PMC:7100515 / 15293-17310 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7100515","sourcedb":"PMC","sourceid":"7100515","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7100515","text":"PIKfyve and TPC2 critical for SARS-CoV-2 entry\nPhosphoinositides play many essential roles in endocytosis. Among them, one is phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2), which regulates early endosome to late endosome dynamics33,34. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is the main enzyme synthesizing PI(3,5)P2 in early endosome. HEK 293/hACE2 cells were treated with apilimod, a potent inhibitor for PIKfyve35. Inhibition of PIKfyve by apilimod significantly reduced entry of SARS-CoV S pseudovirions on 293/hACE2 cells in a dose dependent manner (Fig. 3b), whereas it had no effect on entry of VSV-G pseudovirions, which occurs in early endosomes. Similar inhibitory effects were observed when HeLa/hDPP4 cells and HeLa cells stably expressing mouse carcinoembryonic antigen related cell adhesion molecule 1a (mCEACAM1a) (HeLa/mCEACAM1a) were treated with apilimod and transduced with MERS-CoV and MHV S pseudovirions (Fig. 3b), respectively. Moreover, infection of live MHV on 17Cl.1 cells was also strongly inhibited by apilimod treatment (Fig. 3c). No significant cell toxicity was observed on apilimod at any concentration tested (Fig. 3c). We then determined whether apilimod could inhibit entry of SARS-CoV-2 S pseudovirions on 293/hACE2. As expected, apilimod treatment inhibited entry of SARS-CoV-2 S pseudovirions in a dose dependent manner (Fig. 3d). Similar effects were shown when 293/hACE2 cells were treated with YM201636, another PIKfyve inhibitor (Fig. 3e). These results suggested that PIKfyve might be a potential general drug target for viruses that enter cells through endocytosis. Two pore channel subtype 2 (TPC2) and TRPML1 in lysosome are two major downstream effectors of PI(3,5)P236. While blocking TPC2 activity by tetrandrine, an inhibitor for TPC237, decreased entry of SARS-CoV-2 S pseudovirions (Fig. 3f), treatment of cells with 130, a TRPML1 inhibitor, had no effect (Supplementary Fig. 1), indicating that TPC2, not TRPML1, is important for SARS-CoV-2 entry.","divisions":[{"label":"title","span":{"begin":0,"end":46}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T128","span":{"begin":126,"end":146},"obj":"Body_part"},{"id":"T129","span":{"begin":193,"end":207},"obj":"Body_part"},{"id":"T130","span":{"begin":211,"end":224},"obj":"Body_part"},{"id":"T131","span":{"begin":240,"end":260},"obj":"Body_part"},{"id":"T132","span":{"begin":337,"end":351},"obj":"Body_part"},{"id":"T133","span":{"begin":367,"end":372},"obj":"Body_part"},{"id":"T134","span":{"begin":538,"end":543},"obj":"Body_part"},{"id":"T135","span":{"begin":656,"end":671},"obj":"Body_part"},{"id":"T136","span":{"begin":730,"end":735},"obj":"Body_part"},{"id":"T137","span":{"begin":745,"end":750},"obj":"Body_part"},{"id":"T138","span":{"begin":808,"end":830},"obj":"Body_part"},{"id":"T139","span":{"begin":808,"end":812},"obj":"Body_part"},{"id":"T140","span":{"begin":1010,"end":1015},"obj":"Body_part"},{"id":"T141","span":{"begin":1092,"end":1096},"obj":"Body_part"},{"id":"T142","span":{"begin":1428,"end":1433},"obj":"Body_part"},{"id":"T143","span":{"begin":1600,"end":1605},"obj":"Body_part"},{"id":"T144","span":{"begin":1675,"end":1683},"obj":"Body_part"},{"id":"T145","span":{"begin":1875,"end":1880},"obj":"Body_part"}],"attributes":[{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma85436"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma67463"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma67467"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma85436"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma67463"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma67463"},{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma67214"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":1631,"end":1635},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0008915"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T132","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"T133","span":{"begin":500,"end":508},"obj":"Disease"},{"id":"T134","span":{"begin":978,"end":987},"obj":"Disease"},{"id":"T135","span":{"begin":1229,"end":1237},"obj":"Disease"},{"id":"T136","span":{"begin":1321,"end":1329},"obj":"Disease"},{"id":"T137","span":{"begin":1824,"end":1832},"obj":"Disease"},{"id":"T138","span":{"begin":2000,"end":2008},"obj":"Disease"}],"attributes":[{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T331","span":{"begin":172,"end":174},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T332","span":{"begin":331,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T333","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T334","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T335","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T336","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T337","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T338","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T339","span":{"begin":357,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T340","span":{"begin":367,"end":372},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T341","span":{"begin":401,"end":402},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T342","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T343","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T344","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T345","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T346","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T347","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T348","span":{"begin":528,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T349","span":{"begin":538,"end":543},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T350","span":{"begin":547,"end":548},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T351","span":{"begin":719,"end":723},"obj":"http://purl.obolibrary.org/obo/CLO_0003684"},{"id":"T352","span":{"begin":719,"end":723},"obj":"http://purl.obolibrary.org/obo/CLO_0050910"},{"id":"T353","span":{"begin":730,"end":735},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T354","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054283"},{"id":"T355","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054285"},{"id":"T356","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054286"},{"id":"T357","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054287"},{"id":"T358","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054288"},{"id":"T359","span":{"begin":740,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0054289"},{"id":"T360","span":{"begin":740,"end":744},"obj":"http://purl.obolibrary.org/obo/CLO_0003684"},{"id":"T361","span":{"begin":740,"end":744},"obj":"http://purl.obolibrary.org/obo/CLO_0050910"},{"id":"T362","span":{"begin":769,"end":774},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T363","span":{"begin":808,"end":812},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T364","span":{"begin":847,"end":851},"obj":"http://purl.obolibrary.org/obo/CLO_0003684"},{"id":"T365","span":{"begin":847,"end":851},"obj":"http://purl.obolibrary.org/obo/CLO_0050910"},{"id":"T366","span":{"begin":1008,"end":1015},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T367","span":{"begin":1092,"end":1096},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T368","span":{"begin":1152,"end":1158},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T369","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T370","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T371","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T372","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T373","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T374","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T375","span":{"begin":1259,"end":1262},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T376","span":{"begin":1351,"end":1352},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T377","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0001230"},{"id":"T378","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0037237"},{"id":"T379","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0050903"},{"id":"T380","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0054249"},{"id":"T381","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0054250"},{"id":"T382","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0054251"},{"id":"T383","span":{"begin":1418,"end":1421},"obj":"http://purl.obolibrary.org/obo/CLO_0054252"},{"id":"T384","span":{"begin":1428,"end":1433},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T385","span":{"begin":1545,"end":1546},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T386","span":{"begin":1581,"end":1588},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T387","span":{"begin":1600,"end":1605},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T388","span":{"begin":1675,"end":1683},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T389","span":{"begin":1755,"end":1763},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T390","span":{"begin":1875,"end":1880},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T391","span":{"begin":1891,"end":1892},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T331","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T340","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T341","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T342","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T343","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T345","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T346","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T347","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T348","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T353","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T354","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T355","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T356","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T357","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T358","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T359","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T382","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T383","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T384","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T385","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T386","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T387","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T388","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T389","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T390","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T391","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T122","span":{"begin":126,"end":146},"obj":"Chemical"},{"id":"T123","span":{"begin":165,"end":167},"obj":"Chemical"},{"id":"T127","span":{"begin":172,"end":174},"obj":"Chemical"},{"id":"T128","span":{"begin":240,"end":272},"obj":"Chemical"},{"id":"T129","span":{"begin":240,"end":260},"obj":"Chemical"},{"id":"T130","span":{"begin":263,"end":272},"obj":"Chemical"},{"id":"T134","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"T138","span":{"begin":331,"end":333},"obj":"Chemical"},{"id":"T139","span":{"begin":410,"end":419},"obj":"Chemical"},{"id":"T140","span":{"begin":792,"end":799},"obj":"Chemical"},{"id":"T141","span":{"begin":822,"end":830},"obj":"Chemical"},{"id":"T142","span":{"begin":1003,"end":1007},"obj":"Chemical"},{"id":"T143","span":{"begin":1478,"end":1487},"obj":"Chemical"},{"id":"T144","span":{"begin":1565,"end":1569},"obj":"Chemical"},{"id":"T145","span":{"begin":1722,"end":1724},"obj":"Chemical"},{"id":"T149","span":{"begin":1783,"end":1792},"obj":"Chemical"},{"id":"T150","span":{"begin":1900,"end":1909},"obj":"Chemical"}],"attributes":[{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A124","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A125","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A126","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_17283"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_16749"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A131","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A132","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A133","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A135","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A136","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A137","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A146","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A147","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A148","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":94,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T22","span":{"begin":808,"end":830},"obj":"http://purl.obolibrary.org/obo/GO_0098631"},{"id":"T23","span":{"begin":808,"end":821},"obj":"http://purl.obolibrary.org/obo/GO_0007155"},{"id":"T24","span":{"begin":1614,"end":1625},"obj":"http://purl.obolibrary.org/obo/GO_0006897"}],"attributes":[{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T114","span":{"begin":0,"end":46},"obj":"Sentence"},{"id":"T115","span":{"begin":47,"end":106},"obj":"Sentence"},{"id":"T116","span":{"begin":107,"end":239},"obj":"Sentence"},{"id":"T117","span":{"begin":240,"end":352},"obj":"Sentence"},{"id":"T118","span":{"begin":353,"end":434},"obj":"Sentence"},{"id":"T119","span":{"begin":435,"end":672},"obj":"Sentence"},{"id":"T120","span":{"begin":673,"end":967},"obj":"Sentence"},{"id":"T121","span":{"begin":968,"end":1076},"obj":"Sentence"},{"id":"T122","span":{"begin":1077,"end":1169},"obj":"Sentence"},{"id":"T123","span":{"begin":1170,"end":1269},"obj":"Sentence"},{"id":"T124","span":{"begin":1270,"end":1385},"obj":"Sentence"},{"id":"T125","span":{"begin":1386,"end":1498},"obj":"Sentence"},{"id":"T126","span":{"begin":1499,"end":1626},"obj":"Sentence"},{"id":"T127","span":{"begin":1627,"end":1734},"obj":"Sentence"},{"id":"T128","span":{"begin":1735,"end":2017},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T114","pred":"source","obj":"LitCovid-sentences"},{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"},{"subj":"T117","pred":"source","obj":"LitCovid-sentences"},{"subj":"T118","pred":"source","obj":"LitCovid-sentences"},{"subj":"T119","pred":"source","obj":"LitCovid-sentences"},{"subj":"T120","pred":"source","obj":"LitCovid-sentences"},{"subj":"T121","pred":"source","obj":"LitCovid-sentences"},{"subj":"T122","pred":"source","obj":"LitCovid-sentences"},{"subj":"T123","pred":"source","obj":"LitCovid-sentences"},{"subj":"T124","pred":"source","obj":"LitCovid-sentences"},{"subj":"T125","pred":"source","obj":"LitCovid-sentences"},{"subj":"T126","pred":"source","obj":"LitCovid-sentences"},{"subj":"T127","pred":"source","obj":"LitCovid-sentences"},{"subj":"T128","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32221306-19582903-73894024","span":{"begin":233,"end":235},"obj":"19582903"},{"id":"32221306-16954148-73894025","span":{"begin":236,"end":238},"obj":"16954148"},{"id":"32221306-28403145-73894026","span":{"begin":431,"end":433},"obj":"28403145"},{"id":"32221306-30424907-73894027","span":{"begin":1730,"end":1733},"obj":"30424907"},{"id":"32221306-25722412-73894028","span":{"begin":1800,"end":1803},"obj":"25722412"}],"attributes":[{"subj":"32221306-19582903-73894024","pred":"source","obj":"2_test"},{"subj":"32221306-16954148-73894025","pred":"source","obj":"2_test"},{"subj":"32221306-28403145-73894026","pred":"source","obj":"2_test"},{"subj":"32221306-30424907-73894027","pred":"source","obj":"2_test"},{"subj":"32221306-25722412-73894028","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"672","span":{"begin":12,"end":16},"obj":"Gene"},{"id":"673","span":{"begin":30,"end":40},"obj":"Species"},{"id":"715","span":{"begin":361,"end":366},"obj":"Gene"},{"id":"716","span":{"begin":532,"end":537},"obj":"Gene"},{"id":"717","span":{"begin":1263,"end":1268},"obj":"Gene"},{"id":"718","span":{"begin":1422,"end":1427},"obj":"Gene"},{"id":"719","span":{"begin":1655,"end":1659},"obj":"Gene"},{"id":"720","span":{"begin":1665,"end":1671},"obj":"Gene"},{"id":"721","span":{"begin":1750,"end":1754},"obj":"Gene"},{"id":"722","span":{"begin":1797,"end":1801},"obj":"Gene"},{"id":"723","span":{"begin":1893,"end":1899},"obj":"Gene"},{"id":"724","span":{"begin":1965,"end":1969},"obj":"Gene"},{"id":"725","span":{"begin":1975,"end":1981},"obj":"Gene"},{"id":"726","span":{"begin":724,"end":729},"obj":"Gene"},{"id":"727","span":{"begin":1835,"end":1836},"obj":"Gene"},{"id":"728","span":{"begin":1332,"end":1333},"obj":"Gene"},{"id":"729","span":{"begin":1240,"end":1241},"obj":"Gene"},{"id":"730","span":{"begin":1722,"end":1731},"obj":"Gene"},{"id":"731","span":{"begin":324,"end":333},"obj":"Gene"},{"id":"732","span":{"begin":165,"end":174},"obj":"Gene"},{"id":"733","span":{"begin":500,"end":508},"obj":"Species"},{"id":"734","span":{"begin":910,"end":918},"obj":"Species"},{"id":"735","span":{"begin":923,"end":928},"obj":"Species"},{"id":"736","span":{"begin":1229,"end":1239},"obj":"Species"},{"id":"737","span":{"begin":1321,"end":1331},"obj":"Species"},{"id":"738","span":{"begin":1824,"end":1834},"obj":"Species"},{"id":"739","span":{"begin":2000,"end":2010},"obj":"Species"},{"id":"740","span":{"begin":996,"end":999},"obj":"Species"},{"id":"741","span":{"begin":47,"end":64},"obj":"Chemical"},{"id":"742","span":{"begin":126,"end":163},"obj":"Chemical"},{"id":"743","span":{"begin":391,"end":399},"obj":"Chemical"},{"id":"744","span":{"begin":1047,"end":1055},"obj":"Chemical"},{"id":"745","span":{"begin":1122,"end":1130},"obj":"Chemical"},{"id":"746","span":{"begin":1283,"end":1291},"obj":"Chemical"},{"id":"747","span":{"begin":1452,"end":1460},"obj":"Chemical"},{"id":"748","span":{"begin":1767,"end":1778},"obj":"Chemical"},{"id":"749","span":{"begin":775,"end":791},"obj":"Disease"},{"id":"750","span":{"begin":978,"end":987},"obj":"Disease"},{"id":"751","span":{"begin":1097,"end":1105},"obj":"Disease"},{"id":"752","span":{"begin":353,"end":360},"obj":"CellLine"},{"id":"753","span":{"begin":719,"end":723},"obj":"CellLine"},{"id":"754","span":{"begin":740,"end":744},"obj":"CellLine"},{"id":"755","span":{"begin":847,"end":851},"obj":"CellLine"}],"attributes":[{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"Gene:219931"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"Tax:2697049"},{"id":"A715","pred":"tao:has_database_id","subj":"715","obj":"Gene:59272"},{"id":"A716","pred":"tao:has_database_id","subj":"716","obj":"Gene:59272"},{"id":"A717","pred":"tao:has_database_id","subj":"717","obj":"Gene:59272"},{"id":"A718","pred":"tao:has_database_id","subj":"718","obj":"Gene:59272"},{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"Gene:219931"},{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Gene:57192"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"Gene:219931"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"Gene:219931"},{"id":"A723","pred":"tao:has_database_id","subj":"723","obj":"Gene:57192"},{"id":"A724","pred":"tao:has_database_id","subj":"724","obj":"Gene:219931"},{"id":"A725","pred":"tao:has_database_id","subj":"725","obj":"Gene:57192"},{"id":"A726","pred":"tao:has_database_id","subj":"726","obj":"Gene:1803"},{"id":"A727","pred":"tao:has_database_id","subj":"727","obj":"Gene:43740568"},{"id":"A728","pred":"tao:has_database_id","subj":"728","obj":"Gene:43740568"},{"id":"A729","pred":"tao:has_database_id","subj":"729","obj":"Gene:43740568"},{"id":"A730","pred":"tao:has_database_id","subj":"730","obj":"Gene:5266"},{"id":"A731","pred":"tao:has_database_id","subj":"731","obj":"Gene:5266"},{"id":"A732","pred":"tao:has_database_id","subj":"732","obj":"Gene:5266"},{"id":"A733","pred":"tao:has_database_id","subj":"733","obj":"Tax:694009"},{"id":"A734","pred":"tao:has_database_id","subj":"734","obj":"Tax:1335626"},{"id":"A735","pred":"tao:has_database_id","subj":"735","obj":"Tax:11145"},{"id":"A736","pred":"tao:has_database_id","subj":"736","obj":"Tax:2697049"},{"id":"A737","pred":"tao:has_database_id","subj":"737","obj":"Tax:2697049"},{"id":"A738","pred":"tao:has_database_id","subj":"738","obj":"Tax:2697049"},{"id":"A739","pred":"tao:has_database_id","subj":"739","obj":"Tax:2697049"},{"id":"A740","pred":"tao:has_database_id","subj":"740","obj":"Tax:11138"},{"id":"A741","pred":"tao:has_database_id","subj":"741","obj":"MESH:D010716"},{"id":"A742","pred":"tao:has_database_id","subj":"742","obj":"MESH:C106336"},{"id":"A743","pred":"tao:has_database_id","subj":"743","obj":"MESH:C504227"},{"id":"A744","pred":"tao:has_database_id","subj":"744","obj":"MESH:C504227"},{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"MESH:C504227"},{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"MESH:C504227"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"MESH:C540576"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"MESH:C009438"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"MESH:D007239"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"MESH:D064420"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"CVCL:0045"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"CVCL:0030"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"CVCL:0030"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"CVCL:0030"},{"subj":"672","pred":"source","obj":"LitCovid-PubTator"},{"subj":"673","pred":"source","obj":"LitCovid-PubTator"},{"subj":"715","pred":"source","obj":"LitCovid-PubTator"},{"subj":"716","pred":"source","obj":"LitCovid-PubTator"},{"subj":"717","pred":"source","obj":"LitCovid-PubTator"},{"subj":"718","pred":"source","obj":"LitCovid-PubTator"},{"subj":"719","pred":"source","obj":"LitCovid-PubTator"},{"subj":"720","pred":"source","obj":"LitCovid-PubTator"},{"subj":"721","pred":"source","obj":"LitCovid-PubTator"},{"subj":"722","pred":"source","obj":"LitCovid-PubTator"},{"subj":"723","pred":"source","obj":"LitCovid-PubTator"},{"subj":"724","pred":"source","obj":"LitCovid-PubTator"},{"subj":"725","pred":"source","obj":"LitCovid-PubTator"},{"subj":"726","pred":"source","obj":"LitCovid-PubTator"},{"subj":"727","pred":"source","obj":"LitCovid-PubTator"},{"subj":"728","pred":"source","obj":"LitCovid-PubTator"},{"subj":"729","pred":"source","obj":"LitCovid-PubTator"},{"subj":"730","pred":"source","obj":"LitCovid-PubTator"},{"subj":"731","pred":"source","obj":"LitCovid-PubTator"},{"subj":"732","pred":"source","obj":"LitCovid-PubTator"},{"subj":"733","pred":"source","obj":"LitCovid-PubTator"},{"subj":"734","pred":"source","obj":"LitCovid-PubTator"},{"subj":"735","pred":"source","obj":"LitCovid-PubTator"},{"subj":"736","pred":"source","obj":"LitCovid-PubTator"},{"subj":"737","pred":"source","obj":"LitCovid-PubTator"},{"subj":"738","pred":"source","obj":"LitCovid-PubTator"},{"subj":"739","pred":"source","obj":"LitCovid-PubTator"},{"subj":"740","pred":"source","obj":"LitCovid-PubTator"},{"subj":"741","pred":"source","obj":"LitCovid-PubTator"},{"subj":"742","pred":"source","obj":"LitCovid-PubTator"},{"subj":"743","pred":"source","obj":"LitCovid-PubTator"},{"subj":"744","pred":"source","obj":"LitCovid-PubTator"},{"subj":"745","pred":"source","obj":"LitCovid-PubTator"},{"subj":"746","pred":"source","obj":"LitCovid-PubTator"},{"subj":"747","pred":"source","obj":"LitCovid-PubTator"},{"subj":"748","pred":"source","obj":"LitCovid-PubTator"},{"subj":"749","pred":"source","obj":"LitCovid-PubTator"},{"subj":"750","pred":"source","obj":"LitCovid-PubTator"},{"subj":"751","pred":"source","obj":"LitCovid-PubTator"},{"subj":"752","pred":"source","obj":"LitCovid-PubTator"},{"subj":"753","pred":"source","obj":"LitCovid-PubTator"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93d9ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#ece593"},{"id":"LitCovid-PD-MONDO","color":"#cb93ec"},{"id":"LitCovid-PD-CLO","color":"#93ecb1"},{"id":"LitCovid-PD-CHEBI","color":"#ec9793"},{"id":"LitCovid-PD-GO-BP","color":"#93a9ec"},{"id":"LitCovid-sentences","color":"#c3ec93"},{"id":"2_test","color":"#ec93dd"},{"id":"LitCovid-PubTator","color":"#93ece1"}]}]}}