PMC:7094172 / 1612-1904 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7094172","sourcedb":"PMC","sourceid":"7094172","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7094172","text":"process alters the oligomerization equilibrium of the protein and enables small molecules to modulate its physiological function.4−7 The anticancer drug paclitaxel, for example, allosterically enhances microtubule structure assembly by binding to β-tubulin.8,9 On the other hand, rapamycin, a","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T120","span":{"begin":19,"end":34},"obj":"GO:0051260"},{"id":"T119","span":{"begin":80,"end":89},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T118","span":{"begin":93,"end":101},"obj":"GO:0065007"},{"id":"T117","span":{"begin":137,"end":147},"obj":"CHEBI:35718;CHEBI:35718"},{"id":"T116","span":{"begin":148,"end":152},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T115","span":{"begin":153,"end":163},"obj":"CHEBI:45863;CHEBI:45863"},{"id":"T114","span":{"begin":202,"end":213},"obj":"GO:0005874;GO:0090307"},{"id":"T113","span":{"begin":214,"end":232},"obj":"GO:0090307"},{"id":"T112","span":{"begin":249,"end":256},"obj":"PR:000028799"},{"id":"T111","span":{"begin":280,"end":289},"obj":"CHEBI:33893;CHEBI:33893"}],"attributes":[{"subj":"T120","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T119","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T118","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T117","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T116","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T115","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T114","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T113","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T112","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T111","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T14","span":{"begin":54,"end":61},"obj":"Body_part"},{"id":"T15","span":{"begin":202,"end":213},"obj":"Body_part"},{"id":"T16","span":{"begin":249,"end":256},"obj":"Body_part"},{"id":"T17","span":{"begin":274,"end":278},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma63849"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67116"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma9712"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":274,"end":278},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid_AGAC","denotations":[{"id":"p35652s4","span":{"begin":19,"end":46},"obj":"MPA"},{"id":"p35652s8","span":{"begin":54,"end":61},"obj":"Protein"},{"id":"p35652s29","span":{"begin":193,"end":201},"obj":"PosReg"},{"id":"p35652s30","span":{"begin":202,"end":232},"obj":"MPA"}],"attributes":[{"subj":"p35652s4","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p35652s8","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p35652s29","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p35652s30","pred":"source","obj":"LitCovid_AGAC"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22","span":{"begin":54,"end":61},"obj":"Chemical"},{"id":"T23","span":{"begin":80,"end":89},"obj":"Chemical"},{"id":"T24","span":{"begin":148,"end":152},"obj":"Chemical"},{"id":"T25","span":{"begin":153,"end":163},"obj":"Chemical"},{"id":"T26","span":{"begin":280,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_45863"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_9168"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"25","span":{"begin":153,"end":163},"obj":"Chemical"},{"id":"26","span":{"begin":280,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D017239"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D020123"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32105468-30957264-61929490","span":{"begin":129,"end":130},"obj":"30957264"},{"id":"32105468-30913483-61929491","span":{"begin":131,"end":132},"obj":"30913483"}],"attributes":[{"subj":"32105468-30957264-61929490","pred":"source","obj":"2_test"},{"subj":"32105468-30913483-61929491","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#e3ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#da93ec"},{"id":"LitCovid-PD-UBERON","color":"#93ecc0"},{"id":"LitCovid_AGAC","color":"#eca693"},{"id":"LitCovid-PD-CHEBI","color":"#9399ec"},{"id":"LitCovid-PubTator","color":"#b3ec93"},{"id":"2_test","color":"#ec93cd"}]}]}}