PMC:7100515 / 18448-20113
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T153 | 34-41 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T154 | 154-159 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T155 | 175-180 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T156 | 613-617 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T157 | 618-622 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T158 | 655-662 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T159 | 673-678 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T160 | 748-755 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T161 | 837-842 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T162 | 987-994 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T163 | 1114-1119 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T164 | 1151-1156 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T165 | 1352-1357 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T166 | 1454-1459 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 865-870 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
| T4 | 1114-1119 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T5 | 1352-1357 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T146 | 21-29 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T147 | 114-122 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T148 | 358-366 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T149 | 642-650 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T150 | 723-731 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T151 | 737-745 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T152 | 974-982 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T153 | 998-1006 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T154 | 1011-1019 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T155 | 1175-1184 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T156 | 1304-1312 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T157 | 1317-1325 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T434 | 7-17 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T435 | 68-69 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T436 | 144-147 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T437 | 144-147 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T438 | 144-147 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T439 | 144-147 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T440 | 144-147 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T441 | 144-147 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T442 | 144-147 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T443 | 154-159 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T444 | 165-168 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T445 | 165-168 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T446 | 165-168 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T447 | 165-168 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T448 | 165-168 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T449 | 165-168 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T450 | 165-168 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T451 | 175-180 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T452 | 303-304 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T453 | 611-617 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | b Cell |
| T454 | 618-622 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T455 | 668-672 | http://purl.obolibrary.org/obo/CLO_0050894 | denotes | 293T |
| T456 | 668-672 | http://purl.obolibrary.org/obo/CLO_0051650 | denotes | 293T |
| T457 | 668-672 | http://purl.obolibrary.org/obo/CLO_0052052 | denotes | 293T |
| T458 | 673-678 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T459 | 820-823 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T460 | 820-823 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T461 | 820-823 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T462 | 820-823 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T463 | 820-823 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T464 | 820-823 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T465 | 820-823 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T466 | 833-836 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T467 | 833-836 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T468 | 833-836 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T469 | 833-836 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T470 | 833-836 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T471 | 833-836 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T472 | 833-836 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T473 | 837-842 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T474 | 938-939 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T475 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T476 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T477 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T478 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T479 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T480 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T481 | 1141-1144 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T482 | 1151-1156 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T483 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
| T484 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
| T485 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
| T486 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
| T487 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
| T488 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
| T489 | 1444-1447 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
| T490 | 1454-1459 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T491 | 1646-1647 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T161 | 34-41 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T162 | 91-101 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T163 | 227-236 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T164 | 264-273 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T165 | 314-323 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T166 | 655-662 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T167 | 748-755 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T168 | 793-797 | Chemical | denotes | EDTA | http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755 |
| T170 | 987-994 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T26 | 408-420 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T27 | 618-629 | http://purl.obolibrary.org/obo/GO_0140253 | denotes | cell fusion |
| T28 | 618-629 | http://purl.obolibrary.org/obo/GO_0045026 | denotes | cell fusion |
| T29 | 618-629 | http://purl.obolibrary.org/obo/GO_0000768 | denotes | cell fusion |
| T30 | 618-629 | http://purl.obolibrary.org/obo/GO_0000747 | denotes | cell fusion |
| T31 | 1507-1519 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T135 | 0-67 | Sentence | denotes | Fig. 4 Activation of SARS-CoV-2 S protein by cathepsin and trypsin. |
| T136 | 68-160 | Sentence | denotes | a Effects of cathepsin inhibitors on entry of SARS-CoV-2 S pseudovirions on 293/hACE2 cells. |
| T137 | 161-395 | Sentence | denotes | HEK 293/hACE2 cells were pretreated with broad-spectrum cathepsin inhibitor E64D, cathepsin L-specific inhibitor (SID 26681509), or cathepsin B-specific inhibitor (CA-074) and then transduced with SARS-CoV-2 S and VSV-G pseudovirions. |
| T138 | 396-459 | Sentence | denotes | Pseudoviral transduction was measured at 40 h post inoculation. |
| T139 | 460-531 | Sentence | denotes | Experiments were done in triplicates and repeated at least three times. |
| T140 | 532-560 | Sentence | denotes | One representative is shown. |
| T141 | 561-663 | Sentence | denotes | Error bars indicate SEM of technical triplicates. b Cell–cell fusion mediated by SARS-CoV-2 S protein. |
| T142 | 664-860 | Sentence | denotes | HEK 293T cells were transiently expressing eGFP and either SARS-CoV-2 or SARS-CoV S protein were detached with either trypsin or EDTA, and co-cultured with 293/hACE2 or 293 cells for 4 h at 37 °C. |
| T143 | 861-1157 | Sentence | denotes | The scale bar indicates 250 µm. c Quantitative analysis of syncytia in panel b. d, e Thermostability analysis of SARS-CoV-2 S protein. d SARS-CoV and SARS-CoV-2 S pseudovirons were incubated at 37 °C for the specified times (0 to 4 h) in the absence of serum, and then assayed on 293/hACE2 cells. |
| T144 | 1158-1460 | Sentence | denotes | The results from infection at 0 h were set as 100%, and the experiments were repeated four times, and means with standard deviations are shown. e SARS-CoV and SARS-CoV-2 S pseudovirions without serum were incubated at the indicated temperature (37 to 51 °C) for 2 h and then assayed on 293/hACE2 cells. |
| T145 | 1461-1529 | Sentence | denotes | The results are reported as the percentage of transduction at 37 °C. |
| T146 | 1530-1617 | Sentence | denotes | The experiments were repeated four times, and means with standard deviations are shown. |
| T147 | 1618-1665 | Sentence | denotes | Source data are provided as a Source Data file. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 760 | 32-33 | Gene | denotes | S | Gene:43740568 |
| 761 | 21-31 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 792 | 148-153 | Gene | denotes | hACE2 | Gene:59272 |
| 793 | 169-174 | Gene | denotes | hACE2 | Gene:59272 |
| 794 | 243-254 | Gene | denotes | cathepsin L | Gene:1514 |
| 795 | 293-304 | Gene | denotes | cathepsin B | Gene:1508 |
| 796 | 824-829 | Gene | denotes | hACE2 | Gene:59272 |
| 797 | 1145-1150 | Gene | denotes | hACE2 | Gene:59272 |
| 798 | 1448-1453 | Gene | denotes | hACE2 | Gene:59272 |
| 799 | 1328-1329 | Gene | denotes | S | Gene:43740568 |
| 800 | 1022-1023 | Gene | denotes | S | Gene:43740568 |
| 801 | 985-986 | Gene | denotes | S | Gene:43740568 |
| 802 | 653-654 | Gene | denotes | S | Gene:43740568 |
| 803 | 369-370 | Gene | denotes | S | Gene:43740568 |
| 804 | 125-126 | Gene | denotes | S | Gene:43740568 |
| 805 | 114-124 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 806 | 358-368 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 807 | 642-652 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 808 | 723-733 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 809 | 737-745 | Species | denotes | SARS-CoV | Tax:694009 |
| 810 | 974-984 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 811 | 998-1006 | Species | denotes | SARS-CoV | Tax:694009 |
| 812 | 1011-1021 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 813 | 1304-1312 | Species | denotes | SARS-CoV | Tax:694009 |
| 814 | 1317-1327 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 815 | 275-287 | Chemical | denotes | SID 26681509 | MESH:C576116 |
| 816 | 325-331 | Chemical | denotes | CA-074 | MESH:C068250 |
| 817 | 793-797 | Chemical | denotes | EDTA | MESH:D004492 |
| 818 | 1175-1184 | Disease | denotes | infection | MESH:D007239 |
| 819 | 161-168 | CellLine | denotes | HEK 293 | CVCL:0045 |
| 820 | 664-672 | CellLine | denotes | HEK 293T | CVCL:0063 |
| 821 | 833-842 | CellLine | denotes | 293 cells | CVCL:0045 |