PMC:7095246 / 18848-21433 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7095246","sourcedb":"PMC","sourceid":"7095246","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7095246","text":"In a recent study done by Michael et al, they introduced a method to score the severity of inflammation on CT images based on summing up degree of acute lung inflammation lesions involvement of each lobe (including ground-glass opacity or consolidation or other fuzzy interstitial opacities) [9]. We used the same method to quantify pulmonary inflammation and correlate to the clinical classifications. There was significant difference in scores between common type and severe-critical type (p \u003c 0.001). However, there was also a score overlap between the two groups, which showed that 8 cases in the common type had a higher score, and 5 cases in the severe-critical type had a lower score. Among 8 cases of common type, 7 cases had fibrotic lesions which indicated that the lesions began to be repaired, and all of the 8 patients were less than 70 years old (range 36–65, average 52.5 years), none of them had pulmonary complications. The specific situation of 5 patients in a severe-critical type which had a lower score was as follows: 3 of the 5 patients were over 70 years old; among them, 1 patient was a female smoker with diabetes, aged 80 years old, with moderate emphysema and a small amount of pleural effusion; 1 patient was a 70-year-old female, with emphysema and a small amount of pleural effusion as well; the other one was 75-year-old female with high blood pressure; the forth case was a 44-year-old male without any underlying disease; however, CT images showed only progressive lesions such as ground-glass opacification and consolidation without any fibrotic lesions (Fig. 5). The last case was a 58-year-old female without any underlying disease; further analysis was needed to find out the cause of clinical severity. Overall, we believe that many factors, such as advanced age, underlying diseases, and pleural effusions, would relate to the clinical severity, which call for a comprehensive evaluation.\nFig. 5 A 44-year-old male was admitted to the hospital 1 day after fever and cough with a body temperature of 39 °C. The leukocytes were normal and lymphocytes were decreased. He was living in Zhuhai and traveled to Macao 12 days before the onset of the disease and stayed in Macao for 1 week. He was healthy and nonsmoker. Chest CT (images a–c) on the 4th day after admission demonstrated bilateral peripheral ground-glass opacities without consolidation. TSS was 9. The clinical type was severe-critical type. Follow-up CT (images d, e) on the 22nd day after onset showed bilateral fibrotic changes with traction bronchiectasis and ground-grass 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