PMC:7100515 / 18455-20113 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7100515","sourcedb":"PMC","sourceid":"7100515","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7100515","text":"Activation of SARS-CoV-2 S protein by cathepsin and trypsin.\na Effects of cathepsin inhibitors on entry of SARS-CoV-2 S pseudovirions on 293/hACE2 cells. HEK 293/hACE2 cells were pretreated with broad-spectrum cathepsin inhibitor E64D, cathepsin L-specific inhibitor (SID 26681509), or cathepsin B-specific inhibitor (CA-074) and then transduced with SARS-CoV-2 S and VSV-G pseudovirions. Pseudoviral transduction was measured at 40 h post inoculation. Experiments were done in triplicates and repeated at least three times. One representative is shown. Error bars indicate SEM of technical triplicates. b Cell–cell fusion mediated by SARS-CoV-2 S protein. HEK 293T cells were transiently expressing eGFP and either SARS-CoV-2 or SARS-CoV S protein were detached with either trypsin or EDTA, and co-cultured with 293/hACE2 or 293 cells for 4 h at 37 °C. The scale bar indicates 250 µm. c Quantitative analysis of syncytia in panel b. d, e Thermostability analysis of SARS-CoV-2 S protein. d SARS-CoV and SARS-CoV-2 S pseudovirons were incubated at 37 °C for the specified times (0 to 4 h) in the absence of serum, and then assayed on 293/hACE2 cells. The results from infection at 0 h were set as 100%, and the experiments were repeated four times, and means with standard deviations are shown. e SARS-CoV and SARS-CoV-2 S pseudovirions without serum were incubated at the indicated temperature (37 to 51 °C) for 2 h and then assayed on 293/hACE2 cells. The results are reported as the percentage of transduction at 37 °C. The experiments were repeated four times, and means with standard deviations are shown. Source data are provided as a Source Data file.","divisions":[{"label":"title","span":{"begin":0,"end":60}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T153","span":{"begin":27,"end":34},"obj":"Body_part"},{"id":"T154","span":{"begin":147,"end":152},"obj":"Body_part"},{"id":"T155","span":{"begin":168,"end":173},"obj":"Body_part"},{"id":"T156","span":{"begin":606,"end":610},"obj":"Body_part"},{"id":"T157","span":{"begin":611,"end":615},"obj":"Body_part"},{"id":"T158","span":{"begin":648,"end":655},"obj":"Body_part"},{"id":"T159","span":{"begin":666,"end":671},"obj":"Body_part"},{"id":"T160","span":{"begin":741,"end":748},"obj":"Body_part"},{"id":"T161","span":{"begin":830,"end":835},"obj":"Body_part"},{"id":"T162","span":{"begin":980,"end":987},"obj":"Body_part"},{"id":"T163","span":{"begin":1107,"end":1112},"obj":"Body_part"},{"id":"T164","span":{"begin":1144,"end":1149},"obj":"Body_part"},{"id":"T165","span":{"begin":1345,"end":1350},"obj":"Body_part"},{"id":"T166","span":{"begin":1447,"end":1452},"obj":"Body_part"}],"attributes":[{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":858,"end":863},"obj":"Body_part"},{"id":"T4","span":{"begin":1107,"end":1112},"obj":"Body_part"},{"id":"T5","span":{"begin":1345,"end":1350},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T146","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T147","span":{"begin":107,"end":115},"obj":"Disease"},{"id":"T148","span":{"begin":351,"end":359},"obj":"Disease"},{"id":"T149","span":{"begin":635,"end":643},"obj":"Disease"},{"id":"T150","span":{"begin":716,"end":724},"obj":"Disease"},{"id":"T151","span":{"begin":730,"end":738},"obj":"Disease"},{"id":"T152","span":{"begin":967,"end":975},"obj":"Disease"},{"id":"T153","span":{"begin":991,"end":999},"obj":"Disease"},{"id":"T154","span":{"begin":1004,"end":1012},"obj":"Disease"},{"id":"T155","span":{"begin":1168,"end":1177},"obj":"Disease"},{"id":"T156","span":{"begin":1297,"end":1305},"obj":"Disease"},{"id":"T157","span":{"begin":1310,"end":1318},"obj":"Disease"}],"attributes":[{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A155","pred":"mondo_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A156","pred":"mondo_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A157","pred":"mondo_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T434","span":{"begin":0,"end":10},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T435","span":{"begin":61,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T436","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T437","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T438","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T439","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T440","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T441","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T442","span":{"begin":137,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T443","span":{"begin":147,"end":152},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T444","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T445","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T446","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T447","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T448","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T449","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T450","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T451","span":{"begin":168,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T452","span":{"begin":296,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T453","span":{"begin":604,"end":610},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T454","span":{"begin":611,"end":615},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T455","span":{"begin":661,"end":665},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T456","span":{"begin":661,"end":665},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T457","span":{"begin":661,"end":665},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T458","span":{"begin":666,"end":671},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T459","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T460","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T461","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T462","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T463","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T464","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T465","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T466","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T467","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T468","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T469","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T470","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T471","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T472","span":{"begin":826,"end":829},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T473","span":{"begin":830,"end":835},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T474","span":{"begin":931,"end":932},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T475","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T476","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T477","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T478","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T479","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T480","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T481","span":{"begin":1134,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T482","span":{"begin":1144,"end":1149},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T483","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T484","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T485","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T486","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T487","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T488","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T489","span":{"begin":1437,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T490","span":{"begin":1447,"end":1452},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T491","span":{"begin":1639,"end":1640},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T445","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T452","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T453","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T454","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T456","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T457","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T460","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T462","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T463","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T465","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T467","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T468","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T469","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T470","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T471","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T472","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T473","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T474","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T475","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T476","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T477","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T478","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T479","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T480","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T481","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T482","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T483","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T484","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T488","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T489","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T491","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T161","span":{"begin":27,"end":34},"obj":"Chemical"},{"id":"T162","span":{"begin":84,"end":94},"obj":"Chemical"},{"id":"T163","span":{"begin":220,"end":229},"obj":"Chemical"},{"id":"T164","span":{"begin":257,"end":266},"obj":"Chemical"},{"id":"T165","span":{"begin":307,"end":316},"obj":"Chemical"},{"id":"T166","span":{"begin":648,"end":655},"obj":"Chemical"},{"id":"T167","span":{"begin":741,"end":748},"obj":"Chemical"},{"id":"T168","span":{"begin":786,"end":790},"obj":"Chemical"},{"id":"T170","span":{"begin":980,"end":987},"obj":"Chemical"}],"attributes":[{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A165","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A168","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_42191"},{"id":"A169","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_64755"},{"id":"A170","pred":"chebi_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":401,"end":413},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T27","span":{"begin":611,"end":622},"obj":"http://purl.obolibrary.org/obo/GO_0140253"},{"id":"T28","span":{"begin":611,"end":622},"obj":"http://purl.obolibrary.org/obo/GO_0045026"},{"id":"T29","span":{"begin":611,"end":622},"obj":"http://purl.obolibrary.org/obo/GO_0000768"},{"id":"T30","span":{"begin":611,"end":622},"obj":"http://purl.obolibrary.org/obo/GO_0000747"},{"id":"T31","span":{"begin":1500,"end":1512},"obj":"http://purl.obolibrary.org/obo/GO_0009293"}],"attributes":[{"subj":"T26","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T136","span":{"begin":61,"end":153},"obj":"Sentence"},{"id":"T137","span":{"begin":154,"end":388},"obj":"Sentence"},{"id":"T138","span":{"begin":389,"end":452},"obj":"Sentence"},{"id":"T139","span":{"begin":453,"end":524},"obj":"Sentence"},{"id":"T140","span":{"begin":525,"end":553},"obj":"Sentence"},{"id":"T141","span":{"begin":554,"end":656},"obj":"Sentence"},{"id":"T142","span":{"begin":657,"end":853},"obj":"Sentence"},{"id":"T143","span":{"begin":854,"end":1150},"obj":"Sentence"},{"id":"T144","span":{"begin":1151,"end":1453},"obj":"Sentence"},{"id":"T145","span":{"begin":1454,"end":1522},"obj":"Sentence"},{"id":"T146","span":{"begin":1523,"end":1610},"obj":"Sentence"},{"id":"T147","span":{"begin":1611,"end":1658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T136","pred":"source","obj":"LitCovid-sentences"},{"subj":"T137","pred":"source","obj":"LitCovid-sentences"},{"subj":"T138","pred":"source","obj":"LitCovid-sentences"},{"subj":"T139","pred":"source","obj":"LitCovid-sentences"},{"subj":"T140","pred":"source","obj":"LitCovid-sentences"},{"subj":"T141","pred":"source","obj":"LitCovid-sentences"},{"subj":"T142","pred":"source","obj":"LitCovid-sentences"},{"subj":"T143","pred":"source","obj":"LitCovid-sentences"},{"subj":"T144","pred":"source","obj":"LitCovid-sentences"},{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"760","span":{"begin":25,"end":26},"obj":"Gene"},{"id":"761","span":{"begin":14,"end":24},"obj":"Species"},{"id":"792","span":{"begin":141,"end":146},"obj":"Gene"},{"id":"793","span":{"begin":162,"end":167},"obj":"Gene"},{"id":"794","span":{"begin":236,"end":247},"obj":"Gene"},{"id":"795","span":{"begin":286,"end":297},"obj":"Gene"},{"id":"796","span":{"begin":817,"end":822},"obj":"Gene"},{"id":"797","span":{"begin":1138,"end":1143},"obj":"Gene"},{"id":"798","span":{"begin":1441,"end":1446},"obj":"Gene"},{"id":"799","span":{"begin":1321,"end":1322},"obj":"Gene"},{"id":"800","span":{"begin":1015,"end":1016},"obj":"Gene"},{"id":"801","span":{"begin":978,"end":979},"obj":"Gene"},{"id":"802","span":{"begin":646,"end":647},"obj":"Gene"},{"id":"803","span":{"begin":362,"end":363},"obj":"Gene"},{"id":"804","span":{"begin":118,"end":119},"obj":"Gene"},{"id":"805","span":{"begin":107,"end":117},"obj":"Species"},{"id":"806","span":{"begin":351,"end":361},"obj":"Species"},{"id":"807","span":{"begin":635,"end":645},"obj":"Species"},{"id":"808","span":{"begin":716,"end":726},"obj":"Species"},{"id":"809","span":{"begin":730,"end":738},"obj":"Species"},{"id":"810","span":{"begin":967,"end":977},"obj":"Species"},{"id":"811","span":{"begin":991,"end":999},"obj":"Species"},{"id":"812","span":{"begin":1004,"end":1014},"obj":"Species"},{"id":"813","span":{"begin":1297,"end":1305},"obj":"Species"},{"id":"814","span":{"begin":1310,"end":1320},"obj":"Species"},{"id":"815","span":{"begin":268,"end":280},"obj":"Chemical"},{"id":"816","span":{"begin":318,"end":324},"obj":"Chemical"},{"id":"817","span":{"begin":786,"end":790},"obj":"Chemical"},{"id":"818","span":{"begin":1168,"end":1177},"obj":"Disease"},{"id":"819","span":{"begin":154,"end":161},"obj":"CellLine"},{"id":"820","span":{"begin":657,"end":665},"obj":"CellLine"},{"id":"821","span":{"begin":826,"end":835},"obj":"CellLine"}],"attributes":[{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"Gene:43740568"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"Tax:2697049"},{"id":"A792","pred":"tao:has_database_id","subj":"792","obj":"Gene:59272"},{"id":"A793","pred":"tao:has_database_id","subj":"793","obj":"Gene:59272"},{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"Gene:1514"},{"id":"A795","pred":"tao:has_database_id","subj":"795","obj":"Gene:1508"},{"id":"A796","pred":"tao:has_database_id","subj":"796","obj":"Gene:59272"},{"id":"A797","pred":"tao:has_database_id","subj":"797","obj":"Gene:59272"},{"id":"A798","pred":"tao:has_database_id","subj":"798","obj":"Gene:59272"},{"id":"A799","pred":"tao:has_database_id","subj":"799","obj":"Gene:43740568"},{"id":"A800","pred":"tao:has_database_id","subj":"800","obj":"Gene:43740568"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"Gene:43740568"},{"id":"A802","pred":"tao:has_database_id","subj":"802","obj":"Gene:43740568"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"Gene:43740568"},{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"Gene:43740568"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Tax:2697049"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Tax:2697049"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Tax:2697049"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Tax:2697049"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Tax:694009"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"Tax:2697049"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"Tax:694009"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"Tax:2697049"},{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"Tax:694009"},{"id":"A814","pred":"tao:has_database_id","subj":"814","obj":"Tax:2697049"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"MESH:C576116"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"MESH:C068250"},{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"MESH:D004492"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"MESH:D007239"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"CVCL:0045"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"CVCL:0063"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"CVCL:0045"},{"subj":"760","pred":"source","obj":"LitCovid-PubTator"},{"subj":"761","pred":"source","obj":"LitCovid-PubTator"},{"subj":"792","pred":"source","obj":"LitCovid-PubTator"},{"subj":"793","pred":"source","obj":"LitCovid-PubTator"},{"subj":"794","pred":"source","obj":"LitCovid-PubTator"},{"subj":"795","pred":"source","obj":"LitCovid-PubTator"},{"subj":"796","pred":"source","obj":"LitCovid-PubTator"},{"subj":"797","pred":"source","obj":"LitCovid-PubTator"},{"subj":"798","pred":"source","obj":"LitCovid-PubTator"},{"subj":"799","pred":"source","obj":"LitCovid-PubTator"},{"subj":"800","pred":"source","obj":"LitCovid-PubTator"},{"subj":"801","pred":"source","obj":"LitCovid-PubTator"},{"subj":"802","pred":"source","obj":"LitCovid-PubTator"},{"subj":"803","pred":"source","obj":"LitCovid-PubTator"},{"subj":"804","pred":"source","obj":"LitCovid-PubTator"},{"subj":"805","pred":"source","obj":"LitCovid-PubTator"},{"subj":"806","pred":"source","obj":"LitCovid-PubTator"},{"subj":"807","pred":"source","obj":"LitCovid-PubTator"},{"subj":"808","pred":"source","obj":"LitCovid-PubTator"},{"subj":"809","pred":"source","obj":"LitCovid-PubTator"},{"subj":"810","pred":"source","obj":"LitCovid-PubTator"},{"subj":"811","pred":"source","obj":"LitCovid-PubTator"},{"subj":"812","pred":"source","obj":"LitCovid-PubTator"},{"subj":"813","pred":"source","obj":"LitCovid-PubTator"},{"subj":"814","pred":"source","obj":"LitCovid-PubTator"},{"subj":"815","pred":"source","obj":"LitCovid-PubTator"},{"subj":"816","pred":"source","obj":"LitCovid-PubTator"},{"subj":"817","pred":"source","obj":"LitCovid-PubTator"},{"subj":"818","pred":"source","obj":"LitCovid-PubTator"},{"subj":"819","pred":"source","obj":"LitCovid-PubTator"},{"subj":"820","pred":"source","obj":"LitCovid-PubTator"},{"subj":"821","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9593ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#aaec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93c4"},{"id":"LitCovid-PD-CLO","color":"#93deec"},{"id":"LitCovid-PD-CHEBI","color":"#ece093"},{"id":"LitCovid-PD-GO-BP","color":"#c693ec"},{"id":"LitCovid-sentences","color":"#93ecac"},{"id":"LitCovid-PubTator","color":"#ec9394"}]}]}}