PMC:7094172 / 38658-39336 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T175","span":{"begin":167,"end":174},"obj":"Body_part"},{"id":"T176","span":{"begin":190,"end":193},"obj":"Body_part"}],"attributes":[{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T124","span":{"begin":35,"end":38},"obj":"Disease"},{"id":"T126","span":{"begin":87,"end":90},"obj":"Disease"},{"id":"T128","span":{"begin":371,"end":380},"obj":"Disease"}],"attributes":[{"id":"A124","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A125","pred":"mondo_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A127","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T288","span":{"begin":47,"end":49},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T289","span":{"begin":121,"end":123},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T290","span":{"begin":121,"end":123},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T291","span":{"begin":337,"end":345},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T292","span":{"begin":365,"end":370},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T293","span":{"begin":381,"end":386},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T294","span":{"begin":396,"end":398},"obj":"http://purl.obolibrary.org/obo/CLO_0008933"},{"id":"T295","span":{"begin":467,"end":469},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T296","span":{"begin":587,"end":589},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T297","span":{"begin":587,"end":589},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T362","span":{"begin":121,"end":123},"obj":"Chemical"},{"id":"T363","span":{"begin":167,"end":174},"obj":"Chemical"},{"id":"T364","span":{"begin":236,"end":238},"obj":"Chemical"},{"id":"T365","span":{"begin":283,"end":292},"obj":"Chemical"},{"id":"T366","span":{"begin":322,"end":324},"obj":"Chemical"},{"id":"T367","span":{"begin":327,"end":336},"obj":"Chemical"},{"id":"T368","span":{"begin":396,"end":398},"obj":"Chemical"},{"id":"T369","span":{"begin":587,"end":589},"obj":"Chemical"},{"id":"T370","span":{"begin":642,"end":644},"obj":"Chemical"}],"attributes":[{"id":"A362","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A363","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A364","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A365","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A366","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_29401"},{"id":"A367","pred":"chebi_id","subj":"T367","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A368","pred":"chebi_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/CHEBI_29386"},{"id":"A369","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A370","pred":"chebi_id","subj":"T370","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T29","span":{"begin":167,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0050821"},{"id":"T30","span":{"begin":167,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0045185"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":371,"end":380},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}

{"project":"LitCovid-PubTator","denotations":[{"id":"631","span":{"begin":24,"end":32},"obj":"Species"},{"id":"632","span":{"begin":76,"end":84},"obj":"Species"},{"id":"633","span":{"begin":156,"end":164},"obj":"Species"},{"id":"634","span":{"begin":365,"end":386},"obj":"Species"},{"id":"635","span":{"begin":360,"end":363},"obj":"Species"}],"attributes":[{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"Tax:1335626"},{"id":"A632","pred":"tao:has_database_id","subj":"632","obj":"Tax:1335626"},{"id":"A633","pred":"tao:has_database_id","subj":"633","obj":"Tax:1335626"},{"id":"A634","pred":"tao:has_database_id","subj":"634","obj":"Tax:11138"},{"id":"A635","pred":"tao:has_database_id","subj":"635","obj":"Tax:11138"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Dimeric conformation of MERS-CoV N-NTD (Figure S1); LibDock pose of dimeric MERS-CoV N-NTD with potent compounds (Figure S2); P3-induced aggregation of the MERS-CoV N protein sequesters the RNA-binding region on the N-CTD dimer (Figure S3); potential target sites for broad-spectrum antiviral compound development (Figure S4); antiviral activity of P3 against MHV (mouse hepatitis virus) (Figure S5); crystallographic data collection and refinement statistics (Table S1); pW43 docking pose with chemical structures, docking scores, and biochemical properties of 17 potential hits (Table S2); primers used for mutagenesis in this study (Table S3); molecular formula strings (PDF)"}