PMC:7094172 / 27565-28114 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T394","span":{"begin":105,"end":116},"obj":"GO:0051259"},{"id":"T393","span":{"begin":128,"end":136},"obj":"SP_9"},{"id":"T392","span":{"begin":137,"end":146},"obj":"PG_4"},{"id":"T391","span":{"begin":232,"end":240},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T390","span":{"begin":443,"end":447},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T389","span":{"begin":513,"end":522},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T132","span":{"begin":85,"end":93},"obj":"Body_part"},{"id":"T133","span":{"begin":139,"end":146},"obj":"Body_part"}],"attributes":[{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T206","span":{"begin":421,"end":427},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T231","span":{"begin":85,"end":93},"obj":"Chemical"},{"id":"T232","span":{"begin":139,"end":146},"obj":"Chemical"},{"id":"T233","span":{"begin":232,"end":240},"obj":"Chemical"},{"id":"T234","span":{"begin":443,"end":447},"obj":"Chemical"},{"id":"T235","span":{"begin":508,"end":522},"obj":"Chemical"}],"attributes":[{"id":"A231","pred":"chebi_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A232","pred":"chebi_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A233","pred":"chebi_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A234","pred":"chebi_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_33585"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}

{"project":"LitCovid-sentences","denotations":[{"id":"T210","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T211","span":{"begin":118,"end":268},"obj":"Sentence"},{"id":"T212","span":{"begin":269,"end":381},"obj":"Sentence"},{"id":"T213","span":{"begin":382,"end":549},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}

{"project":"LitCovid-PubTator","denotations":[{"id":"437","span":{"begin":128,"end":136},"obj":"Species"}],"attributes":[{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Tax:1335626"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To summarize, we demonstrated that non-native interaction interfaces might form when proteins abnormally oligomerize. Using the MERS-CoV N protein as an example, we showed that non-native interfaces might serve as targets for small-molecule, structure-based screening. We also proposed several stratagems to rationally identify potential non-native interface targets for screening. We believe that we have discovered and tested an alternative drug discovery paradigm that could help expand the repertoire of lead compounds against various pathogens."}