PMC:7094172 / 27238-27564 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T395","span":{"begin":289,"end":298},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T204","span":{"begin":129,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0007874"},{"id":"T205","span":{"begin":132,"end":134},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T228","span":{"begin":101,"end":109},"obj":"Chemical"},{"id":"T229","span":{"begin":110,"end":119},"obj":"Chemical"},{"id":"T230","span":{"begin":129,"end":131},"obj":"Chemical"}],"attributes":[{"id":"A228","pred":"chebi_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A229","pred":"chebi_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/CHEBI_29237"},{"id":"A230","pred":"chebi_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/CHEBI_73613"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":120,"end":128},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"LitCovid-sentences","denotations":[{"id":"T209","span":{"begin":0,"end":326},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"LitCovid-PubTator","denotations":[{"id":"432","span":{"begin":101,"end":109},"obj":"Chemical"},{"id":"433","span":{"begin":110,"end":119},"obj":"Chemical"}],"attributes":[{"id":"A432","pred":"tao:has_database_id","subj":"432","obj":"MESH:D006859"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:D003903"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}

{"project":"2_test","denotations":[{"id":"32105468-16503614-61929523","span":{"begin":132,"end":134},"obj":"16503614"}],"text":"Another approach is to identify weakly interacting sites through NMR chemical shift perturbation and hydrogen-deuterium exchange MS.45 Once these potential non-native interaction interfaces are identified, standard screening and then functional characterization may be conducted for small compounds that bind to the interface."}