PMC:7100515 / 34476-35028 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7100515","sourcedb":"PMC","sourceid":"7100515","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7100515","text":"In conclusion, we demonstrated that SARS-CoV-2 S protein entry on 293/hACE2 cells is mainly mediated through endocytosis, and that PIKfyve, TPC2, and cathepsin L are critical for virus entry. We further found that SARS-CoV-2 S protein could trigger syncytia in 293/hACE2 cells independent of exogenous protease. Finally, there was limited cross-neutralization activity between convalescent sera from SARS and COVID-19 patients. Our findings provide potential targets for development of drugs and vaccines against this newly emerging lineage B beta-CoV.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T285","span":{"begin":49,"end":56},"obj":"Body_part"},{"id":"T286","span":{"begin":76,"end":81},"obj":"Body_part"},{"id":"T287","span":{"begin":227,"end":234},"obj":"Body_part"},{"id":"T288","span":{"begin":271,"end":276},"obj":"Body_part"}],"attributes":[{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T334","span":{"begin":36,"end":44},"obj":"Disease"},{"id":"T335","span":{"begin":214,"end":222},"obj":"Disease"},{"id":"T336","span":{"begin":400,"end":404},"obj":"Disease"},{"id":"T337","span":{"begin":409,"end":417},"obj":"Disease"}],"attributes":[{"id":"A334","pred":"mondo_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A335","pred":"mondo_id","subj":"T335","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A336","pred":"mondo_id","subj":"T336","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A337","pred":"mondo_id","subj":"T337","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T733","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T734","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T735","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T736","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T737","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T738","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T739","span":{"begin":66,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T740","span":{"begin":76,"end":81},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T741","span":{"begin":179,"end":184},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T742","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T743","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T744","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T745","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T746","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T747","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T748","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T749","span":{"begin":271,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T750","span":{"begin":360,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T751","span":{"begin":541,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T733","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T734","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T735","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T736","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T737","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T738","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T739","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T740","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T741","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T742","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T743","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T744","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T745","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T746","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T747","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T748","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T749","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T750","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T751","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T264","span":{"begin":49,"end":56},"obj":"Chemical"},{"id":"T265","span":{"begin":227,"end":234},"obj":"Chemical"},{"id":"T266","span":{"begin":486,"end":491},"obj":"Chemical"},{"id":"T267","span":{"begin":543,"end":547},"obj":"Chemical"}],"attributes":[{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T75","span":{"begin":109,"end":120},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"attributes":[{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T251","span":{"begin":0,"end":191},"obj":"Sentence"},{"id":"T252","span":{"begin":192,"end":311},"obj":"Sentence"},{"id":"T253","span":{"begin":312,"end":427},"obj":"Sentence"},{"id":"T254","span":{"begin":428,"end":552},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T251","pred":"source","obj":"LitCovid-sentences"},{"subj":"T252","pred":"source","obj":"LitCovid-sentences"},{"subj":"T253","pred":"source","obj":"LitCovid-sentences"},{"subj":"T254","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1441","span":{"begin":70,"end":75},"obj":"Gene"},{"id":"1442","span":{"begin":140,"end":144},"obj":"Gene"},{"id":"1443","span":{"begin":150,"end":161},"obj":"Gene"},{"id":"1444","span":{"begin":265,"end":270},"obj":"Gene"},{"id":"1445","span":{"begin":225,"end":226},"obj":"Gene"},{"id":"1446","span":{"begin":47,"end":48},"obj":"Gene"},{"id":"1447","span":{"begin":36,"end":46},"obj":"Species"},{"id":"1448","span":{"begin":214,"end":224},"obj":"Species"},{"id":"1449","span":{"begin":418,"end":426},"obj":"Species"},{"id":"1450","span":{"begin":543,"end":551},"obj":"Species"},{"id":"1451","span":{"begin":409,"end":417},"obj":"Disease"}],"attributes":[{"id":"A1441","pred":"tao:has_database_id","subj":"1441","obj":"Gene:59272"},{"id":"A1442","pred":"tao:has_database_id","subj":"1442","obj":"Gene:219931"},{"id":"A1443","pred":"tao:has_database_id","subj":"1443","obj":"Gene:1514"},{"id":"A1444","pred":"tao:has_database_id","subj":"1444","obj":"Gene:59272"},{"id":"A1445","pred":"tao:has_database_id","subj":"1445","obj":"Gene:43740568"},{"id":"A1446","pred":"tao:has_database_id","subj":"1446","obj":"Gene:43740568"},{"id":"A1447","pred":"tao:has_database_id","subj":"1447","obj":"Tax:2697049"},{"id":"A1448","pred":"tao:has_database_id","subj":"1448","obj":"Tax:2697049"},{"id":"A1449","pred":"tao:has_database_id","subj":"1449","obj":"Tax:9606"},{"id":"A1450","pred":"tao:has_database_id","subj":"1450","obj":"Tax:694002"},{"id":"A1451","pred":"tao:has_database_id","subj":"1451","obj":"MESH:C000657245"},{"subj":"1441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1450","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1451","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ec99","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93a6"},{"id":"LitCovid-PD-CLO","color":"#93c0ec"},{"id":"LitCovid-PD-CHEBI","color":"#daec93"},{"id":"LitCovid-PD-GO-BP","color":"#e393ec"},{"id":"LitCovid-sentences","color":"#93ecc9"},{"id":"LitCovid-PubTator","color":"#ecaf93"}]}]}}