PMC:7094172 / 553-954 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T17","span":{"begin":1,"end":9},"obj":"SP_9"},{"id":"T16","span":{"begin":92,"end":96},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T15","span":{"begin":204,"end":222},"obj":"CHEBI:41237;CHEBI:41237"},{"id":"T14","span":{"begin":232,"end":241},"obj":"PG_4"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":234,"end":241},"obj":"Body_part"},{"id":"T8","span":{"begin":308,"end":315},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":12,"end":15},"obj":"Disease"},{"id":"T3","span":{"begin":304,"end":307},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A4","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":39,"end":40},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":63,"end":69},"obj":"http://purl.obolibrary.org/obo/UBERON_0002553"},{"id":"T7","span":{"begin":226,"end":227},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":328,"end":338},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":92,"end":96},"obj":"Chemical"},{"id":"T8","span":{"begin":234,"end":241},"obj":"Chemical"},{"id":"T9","span":{"begin":242,"end":245},"obj":"Chemical"},{"id":"T11","span":{"begin":258,"end":268},"obj":"Chemical"},{"id":"T12","span":{"begin":288,"end":297},"obj":"Chemical"},{"id":"T13","span":{"begin":308,"end":315},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A10","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_77966"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":18,"end":107},"obj":"Sentence"},{"id":"T7","span":{"begin":108,"end":339},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}

{"project":"LitCovid-PubTator","denotations":[{"id":"9","span":{"begin":1,"end":9},"obj":"Species"},{"id":"10","span":{"begin":204,"end":222},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"tao:has_database_id","subj":"9","obj":"Tax:1335626"},{"id":"A10","pred":"tao:has_database_id","subj":"10","obj":"MESH:C006736"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"(MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed"}