","span":{"begin":816,"end":821},"obj":"Species"},{"id":"1529","span":{"begin":879,"end":884},"obj":"Species"},{"id":"1530","span":{"begin":1153,"end":1167},"obj":"Species"},{"id":"1531","span":{"begin":1004,"end":1018},"obj":"Chemical"},{"id":"1532","span":{"begin":1066,"end":1076},"obj":"Chemical"},{"id":"1533","span":{"begin":1085,"end":1097},"obj":"Chemical"},{"id":"1534","span":{"begin":1111,"end":1120},"obj":"Chemical"},{"id":"1535","span":{"begin":1230,"end":1238},"obj":"Chemical"},{"id":"1536","span":{"begin":6,"end":22},"obj":"Disease"},{"id":"1537","span":{"begin":356,"end":374},"obj":"Disease"},{"id":"1538","span":{"begin":449,"end":458},"obj":"Disease"},{"id":"1539","span":{"begin":53,"end":57},"obj":"CellLine"},{"id":"1540","span":{"begin":188,"end":192},"obj":"CellLine"},{"id":"1541","span":{"begin":248,"end":252},"obj":"CellLine"},{"id":"1542","span":{"begin":308,"end":310},"obj":"CellLine"},{"id":"1543","span":{"begin":385,"end":389},"obj":"CellLine"},{"id":"1544","span":{"begin":493,"end":497},"obj":"CellLine"},{"id":"1545","span":{"begin":686,"end":693},"obj":"CellLine"},{"id":"1546","span":{"begin":838,"end":842},"obj":"CellLine"},{"id":"1547","span":{"begin":891,"end":895},"obj":"CellLine"}],"attributes":[{"id":"A1508","pred":"tao:has_database_id","subj":"1508","obj":"Gene:6347"},{"id":"A1509","pred":"tao:has_database_id","subj":"1509","obj":"Gene:59272"},{"id":"A1510","pred":"tao:has_database_id","subj":"1510","obj":"Gene:59272"},{"id":"A1511","pred":"tao:has_database_id","subj":"1511","obj":"Gene:290"},{"id":"A1512","pred":"tao:has_database_id","subj":"1512","obj":"Gene:290"},{"id":"A1513","pred":"tao:has_database_id","subj":"1513","obj":"Gene:1803"},{"id":"A1514","pred":"tao:has_database_id","subj":"1514","obj":"Gene:1803"},{"id":"A1515","pred":"tao:has_database_id","subj":"1515","obj":"Gene:3490"},{"id":"A1516","pred":"tao:has_database_id","subj":"1516","obj":"Gene:714751"},{"id":"A1517","pred":"tao:has_database_id","subj":"1517","obj":"Gene:3490"},{"id":"A1518","pred":"tao:has_database_id","subj":"1518","obj":"Tax:9606"},{"id":"A1519","pred":"tao:has_database_id","subj":"1519","obj":"Tax:9606"},{"id":"A1520","pred":"tao:has_database_id","subj":"1520","obj":"Tax:9606"},{"id":"A1521","pred":"tao:has_database_id","subj":"1521","obj":"Tax:9606"},{"id":"A1522","pred":"tao:has_database_id","subj":"1522","obj":"Tax:9534"},{"id":"A1523","pred":"tao:has_database_id","subj":"1523","obj":"Tax:9606"},{"id":"A1524","pred":"tao:has_database_id","subj":"1524","obj":"Tax:9606"},{"id":"A1525","pred":"tao:has_database_id","subj":"1525","obj":"Tax:89399"},{"id":"A1526","pred":"tao:has_database_id","subj":"1526","obj":"Tax:9606"},{"id":"A1527","pred":"tao:has_database_id","subj":"1527","obj":"Tax:10034"},{"id":"A1528","pred":"tao:has_database_id","subj":"1528","obj":"Tax:9606"},{"id":"A1529","pred":"tao:has_database_id","subj":"1529","obj":"Tax:9606"},{"id":"A1530","pred":"tao:has_database_id","subj":"1530","obj":"Tax:9544"},{"id":"A1532","pred":"tao:has_database_id","subj":"1532","obj":"MESH:D010406"},{"id":"A1533","pred":"tao:has_database_id","subj":"1533","obj":"MESH:D013307"},{"id":"A1534","pred":"tao:has_database_id","subj":"1534","obj":"MESH:D000666"},{"id":"A1536","pred":"tao:has_database_id","subj":"1536","obj":"MESH:D007674"},{"id":"A1537","pred":"tao:has_database_id","subj":"1537","obj":"MESH:D002583"},{"id":"A1538","pred":"tao:has_database_id","subj":"1538","obj":"MESH:D009369"},{"id":"A1539","pred":"tao:has_database_id","subj":"1539","obj":"CVCL:0063"},{"id":"A1540","pred":"tao:has_database_id","subj":"1540","obj":"CVCL:0023"},{"id":"A1541","pred":"tao:has_database_id","subj":"1541","obj":"CVCL:0440"},{"id":"A1542","pred":"tao:has_database_id","subj":"1542","obj":"CVCL:4582"},{"id":"A1543","pred":"tao:has_database_id","subj":"1543","obj":"CVCL:0030"},{"id":"A1544","pred":"tao:has_database_id","subj":"1544","obj":"CVCL:0336"},{"id":"A1545","pred":"tao:has_database_id","subj":"1545","obj":"CVCL:L687"},{"id":"A1546","pred":"tao:has_database_id","subj":"1546","obj":"CVCL:0030"},{"id":"A1547","pred":"tao:has_database_id","subj":"1547","obj":"CVCL:0030"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Human embryonic kidney cell line 293 (#CRL-1573) and 293T expressing the SV40 T-antigen (#CRL-3216), human airway epithelial cell line Calu3 (#HTB-55), human alveolar epithelial cell line A549 (#CCL-185), human fibroblasts derived from lung tissue MRC5 (#CCL-171), African green monkey kidney cell line Vero E6 (#CRL-1586) and Vero 81 (#CCL-81), and human cervical carcinoma cell line HeLa(#CCL-2) were obtained from ATCC (Manassas, VA, USA). Human carcinoma cell line derived from hepatocyte Huh7 was kindly provided by Dr. Wei Yang (Chinese Academy of Medical Sciences, Beijing, China). Bat embryo fibroblast cells RS were isolated mid-gestation fetuses from Rhinolophus sinicus bat. HEK 239 cells stably expressing recombinant human ACE2 (293/hACE2), baby hamster kidney fibroblasts stably expressing recombinant human APN (BHK/hAPN), HeLa cells stably expressing recombinant human DPP4 (HeLa/hDPP4) were established in our lab by overexpression of these receptors. All above cells were maintained in Dulbecco’s MEM containing 10% fetal bovine serum and 100 unit penicillin, 100 μg streptomycin, and 0.25 μg Fungizone (1% PSF, Gibco) per milliliter. Rhesus monkeys kidney cell line LLC-MK2 (#CCL-7) from ATCC was maintained in Opti-MEM containing 10% FBS and 1%PSF."}