PMC:7094172 / 31718-32341 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T523","span":{"begin":14,"end":23},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T522","span":{"begin":60,"end":64},"obj":"SP_9"},{"id":"T521","span":{"begin":92,"end":100},"obj":"SP_9"},{"id":"T520","span":{"begin":160,"end":164},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T519","span":{"begin":220,"end":224},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T518","span":{"begin":299,"end":308},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T517","span":{"begin":323,"end":332},"obj":"PG_4"},{"id":"T516","span":{"begin":338,"end":347},"obj":"PG_4"},{"id":"T515","span":{"begin":405,"end":413},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T147","span":{"begin":325,"end":332},"obj":"Body_part"},{"id":"T148","span":{"begin":340,"end":347},"obj":"Body_part"}],"attributes":[{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T113","span":{"begin":103,"end":106},"obj":"Disease"}],"attributes":[{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A114","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T235","span":{"begin":73,"end":74},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T236","span":{"begin":201,"end":209},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T237","span":{"begin":201,"end":209},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T238","span":{"begin":382,"end":383},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T239","span":{"begin":444,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T240","span":{"begin":620,"end":622},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T241","span":{"begin":620,"end":622},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T297","span":{"begin":48,"end":51},"obj":"Chemical"},{"id":"T299","span":{"begin":119,"end":122},"obj":"Chemical"},{"id":"T300","span":{"begin":160,"end":164},"obj":"Chemical"},{"id":"T301","span":{"begin":220,"end":224},"obj":"Chemical"},{"id":"T302","span":{"begin":325,"end":332},"obj":"Chemical"},{"id":"T303","span":{"begin":340,"end":347},"obj":"Chemical"},{"id":"T304","span":{"begin":509,"end":516},"obj":"Chemical"},{"id":"T305","span":{"begin":620,"end":622},"obj":"Chemical"}],"attributes":[{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A298","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_34780"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A302","pred":"chebi_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A303","pred":"chebi_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A305","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T244","span":{"begin":0,"end":175},"obj":"Sentence"},{"id":"T245","span":{"begin":176,"end":333},"obj":"Sentence"},{"id":"T246","span":{"begin":334,"end":399},"obj":"Sentence"},{"id":"T247","span":{"begin":400,"end":468},"obj":"Sentence"},{"id":"T248","span":{"begin":469,"end":623},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"504","span":{"begin":92,"end":100},"obj":"Species"},{"id":"505","span":{"begin":102,"end":106},"obj":"Chemical"},{"id":"506","span":{"begin":551,"end":559},"obj":"Chemical"},{"id":"507","span":{"begin":60,"end":71},"obj":"Disease"}],"attributes":[{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"Tax:1335626"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"MESH:D010984"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}

{"project":"2_test","denotations":[{"id":"32105468-19244385-61929528","span":{"begin":560,"end":562},"obj":"19244385"}],"text":"To screen for compounds that induce hydrophobic PPI between MERS N-NTDs, a model of dimeric MERS-CoV N-NTD without the H37 and M38 residues was used in virtual drug screening. The Sigma-Aldrich, Acros Organics, and ZINC drug databases were screened with LIBDOCK molecular docking software to obtain compounds acting on the N protein. The N protein binding pocket was represented by a set of spheres. Each compound in the database was docked in a pocket comprising W43. The hydrophobic complementarity between ligands and receptors was calculated with PLATINUM.31 Compounds with higher docking scores are listed in Table S2."}