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PMC:7100515 / 17312-20113 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T146 76-83 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 146-154 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T148 322-327 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 642-647 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T150 1084-1091 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T151 1095-1103 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T152 1129-1134 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 1170-1177 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 1290-1295 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 1311-1316 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 1749-1753 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T157 1754-1758 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T158 1791-1798 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T159 1809-1814 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T160 1884-1891 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T161 1973-1978 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 2123-2130 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 2250-2255 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T164 2287-2292 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T165 2488-2493 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T166 2590-2595 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 2001-2006 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 2250-2255 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T5 2488-2493 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T139 34-42 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 190-198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 290-298 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 665-673 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 778-786 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 943-951 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 1071-1079 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 1157-1165 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 1250-1258 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 1494-1502 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T149 1778-1786 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T150 1859-1867 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 1873-1881 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T152 2110-2118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T153 2134-2142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 2147-2155 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 2311-2320 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T156 2440-2448 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T157 2453-2461 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T392 60-70 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T393 146-154 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T394 312-315 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T395 312-315 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T396 312-315 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T397 312-315 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T398 312-315 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T399 312-315 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T400 312-315 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T401 322-327 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T402 353-354 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T403 385-386 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T404 465-466 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T405 520-521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T406 546-551 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T407 602-612 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T408 632-635 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T409 632-635 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T410 632-635 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T411 632-635 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T412 632-635 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T413 632-635 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T414 632-635 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T415 642-647 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T416 822-823 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T417 878-883 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T418 975-978 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T419 975-978 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T420 975-978 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T421 975-978 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T422 975-978 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T423 975-978 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T424 975-978 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T425 1095-1103 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T426 1119-1122 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T427 1119-1122 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T428 1119-1122 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T429 1119-1122 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T430 1119-1122 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T431 1119-1122 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T432 1119-1122 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T433 1129-1134 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T434 1143-1153 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T435 1204-1205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T436 1280-1283 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T437 1280-1283 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T438 1280-1283 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T439 1280-1283 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T440 1280-1283 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T441 1280-1283 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T442 1280-1283 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T443 1290-1295 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T444 1301-1304 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T445 1301-1304 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T446 1301-1304 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T447 1301-1304 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T448 1301-1304 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T449 1301-1304 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T450 1301-1304 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T451 1311-1316 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T452 1439-1440 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T453 1747-1753 http://purl.obolibrary.org/obo/CL_0000236 denotes b Cell
T454 1754-1758 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T455 1804-1808 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T456 1804-1808 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T457 1804-1808 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T458 1809-1814 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T459 1956-1959 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T460 1956-1959 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T461 1956-1959 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T462 1956-1959 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T463 1956-1959 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T464 1956-1959 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T465 1956-1959 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T466 1969-1972 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T467 1969-1972 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T468 1969-1972 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T469 1969-1972 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T470 1969-1972 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T471 1969-1972 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T472 1969-1972 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T473 1973-1978 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T474 2074-2075 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T475 2277-2280 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T476 2277-2280 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T477 2277-2280 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T478 2277-2280 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T479 2277-2280 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T480 2277-2280 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T481 2277-2280 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T482 2287-2292 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T483 2580-2583 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T484 2580-2583 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T485 2580-2583 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T486 2580-2583 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T487 2580-2583 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T488 2580-2583 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T489 2580-2583 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T490 2590-2595 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T491 2782-2783 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T151 20-30 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T152 76-83 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T153 361-370 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T154 414-435 Chemical denotes cathepsin L inhibitor http://purl.obolibrary.org/obo/CHEBI_70821
T155 426-435 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T156 455-476 Chemical denotes cathepsin B inhibitor http://purl.obolibrary.org/obo/CHEBI_64932
T157 467-476 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T158 812-833 Chemical denotes cathepsin B inhibitor http://purl.obolibrary.org/obo/CHEBI_64932
T159 824-833 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T160 1084-1091 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 1170-1177 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 1227-1237 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T163 1363-1372 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T164 1400-1409 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T165 1450-1459 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T166 1791-1798 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T167 1884-1891 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T168 1929-1933 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T170 2123-2130 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T25 226-237 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T26 1544-1556 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T27 1754-1765 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T28 1754-1765 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T29 1754-1765 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T30 1754-1765 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T31 2643-2655 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T129 0-50 Sentence denotes Effect of cathepsin inhibitors on SARS-CoV-2 entry
T130 51-238 Sentence denotes Protease activation on S protein is an important step for coronavirus entry, and cathepsins in lysosome have been shown to be critical for SARS-CoV and MERS-CoV entry through endocytosis.
T131 239-486 Sentence denotes To investigate whether cathepsins are required for SARS-CoV-2 entry, HEK 293/hACE2 cells were treated with either a broad inhibitor for cathepsin B, H, L, and calpain (E64D), cathepsin L inhibitor (SID 26681509), or cathepsin B inhibitor (CA-074).
T132 487-613 Sentence denotes VSV-G pseudovirions were used as a negative control, since virus entry mediated by VSV-G does not require protease activation.
T133 614-805 Sentence denotes E64D treatment of 293/hACE2 cells reduced entry of SARS-CoV-2 S pseudovirions by 92.5%, indicating that at least one of cathepsins or calpain might be required for SARS-CoV-2 entry (Fig. 4a).
T134 806-1135 Sentence denotes While cathepsin B inhibitor treatment did not show any marked effect on virus entry, cathepsin L inhibition treatment decreased entry of SARS-CoV-2 S pseudovirions into 293/hACE2 by over 76% (Fig. 4a), suggesting that cathepsin L should be essential for priming of SARS-CoV-2 S protein in lysosome for entry into 293/hACE2 cells.
T135 1136-1203 Sentence denotes Fig. 4 Activation of SARS-CoV-2 S protein by cathepsin and trypsin.
T136 1204-1296 Sentence denotes a Effects of cathepsin inhibitors on entry of SARS-CoV-2 S pseudovirions on 293/hACE2 cells.
T137 1297-1531 Sentence denotes HEK 293/hACE2 cells were pretreated with broad-spectrum cathepsin inhibitor E64D, cathepsin L-specific inhibitor (SID 26681509), or cathepsin B-specific inhibitor (CA-074) and then transduced with SARS-CoV-2 S and VSV-G pseudovirions.
T138 1532-1595 Sentence denotes Pseudoviral transduction was measured at 40 h post inoculation.
T139 1596-1667 Sentence denotes Experiments were done in triplicates and repeated at least three times.
T140 1668-1696 Sentence denotes One representative is shown.
T141 1697-1799 Sentence denotes Error bars indicate SEM of technical triplicates. b Cell–cell fusion mediated by SARS-CoV-2 S protein.
T142 1800-1996 Sentence denotes HEK 293T cells were transiently expressing eGFP and either SARS-CoV-2 or SARS-CoV S protein were detached with either trypsin or EDTA, and co-cultured with 293/hACE2 or 293 cells for 4 h at 37 °C.
T143 1997-2293 Sentence denotes The scale bar indicates 250 µm. c Quantitative analysis of syncytia in panel b. d, e Thermostability analysis of SARS-CoV-2 S protein. d SARS-CoV and SARS-CoV-2 S pseudovirons were incubated at 37 °C for the specified times (0 to 4 h) in the absence of serum, and then assayed on 293/hACE2 cells.
T144 2294-2596 Sentence denotes The results from infection at 0 h were set as 100%, and the experiments were repeated four times, and means with standard deviations are shown. e SARS-CoV and SARS-CoV-2 S pseudovirions without serum were incubated at the indicated temperature (37 to 51 °C) for 2 h and then assayed on 293/hACE2 cells.
T145 2597-2665 Sentence denotes The results are reported as the percentage of transduction at 37 °C.
T146 2666-2753 Sentence denotes The experiments were repeated four times, and means with standard deviations are shown.
T147 2754-2801 Sentence denotes Source data are provided as a Source Data file.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
757 34-44 Species denotes SARS-CoV-2 Tax:2697049
760 1168-1169 Gene denotes S Gene:43740568
761 1157-1167 Species denotes SARS-CoV-2 Tax:2697049
792 1284-1289 Gene denotes hACE2 Gene:59272
793 1305-1310 Gene denotes hACE2 Gene:59272
794 1379-1390 Gene denotes cathepsin L Gene:1514
795 1429-1440 Gene denotes cathepsin B Gene:1508
796 1960-1965 Gene denotes hACE2 Gene:59272
797 2281-2286 Gene denotes hACE2 Gene:59272
798 2584-2589 Gene denotes hACE2 Gene:59272
799 2464-2465 Gene denotes S Gene:43740568
800 2158-2159 Gene denotes S Gene:43740568
801 2121-2122 Gene denotes S Gene:43740568
802 1789-1790 Gene denotes S Gene:43740568
803 1505-1506 Gene denotes S Gene:43740568
804 1261-1262 Gene denotes S Gene:43740568
805 1250-1260 Species denotes SARS-CoV-2 Tax:2697049
806 1494-1504 Species denotes SARS-CoV-2 Tax:2697049
807 1778-1788 Species denotes SARS-CoV-2 Tax:2697049
808 1859-1869 Species denotes SARS-CoV-2 Tax:2697049
809 1873-1881 Species denotes SARS-CoV Tax:694009
810 2110-2120 Species denotes SARS-CoV-2 Tax:2697049
811 2134-2142 Species denotes SARS-CoV Tax:694009
812 2147-2157 Species denotes SARS-CoV-2 Tax:2697049
813 2440-2448 Species denotes SARS-CoV Tax:694009
814 2453-2463 Species denotes SARS-CoV-2 Tax:2697049
815 1411-1423 Chemical denotes SID 26681509 MESH:C576116
816 1461-1467 Chemical denotes CA-074 MESH:C068250
817 1929-1933 Chemical denotes EDTA MESH:D004492
818 2311-2320 Disease denotes infection MESH:D007239
819 1297-1304 CellLine denotes HEK 293 CVCL:0045
820 1800-1808 CellLine denotes HEK 293T CVCL:0063
821 1969-1978 CellLine denotes 293 cells CVCL:0045
846 316-321 Gene denotes hACE2 Gene:59272
847 375-386 Gene denotes cathepsin B Gene:1508
848 414-425 Gene denotes cathepsin L Gene:1514
849 455-466 Gene denotes cathepsin B Gene:1508
850 636-641 Gene denotes hACE2 Gene:59272
851 812-823 Gene denotes cathepsin B Gene:1508
852 891-902 Gene denotes cathepsin L Gene:1514
853 979-984 Gene denotes hACE2 Gene:59272
854 1024-1035 Gene denotes cathepsin L Gene:1514
855 1123-1128 Gene denotes hACE2 Gene:59272
856 1082-1083 Gene denotes S Gene:43740568
857 954-955 Gene denotes S Gene:43740568
858 676-677 Gene denotes S Gene:43740568
859 109-120 Species denotes coronavirus Tax:11118
860 190-198 Species denotes SARS-CoV Tax:694009
861 203-211 Species denotes MERS-CoV Tax:1335626
862 290-300 Species denotes SARS-CoV-2 Tax:2697049
863 665-675 Species denotes SARS-CoV-2 Tax:2697049
864 778-788 Species denotes SARS-CoV-2 Tax:2697049
865 943-953 Species denotes SARS-CoV-2 Tax:2697049
866 1071-1081 Species denotes SARS-CoV-2 Tax:2697049
867 437-449 Chemical denotes SID 26681509 MESH:C576116
868 478-484 Chemical denotes CA-074 MESH:C068250
869 308-315 CellLine denotes HEK 293 CVCL:0045