PMC:7100515 / 29058-29763 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T243","span":{"begin":513,"end":520},"obj":"Body_part"},{"id":"T244","span":{"begin":610,"end":614},"obj":"Body_part"}],"attributes":[{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T281","span":{"begin":151,"end":159},"obj":"Disease"},{"id":"T282","span":{"begin":194,"end":203},"obj":"Disease"},{"id":"T283","span":{"begin":524,"end":532},"obj":"Disease"},{"id":"T284","span":{"begin":592,"end":600},"obj":"Disease"}],"attributes":[{"id":"A281","pred":"mondo_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A282","pred":"mondo_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A283","pred":"mondo_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A284","pred":"mondo_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T646","span":{"begin":46,"end":52},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T647","span":{"begin":68,"end":75},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T648","span":{"begin":170,"end":175},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T649","span":{"begin":255,"end":258},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T650","span":{"begin":387,"end":392},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T651","span":{"begin":411,"end":412},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T652","span":{"begin":486,"end":487},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T653","span":{"begin":544,"end":549},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T654","span":{"begin":610,"end":614},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T655","span":{"begin":653,"end":658},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T218","span":{"begin":513,"end":520},"obj":"Chemical"},{"id":"T219","span":{"begin":693,"end":697},"obj":"Chemical"}],"attributes":[{"id":"A218","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T54","span":{"begin":659,"end":671},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":194,"end":203},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-sentences","denotations":[{"id":"T217","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T218","span":{"begin":133,"end":332},"obj":"Sentence"},{"id":"T219","span":{"begin":333,"end":376},"obj":"Sentence"},{"id":"T220","span":{"begin":377,"end":573},"obj":"Sentence"},{"id":"T221","span":{"begin":574,"end":705},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"2_test","denotations":[{"id":"32221306-17445320-73894038","span":{"begin":129,"end":131},"obj":"17445320"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1231","span":{"begin":511,"end":512},"obj":"Gene"},{"id":"1232","span":{"begin":46,"end":52},"obj":"Species"},{"id":"1233","span":{"begin":81,"end":85},"obj":"Species"},{"id":"1234","span":{"begin":151,"end":161},"obj":"Species"},{"id":"1235","span":{"begin":170,"end":175},"obj":"Species"},{"id":"1236","span":{"begin":524,"end":534},"obj":"Species"},{"id":"1237","span":{"begin":592,"end":602},"obj":"Species"},{"id":"1238","span":{"begin":194,"end":203},"obj":"Disease"},{"id":"1239","span":{"begin":323,"end":329},"obj":"Disease"}],"attributes":[{"id":"A1231","pred":"tao:has_database_id","subj":"1231","obj":"Gene:43740568"},{"id":"A1232","pred":"tao:has_database_id","subj":"1232","obj":"Tax:9606"},{"id":"A1233","pred":"tao:has_database_id","subj":"1233","obj":"Tax:11118"},{"id":"A1234","pred":"tao:has_database_id","subj":"1234","obj":"Tax:2697049"},{"id":"A1235","pred":"tao:has_database_id","subj":"1235","obj":"Tax:9606"},{"id":"A1236","pred":"tao:has_database_id","subj":"1236","obj":"Tax:2697049"},{"id":"A1237","pred":"tao:has_database_id","subj":"1237","obj":"Tax:2697049"},{"id":"A1238","pred":"tao:has_database_id","subj":"1238","obj":"MESH:D011014"},{"id":"A1239","pred":"tao:has_database_id","subj":"1239","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"About 70% of the emerging pathogens infecting humans originate from animals, and CoVs are among the forefronts of these pathogens45. The newly emerged SARS-CoV-2 infects human and causes severe pneumonia, and as of 10 February, 2020, the current outbreak has spread to 25 countries with over 40,000 confirmed cases and 900 deaths46. However, little is known about its biology. Since the virus is categorized as a biosafety level 3 (BSL3) agent, according to WHO guideline, we developed a pseudotype system with S protein of SARS-CoV-2 to study virus entry in BSL2 settings. Understanding how SARS-CoV-2 enters cell will provide valuable information for virus pathogenesis, vaccine design, and drug target."}